Persistence of Amygdala–Hippocampal Connectivity and Multi-Voxel Correlation Structures During Awake Rest After Fear Learning Predicts Long-Term Expression of Fear

Cerebral Cortex, Год журнала: 2016, Номер unknown, С. bhw145 - bhw145

Опубликована: Май 30, 2016

After encoding, memories undergo a process of consolidation that determines long-term retention. For conditioned fear, animal models postulate involves reactivations neuronal assemblies supporting fear learning during postlearning "offline" periods. However, no human studies to date have investigated such processes, particularly in relation expression fear. We tested 24 participants using functional MRI on 2 consecutive days conditioning paradigm involving 1 habituation block, acquisition blocks, and extinction blocks day 1, re-extinction 2. Conditioning were preceded followed by 4.5-min rest blocks. Strength spontaneous recovery served as measure Amygdala connectivity primarily with hippocampus increased progressively postacquisition postextinction 1. Intraregional multi-voxel correlation structures within amygdala sampled block differential furthermore persisted after learning. Critically, both these main findings stronger who exhibited h later. Our indicate neural circuits activated exhibit persistent activity may be functionally relevant promoting the memory.

Язык: Английский

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Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

Journal of Neuroinflammation, Год журнала: 2020, Номер 17(1)

Опубликована: Июль 7, 2020

Abstract Background Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- stress-related disorders such as posttraumatic stress disorder (PTSD) anxiety disorder. Despite the abundant discoveries of neuroinflammation in disorders, underlying mechanisms still remain unclear. Method Wild-type Nlrp3 −/− mice were exposed to electric foot shocks contextual fear memory paradigm. Three hours after shocks, activation NLRP3 inflammasome was investigated through immunoblotting ELISA. Microglia isolated analyzed by quantitative real-time PCR. Hippocampal tissues collected 3 h 72 subjected RNA sequencing. MCC950 administrated via intraperitoneal (i.p.) injection. Interleukin-1 receptor antagonist (IL-ra) interleukin-1β (IL-1β) delivered intracerebroventricular (i.c.v.) infusion. Contextual responses tested on 4 consecutive days (test 1-4) starting at 48 shocks. Anxiety-like behaviors examined elevated plus maze open-field test. Results We demonstrated that, paradigm, activated also found an upregulation toll-like RIG-I-like signaling, a decrease postsynaptic density (PSD) related proteins, PSD95 Shank hippocampus indicating association between PSD protein loss encounter. Meanwhile, knockout could significantly prevent both PSD-related suggesting possible protective role deletion during this process. For further studies, we that genetic pharmaceutical inhibition remarkably enhanced extinction attenuated anxiety-like behavior caused Moreover, cytokine IL-1β administration inhibited memory. IL-1ra behavior. Conclusion Taken together, our data revealed pivotal regulation development PTSD disorder, providing novel target for clinical treatment disorders.

Язык: Английский

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Stress and memory retrieval: mechanisms and consequences

Current Opinion in Behavioral Sciences, Год журнала: 2016, Номер 14, С. 40 - 46

Опубликована: Дек. 24, 2016

Язык: Английский

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Role of Human Ventromedial Prefrontal Cortex in Learning and Recall of Enhanced Extinction

Journal of Neuroscience, Год журнала: 2019, Номер 39(17), С. 3264 - 3276

Опубликована: Фев. 19, 2019

Standard fear extinction relies on the ventromedial prefrontal cortex (vmPFC) to form a new memory given omission of threat. Using fMRI in humans, we investigated whether replacing threat with novel neutral outcomes (instead just omitting threat) facilitates by engaging vmPFC more effectively than standard extinction. Computational modeling associability (indexing surprise strength and dynamically modulating learning rates) characterized skin conductance responses activity during novelty-facilitated but not Subjects who showed faster within-session updating also expressed better retention next day, as through responses. Finally, separable patterns connectivity between amygdala ventral versus dorsal mPFC retrieval memories, respectively. These results indicate that stimulates involvement trials, leading durable long-term memory. SIGNIFICANCE STATEMENT Psychiatric disorders be excessive are major public health concern. Popular clinical treatments, such exposure therapy, informed principles Pavlovian Thus, there is motivation optimize strategies laboratory so ultimately develop effective treatments. Here, used functional neuroimaging humans found (rather omitting) expected aversive events engages learning. Enhanced diminished threat-related networks (e.g., insula, thalamus) immediate 24 h test. This evidence for how behavioral protocols designed enhance affects neurocircuitry underlying memories.

Язык: Английский

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Behavioral and neural processes in counterconditioning: Past and future directions

Behaviour Research and Therapy, Год журнала: 2019, Номер 125, С. 103532 - 103532

Опубликована: Дек. 12, 2019

Язык: Английский

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