
Neuron, Год журнала: 2022, Номер 110(16), С. 2625 - 2645.e7
Опубликована: Июнь 28, 2022
Язык: Английский
Neuron, Год журнала: 2022, Номер 110(16), С. 2625 - 2645.e7
Опубликована: Июнь 28, 2022
Язык: Английский
Cell, Год журнала: 2016, Номер 166(5), С. 1308 - 1323.e30
Опубликована: Авг. 1, 2016
Язык: Английский
Процитировано
1173Annual Review of Neuroscience, Год журнала: 2015, Номер 38(1), С. 221 - 246
Опубликована: Апрель 21, 2015
In the retina, photoreceptors pass visual information to interneurons, which process it and retinal ganglion cells (RGCs). Axons of RGCs then travel through optic nerve, telling rest brain all will ever know about world. Research over past several decades has made clear that most are not merely light detectors, but rather feature send a diverse set parallel, highly processed images world on higher centers. Here, we review progress in classification by physiological, morphological, molecular criteria, making particular effort distinguish those cell types definitive from for is partial. We focus mouse, genetic methods advanced. argue there around 30 RGC can now account well half RGCs. also use examine general problem neuronal classification, arguing insights retina guide enterprise other regions.
Язык: Английский
Процитировано
764Neuron, Год журнала: 2016, Номер 90(3), С. 437 - 451
Опубликована: Май 1, 2016
Язык: Английский
Процитировано
557Neuron, Год журнала: 2019, Номер 104(6), С. 1039 - 1055.e12
Опубликована: Ноя. 26, 2019
Язык: Английский
Процитировано
534Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(6), С. 323 - 337
Опубликована: Апрель 17, 2018
Язык: Английский
Процитировано
512Nature, Год журнала: 2018, Номер 561(7723), С. 396 - 400
Опубликована: Авг. 28, 2018
Язык: Английский
Процитировано
455Nature Communications, Год журнала: 2018, Номер 9(1)
Опубликована: Июль 11, 2018
Retinal ganglion cells (RGCs) convey the major output of information collected from eye to brain. Thirty subtypes RGCs have been identified date. Here, we analyze 6225 (average 5000 genes per cell) right and left eyes by single-cell RNA-seq classify them into 40 using clustering algorithms. We identify additional markers, as well transcription factors predicted cooperate in specifying RGC subtypes. Zic1, a marker eye-enriched subtype, is validated immunostaining situ. Runx1 Fst, markers other subtypes, are purified fluorescent situ hybridization (FISH) immunostaining. show extent gene expression variability needed for subtype segregation, hierarchy diversification cell-type population Finally, present website comparing
Язык: Английский
Процитировано
394Stem Cells Translational Medicine, Год журнала: 2017, Номер 6(4), С. 1273 - 1285
Опубликована: Янв. 26, 2017
Abstract The loss of retinal ganglion cells (RGC) and their axons is one the leading causes blindness includes traumatic (optic neuropathy) degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem (MSC) have demonstrated significant neuroprotective axogenic effects on RGC both aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30–100 nm) containing proteins, mRNA miRNA which can be delivered to nearby cells. present study aimed isolate exosomes from bone marrow-derived (BMSC) test them a rat optic nerve crush (ONC) model. Treatment primary cultures with BMSC-exosomes neuritogenic effects. Twenty-one days after ONC weekly intravitreal exosome injections; optical coherence tomography, electroretinography, immunohistochemistry was performed. BMSC-derived promoted statistically survival regeneration while partially preventing axonal dysfunction. Exosomes successfully cargo into inner layers were reliant miRNA, by diminished therapeutic derived BMSC knockdown Argonaute-2, key effector molecule. This supports use as cell-free therapy for ocular disease.
Язык: Английский
Процитировано
390Neuron, Год журнала: 2018, Номер 97(2), С. 313 - 325.e6
Опубликована: Янв. 1, 2018
Язык: Английский
Процитировано
354Nature Neuroscience, Год журнала: 2016, Номер 19(8), С. 1073 - 1084
Опубликована: Июль 12, 2016
Язык: Английский
Процитировано
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