Neural plasticity and behavior – sixty years of conceptual advances

Journal of Neurochemistry, Год журнала: 2016, Номер 139(S2), С. 179 - 199

Опубликована: Фев. 15, 2016

This brief review summarizes 60 years of conceptual advances that have demonstrated a role for active changes in neuronal connectivity as controller behavior and behavioral change. Seminal studies the first phase six-decade span this firmly established cellular basis - concept we take granted now, but which was an open question at time. Hebbian plasticity, including long-term potentiation depression, then discovered being important local circuit refinement context memory formation change stabilization mammalian central nervous system. Direct demonstration plasticity function vivo, example, hippocampal neurons forming place cell firing patterns, extended concept. However, additional neurophysiologic computational development additionally relies on non-Hebbian, homoeostatic, forms such synaptic scaling control membrane intrinsic properties. Activity-dependent neurodevelopment found to be associated with cell-wide adjustments post-synaptic receptor density, occur conjunction pruning. Pioneering critical roles transmembrane signal transduction, NMDA regulation, regulation neural biophysical properties, back-propagating action potential time-dependent coincidence detection behavior-modifying circuits. Concerning molecular mechanisms underlying these processes, gene transcription serve bridge between experience change, closing 'nature versus nurture' divide. Both DNA (de)methylation chromatin structure been validated crucial regulators during learning. The discovery protein synthesis dependence acquisition influential neurochemistry modification. Higher order cognitive functions decision making spatial language learning were also hinge mechanisms. disruption processes intellectual disabilities, disorders, drug addiction has recently clarified based modern genetic techniques, human. area seen tremendous over last six decades, many those specifically domain. provides overview progress neuroplasticity life-span Journal Neurochemistry. To organize broad literature base, collates into fifteen categories identified 'conceptual advances', viewed by author. areas are delineated figure above. article is part 60th Anniversary special issue.

Язык: Английский

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Applications of CRISPR–Cas systems in neuroscience

Nature reviews. Neuroscience, Год журнала: 2015, Номер 17(1), С. 36 - 44

Опубликована: Дек. 10, 2015

Язык: Английский

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Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(8), С. 471 - 484

Опубликована: Июнь 22, 2017

Язык: Английский

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Neuronal activity modifies the chromatin accessibility landscape in the adult brain

Nature Neuroscience, Год журнала: 2017, Номер 20(3), С. 476 - 483

Опубликована: Фев. 6, 2017

Язык: Английский

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Epigenetic Effects of Cannabis Exposure

Biological Psychiatry, Год журнала: 2015, Номер 79(7), С. 586 - 594

Опубликована: Ноя. 4, 2015

Язык: Английский

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Epigenetic mechanisms in neurological and neurodegenerative diseases

Frontiers in Cellular Neuroscience, Год журнала: 2015, Номер 9

Опубликована: Фев. 27, 2015

The role of epigenetic mechanisms in the function and homeostasis central nervous system (CNS) its regulation diseases is one most interesting processes contemporary neuroscience. In last decade, a growing body literature suggests that long-term changes gene transcription associated with CNS´s neurological disorders are mediated via modulation chromatin structure. "Epigenetics", introduced for first time by Waddington early 1940s, has been traditionally referred to variety allow heritable expression even absence DNA mutation. However, new definitions acknowledge many these used perpetuate traits dividing cells neurons control functions dependent on expression. Indeed, recent years have shown their importance maintenance healthy CNS. Moreover, environmental inputs effects CNS diseases, such as nutrition, can modulate concentration metabolites acetyl-coenzyme A (acetyl-coA), nicotinamide adenine dinucleotide (NAD+) beta hydroxybutyrate (β-HB), regulates some modifications, linking precise way environment This manuscript will portray what currently understood about participation disorders. We discuss how machinery controls modifications plays an important involved neurogenesis cell growth. we producing metabolic physiological alterations could exert beneficial diseases. Finally, highlight possible future directions field epigenetics

