Not just amyloid: physiological functions of the amyloid precursor protein family

Nature reviews. Neuroscience, Год журнала: 2017, Номер 18(5), С. 281 - 298

Опубликована: Март 31, 2017

Язык: Английский

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Architecture, Function, and Assembly of the Mouse Visual System

Annual Review of Neuroscience, Год журнала: 2017, Номер 40(1), С. 499 - 538

Опубликована: Июль 25, 2017

Vision is the sense humans rely on most to navigate world, make decisions, and perform complex tasks. Understanding how see thus represents one of fundamental important goals neuroscience. The use mouse as a model for parsing vision works at level started approximately decade ago, ushered in by mouse's convenient size, relatively low cost, and, above all, amenability genetic perturbations. In course that effort, large cadre new powerful tools vivo labeling, monitoring, manipulation neurons were applied this species. As consequence, significant body work now exists architecture, function, development central visual pathways. Excitingly, much includes causal testing role specific cell types circuits perception behavior-something rare find studies system other Indeed, could argue more information available about than any sensory system, species, including humans. such, has become platform multilevel analysis mammalian nervous generally. Here we review structure, literature comment similarities differences between We also it point highlight aspects circuitry remain opaque are need additional experimentation enrich our understanding broad scale.

Язык: Английский

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Neural activity promotes long-distance, target-specific regeneration of adult retinal axons

Nature Neuroscience, Год журнала: 2016, Номер 19(8), С. 1073 - 1084

Опубликована: Июль 12, 2016

Язык: Английский

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Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

Cell Reports, Год журнала: 2020, Номер 31(12), С. 107776 - 107776

Опубликована: Июнь 1, 2020

Glaucoma is a neurodegenerative disease that features the death of retinal ganglion cells (RGCs) in retina, often as result prolonged increases intraocular pressure. We show preventing formation neuroinflammatory reactive astrocytes prevents RGCs normally seen mouse model glaucoma. Furthermore, we these spared are electrophysiologically functional and thus still have potential value for function regeneration retina. Finally, demonstrate depends on combination both an injury to neurons presence astrocytes, suggesting may explain why toxic only some circumstances. Altogether, findings highlight drivers RGC chronic eye.

Язык: Английский

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Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity

Neuron, Год журнала: 2015, Номер 89(1), С. 177 - 193

Опубликована: Дек. 18, 2015

Neuronal circuit asymmetries are important components of brain circuits, but the molecular pathways leading to their establishment remain unknown. Here we found that mutation FRMD7, a gene is defective in human congenital nystagmus, leads selective loss horizontal optokinetic reflex mice, as it does humans. This accompanied by direction selectivity retinal ganglion cells and transition from asymmetric symmetric inhibitory input direction-selective cells. In wild-type retinas, FRMD7 specifically expressed starburst amacrine cells, interneuron type provides inhibition work identifies key regulator establishing neuronal asymmetry, suggests involvement specific neuron pathophysiology neurological disease.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiIzMmUzNGJkNWNlNDFiZDEyNzJiYThlZDEzMzdkMTU1MCIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NjUxMTk0fQ.c7cbIpedz5yPxIls2CJule0S7s6X07WWKZAWW5_ordQ9xIgRHZwKIH3L1LsPim7D3ZdOUHyIu2CI1Ub7QaxeGVUcSenZXjDHETUUra1xVz2f_HgGO8UHUgnuBirxb75GxNOka35b4u2G57Q6jiyu3X8emPXluNYdGbVDNDAuJuedSAoZbkaxut5PQs3W6W1HLuiB04Wfa5If5fSqeZnY_rBEcsww7nAnRqHvVKAKX8i7x93F_jjt-UFu0iX1EByCmWT8j_jBO08kCtmNrJ_qVPTnC0Kr8v1hFcEVKYHgJuwmw3VHjxhCLTokdwqkuUmJWpKp_dUeHFNjmi4vR_gbaQ(mp4, (47.53 MB) Download video

Язык: Английский

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Organization of the dorsal lateral geniculate nucleus in the mouse

Visual Neuroscience, Год журнала: 2017, Номер 34

Опубликована: Янв. 1, 2017

Abstract The dorsal lateral geniculate nucleus (dLGN) of the thalamus is principal conduit for visual information from retina to cortex. Viewed initially as a simple relay, recent studies in mouse reveal far greater complexity way input combined, transmitted, and processed dLGN. Here we consider structural functional organization retinogeniculate pathway by examining patterns retinal projections dLGN how they converge onto thalamocortical neurons shape flow

Язык: Английский

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Functional Assembly of Accessory Optic System Circuitry Critical for Compensatory Eye Movements

Neuron, Год журнала: 2015, Номер 86(4), С. 971 - 984

Опубликована: Май 1, 2015

Язык: Английский

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Feature Detection by Retinal Ganglion Cells

Annual Review of Vision Science, Год журнала: 2022, Номер 8(1), С. 135 - 169

Опубликована: Апрель 6, 2022

Retinal circuits transform the pixel representation of photoreceptors into feature representations ganglion cells, whose axons transmit these to brain. Functional, morphological, and transcriptomic surveys have identified more than 40 retinal cell (RGC) types in mice. RGCs extract features varying complexity; some simply signal local differences brightness (i.e., luminance contrast), whereas others detect specific motion trajectories. To understand retina, we need know how give rise diverse RGC representations. A catalog set, turn, is fundamental understanding visual processing Anterograde tracing indicates that innervate 50 areas mouse Current maps connecting brain are rudimentary, as our signals transformed downstream guide behavior. In this article, I review selectivities RGCs, they arise, utilized downstream. Not only knowledge behavioral purpose critical for contributions vision; it can also us most relevant space.

Язык: Английский

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Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10

Опубликована: Июль 26, 2022

Alzheimer's disease (AD) is an incurable neurodegenerative disorder in which dysfunction and loss of synapses neurons lead to cognitive impairment death. Accumulation aggregation neurotoxic amyloid-β (Aβ) peptides generated via amyloidogenic processing amyloid precursor protein (APP) considered play a central role the etiology. APP interacts with cell adhesion molecules, influence normal physiological functions APP, its non-amyloidogenic processing, formation Aβ aggregates. These surface glycoproteins also mediate attachment neuronal induce intracellular signaling contributing toxicity. In this review, we discuss current knowledge surrounding interactions molecules analyze evidence critical these proteins regulating function as well This necessary piece complex AD puzzle, should understand order develop safe effective therapeutic interventions for AD.

Язык: Английский

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Electric field stimulation directs target-specific axon regeneration and partial restoration of vision after optic nerve crush injury

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0315562 - e0315562

Опубликована: Янв. 9, 2025

Failure of central nervous system (CNS) axons to regenerate after injury results in permanent disability. Several molecular neuro-protective and neuro-regenerative strategies have been proposed as potential treatments but do not provide the directional cues needed direct target-specific axon regeneration. Here, we demonstrate that applying an external guidance cue form electric field stimulation adult rats optic nerve crush was effective at directing long-distance, retinal ganglion cell (RGC) regeneration native targets diencephalon. Stimulation performed with asymmetric charged-balanced (ACB) waveforms are safer than current more traditional, symmetric biphasic waveforms. In addition partial anatomical restoration, ACB conferred restoration visual function measured by pattern electroretinogram recordings local superior colliculus—and did so without need for genetic manipulation. Our work suggests exogenous application can override cell-intrinsic cell-extrinsic barriers regeneration, electrical specific may be strategy functional CNS injury.

Язык: Английский

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