Homeostatic scaling of active zone scaffolds maintains global synaptic strength

The Journal of Cell Biology, Год журнала: 2019, Номер 218(5), С. 1706 - 1724

Опубликована: Март 26, 2019

Synaptic terminals grow and retract throughout life, yet synaptic strength is maintained within stable physiological ranges. To study this process, we investigated Drosophila endophilin (endo) mutants. Although active zone (AZ) number doubled in endo mutants, a compensatory reduction their size homeostatically adjusts global neurotransmitter output to maintain strength. We find an inverse adaptation rab3 Additional analyses using confocal, STED, electron microscopy reveal stoichiometric tuning of AZ scaffolds nanoarchitecture. Axonal transport cargo via the lysosomal kinesin adapter Arl8 regulates abundance modulate sustain homeostatic potentiation neurotransmission. Finally, that scaling can interface with two independent homeostats, depression potentiation, remodel structure function, demonstrating robust balancing separate adaptations. Thus, AZs are pliable substrates elastic modular nanostructures be dynamically sculpted stabilize tune both local

Язык: Английский

---

The paraventricular nucleus of the thalamus: an integrative node underlying homeostatic behavior

Trends in Neurosciences, Год журнала: 2021, Номер 44(7), С. 538 - 549

Опубликована: Март 25, 2021

Язык: Английский

---

A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics

Trends in Neurosciences, Год журнала: 2020, Номер 44(4), С. 260 - 275

Опубликована: Дек. 21, 2020

Язык: Английский

---

A transcriptional rheostat couples past activity to future sensory responses

Cell, Год журнала: 2021, Номер 184(26), С. 6326 - 6343.e32

Опубликована: Дек. 1, 2021

Animals traversing different environments encounter both stable background stimuli and novel cues, which are thought to be detected by primary sensory neurons then distinguished downstream brain circuits. Here, we show that each of the ∼1,000 olfactory neuron (OSN) subtypes in mouse harbors a distinct transcriptome whose content is precisely determined interactions between its odorant receptor environment. This transcriptional variation systematically organized support adaptation: expression levels more than 70 genes relevant transforming odors into spikes continuously vary across OSN subtypes, dynamically adjust new over hours, accurately predict acute OSN-specific odor responses. The periphery therefore separates salient signals from predictable via rheostat moment-to-moment state reflects past constrains future; these findings suggest general model structured within cell type individual experience.

Язык: Английский

---

Linking activity dyshomeostasis and sleep disturbances in Alzheimer disease

Nature reviews. Neuroscience, Год журнала: 2024, Номер 25(4), С. 272 - 284

Опубликована: Фев. 19, 2024

Язык: Английский

---