Язык: Английский

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The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders

Genes, Год журнала: 2017, Номер 8(3), С. 104 - 104

Опубликована: Март 18, 2017

Prenatal adverse environments, such as maternal stress, toxicological exposures, and viral infections, can disrupt normal brain development contribute to neurodevelopmental disorders, including schizophrenia, depression, autism. Increasing evidence shows that these short- long-term effects of prenatal exposures on structure function are mediated by epigenetic mechanisms. Animal studies demonstrate exposure toxins, mimetics, drugs induces lasting changes in the brain, genes encoding glucocorticoid receptor (Nr3c1) brain-derived neurotrophic factor (Bdnf). These have been linked gene expression, stress reactivity, behavior, often times, shown be dependent gestational window exposure, sex, level. Although from human is more limited, environmental risks humans associated with peripheral tissues, future required understand whether we use biomarkers predict neurobehavioral outcomes. An extensive research effort combining well-designed animal studies, comprehensive epigenomic analyses tissues over time, will necessary improve our understanding basis disorders.

Язык: Английский

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Epigenetic regulation and chromatin remodeling in learning and memory

Experimental & Molecular Medicine, Год журнала: 2017, Номер 49(1), С. e281 - e281

Опубликована: Янв. 13, 2017

Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in field neuroscience. Memory are tightly controlled complex processes. Among various processes occurring at different levels, gene expression regulation is especially crucial for proper processing, as some genes need to be activated while must suppressed. Epigenetic genome involves such DNA methylation histone post-translational modifications. These edit genomic properties or interactions between cores. They then induce structural changes chromatin lead transcriptional genes. Recent studies have focused on concept remodeling, which consists 3D relation regulation, an important process learning memory. In this review, we will introduce three epigenetic involved regulation: methylation, acetylation. We also discuss general long-term storage relate control remodeling. Finally, how can contribute pathologies neurological disorders cause memory-related symptoms. help memory, brain disorders. review article, Somi Kim Bong-Kiun Kaang from Seoul National University, South Korea, (the addition chemical tags proteins that act spools around winds) influence affect storage. The researchers describe main - acetylation all drive repress promotion suppression. collectively physical structure DNA-protein complexes ways consolidation. A better understanding could new therapies conditions Huntington's disease.

Язык: Английский

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The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation

Neuropsychopharmacology, Год журнала: 2017, Номер 42(7), С. 1502 - 1510

Опубликована: Фев. 16, 2017

Язык: Английский

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Histone H3 lysine K4 methylation and its role in learning and memory

Epigenetics & Chromatin, Год журнала: 2019, Номер 12(1)

Опубликована: Янв. 7, 2019

Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying the underlying genomic sequence. A number of studies animal models have shown that dysregulation various components epigenetic machinery causes cognitive deficits at behavioral level, suggesting proper control is necessary for fundamental processes learning and memory. Histone H3 lysine K4 (H3K4) comprises one component control, global levels this mark are increased hippocampus during memory formation. Modifiers H3K4 needed formation, through studies, many same modifiers mutated human diseases. Indeed, all known methyltransferases four six demethylases been associated with impaired cognition a neurologic or psychiatric disorder. Cognitive impairment patients often manifests intellectual disability, consistent role As modification quintessentially, but not exclusively, transcriptional activity, provides unique insights into regulatory complexity writing, reading, erasing marks within an activated neuron. The following review will discuss connect it to events required developed nervous system. This include initial discussion most recent advances developing methodology analyze methylation, namely mass spectrometry deep sequencing, well how these methods can be applied more deeply understand biology brain. We then introduce core enzymatic mediating addition removal resulting signatures throughout neuronal genome. next foray brain, discussing changes formation retrieval, correlates methyltransferase deficiency region. Finally, we diseases connected each modulator summarize drugs target them.

Язык: Английский

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