Advanced Materials,
Год журнала:
2017,
Номер
29(13)
Опубликована: Фев. 10, 2017
An
artificial
ionic
mechanotransducer
skin
with
an
unprecedented
sensitivity
over
a
wide
spectrum
of
pressure
by
fabricating
visco-poroelastic
nanochannels
and
microstructured
features,
directly
mimicking
the
physiological
tactile
sensing
mechanism
Piezo2
protein
is
demonstrated.
This
capability
enables
voice
identification,
health
monitoring,
daily
measurements,
even
measurements
heavy
weight
beyond
capabilities
human
skin.
As
service
to
our
authors
readers,
this
journal
provides
supporting
information
supplied
authors.
Such
materials
are
peer
reviewed
may
be
re-organized
for
online
delivery,
but
not
copy-edited
or
typeset.
Technical
support
issues
arising
from
(other
than
missing
files)
should
addressed
Please
note:
The
publisher
responsible
content
functionality
any
Any
queries
content)
directed
corresponding
author
article.
Physiological Reviews,
Год журнала:
2018,
Номер
98(2), С. 559 - 621
Опубликована: Фев. 7, 2018
Genomic
instability
is
a
primary
cause
and
fundamental
feature
of
human
cancer.
However,
all
cancer
cell
genotypes
generally
translate
into
several
common
pathophysiological
features,
often
referred
to
as
hallmarks.
Although
nowadays
the
catalog
hallmarks
quite
broad,
most
obvious
them
are
1)
uncontrolled
proliferation,
2)
resistance
programmed
death
(apoptosis),
3)
tissue
invasion
metastasis,
4)
sustained
angiogenesis.
Among
genes
affected
by
cancer,
those
encoding
ion
channels
present.
Membrane
proteins
responsible
for
signaling
within
among
cells,
coupling
extracellular
events
with
intracellular
responses,
maintaining
ionic
homeostasis
contribute
various
extents
features
each
hallmark.
Moreover,
tight
association
these
channel
dysfunction
gives
good
reason
classify
special
type
channelopathies,
namely
oncochannelopathies.
relation
differs
from
classical
definition
disease
states
causally
linked
inherited
mutations
that
alter
channel's
biophysical
properties,
in
broader
context
state,
which
pathogenesis
essentially
contribute,
such
classification
seems
absolutely
appropriate.
In
this
review
authors
provide
arguments
substantiate
point
view.
