The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Pharmacological Reviews, Год журнала: 2016, Номер 68(3), С. 816 - 871

Опубликована: Июнь 30, 2016

The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical limbic structures to mediate goal-directed behaviors. Chronic exposure several classes drugs abuse disrupts plasticity in this region, allowing drug-associated cues engender pathologic motivation for drug seeking. A number alterations glutamatergic transmission occur within after withdrawal chronic exposure. These drug-induced neuroadaptations serve as molecular basis relapse vulnerability. In review, we focus on role that glutamate signal transduction plays addiction-related First, explore accumbens, including cell types neuronal populations present well afferent efferent connections. Next discuss rodent models addiction assess viability these testing candidate pharmacotherapies prevention relapse. Then provide review literature describing how synaptic altered also pharmacological manipulation systems can inhibit seeking laboratory setting. Finally, examine results clinical trials which designed manipulate have been effective treating human patients. Further elucidation alter will be necessary development new therapeutics treatment across all addictive substances.

Язык: Английский

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Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

Neuropsychopharmacology, Год журнала: 2015, Номер 41(1), С. 335 - 356

Опубликована: Май 15, 2015

Язык: Английский

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Prefrontal cortex output circuits guide reward seeking through divergent cue encoding

Nature, Год журнала: 2017, Номер 543(7643), С. 103 - 107

Опубликована: Фев. 21, 2017

Язык: Английский

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The ins and outs of the striatum: Role in drug addiction

Neuroscience, Год журнала: 2015, Номер 301, С. 529 - 541

Опубликована: Июнь 24, 2015

Язык: Английский

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Synaptic mechanisms underlying persistent cocaine craving

Nature reviews. Neuroscience, Год журнала: 2016, Номер 17(6), С. 351 - 365

Опубликована: Май 6, 2016

Язык: Английский

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Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry

Neuron, Год журнала: 2015, Номер 88(2), С. 247 - 263

Опубликована: Окт. 1, 2015

Язык: Английский

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Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Май 6, 2020

Abstract Dysregulated prefrontal control over amygdala is engaged in the pathogenesis of psychiatric diseases including depression and anxiety disorders. Here we show that, a rodent model induced by chronic restraint stress (CRS), dysregulation occurs basolateral projection neurons receiving mono-directional inputs from dorsomedial cortex (dmPFC→BLA PNs) rather than those reciprocally connected with dmPFC (dmPFC↔BLA PNs). Specifically, CRS shifts dmPFC-driven excitatory-inhibitory balance towards excitation former, but not latter population. Such specificity preferential to connections made dmPFC, caused enhanced presynaptic glutamate release, highly correlated increased anxiety-like behavior stressed mice. Importantly, low-frequency optogenetic stimulation afferents BLA normalizes release onto dmPFC→BLA PNs lastingly attenuates CRS-induced increase behavior. Our findings thus reveal target cell-based mPFC-to-amygdala transmission for stress-induced anxiety.

Язык: Английский

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Animal models of drug relapse and craving

Progress in brain research, Год журнала: 2015, Номер unknown, С. 25 - 52

Опубликована: Ноя. 5, 2015

Язык: Английский

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Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

Physiological Reviews, Год журнала: 2020, Номер 101(2), С. 611 - 681

Опубликована: Сен. 24, 2020

This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.

Язык: Английский

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Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex

Cell, Год журнала: 2017, Номер 171(7), С. 1663 - 1677.e16

Опубликована: Дек. 1, 2017

Язык: Английский

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