Brain Sciences,
Год журнала:
2021,
Номер
11(9), С. 1199 - 1199
Опубликована: Сен. 11, 2021
Dopamine
is
an
important
neurotransmitter
that
plays
a
key
role
in
neuropsychiatric
illness.
Sex
differences
dopaminergic
signaling
have
been
acknowledged
for
decades
and
linked
to
sex-specific
heterogeneity
both
dopamine-related
behaviours
as
well
various
disorders.
However,
the
overall
number
of
studies
evaluated
sex
dopamine
signaling,
health
these
disorders,
low.
This
review
will
bring
together
what
known
regarding
innate
receptor
expression
function,
highlight
roles
addiction,
depression,
anxiety,
schizophrenia,
attention
deficit
hyperactivity
disorder.
Due
prognosis,
diagnosis,
symptomatology
between
male
female
subjects
disorders
involve
or
responses
utilize
pharmacological
interventions
target
receptors,
understanding
fundamental
receptors
vital
importance
personalization
therapeutic
treatment
strategies.
Nature Communications,
Год журнала:
2017,
Номер
8(1)
Опубликована: Окт. 20, 2017
Early-life
stress,
including
maternal
separation
(MS),
increases
the
vulnerability
to
develop
mood
disorders
later
in
life,
but
underlying
mechanisms
remain
elusive.
We
report
that
MS
promotes
depressive-like
symptoms
mice
at
a
mature
stage
of
life.
Along
with
this
behavioral
phenotype,
drives
reduction
GABAB-GIRK
signaling
and
subsequent
lateral
habenula
(LHb)
hyperexcitability-an
anatomical
substrate
devoted
aversive
encoding.
Attenuating
LHb
hyperactivity
using
chemogenetic
tools
deep-brain
stimulation
ameliorates
symptoms.
This
provides
insights
on
strategies
alleviate
stress-dependent
affective
behaviors.
Proceedings of the National Academy of Sciences,
Год журнала:
2019,
Номер
116(18), С. 9066 - 9071
Опубликована: Апрель 15, 2019
Significance
Addiction
is
characterized
by
compulsive
drug
use
despite
negative
consequences.
In
a
rat
model
of
methamphetamine
self-administration,
we
found
that
compulsive-like
taking
was
correlated
with
alterations
in
the
balance
between
an
increased
orbitofrontal
cortex-dorsomedial
striatal
“go”
circuit
and
decreased
prelimbic
cortex-ventrolateral
“stop”
only
addictive-like
subgroup
resistant
to
foot
shock
punishment
paired
taking.
nonaddictive-like
rats,
go-stop
balance,
which
similarly
changed
after
repeated
self-administration
without
punishment,
normalized
toward
baseline
levels
punishment.
These
results
indicate
restoring
physiological
perhaps
noninvasive
brain
stimulation,
may
provide
promising
avenue
for
addiction
treatment
when
coupled
neuroimaging
assess
clinical
responses
determine
adequacy
course
treatment.
Science,
Год журнала:
2021,
Номер
373(6560), С. 1252 - 1256
Опубликована: Сен. 9, 2021
Compulsive
drug
use
despite
adverse
consequences
defines
addiction.
While
mesolimbic
dopamine
signaling
is
sufficient
to
drive
compulsion,
psychostimulants
such
as
cocaine
also
boost
extracellular
serotonin
(5-HT)
by
inhibiting
reuptake.
We
used
SERT
Met172
knockin
(SertKI)
mice
carrying
a
transporter
that
no
longer
binds
abolish
5-HT
transients
during
self-administration.
SertKI
showed
an
enhanced
transition
compulsion.
Conversely,
pharmacologically
elevating
reversed
the
inherently
high
rate
of
compulsion
with
optogenetic
self-stimulation.
The
bidirectional
effect
on
behavior
explained
presynaptic
depression
orbitofrontal
cortex–to–dorsal
striatum
synapses
induced
via
Brain Sciences,
Год журнала:
2021,
Номер
11(9), С. 1199 - 1199
Опубликована: Сен. 11, 2021
Dopamine
is
an
important
neurotransmitter
that
plays
a
key
role
in
neuropsychiatric
illness.
Sex
differences
dopaminergic
signaling
have
been
acknowledged
for
decades
and
linked
to
sex-specific
heterogeneity
both
dopamine-related
behaviours
as
well
various
disorders.
However,
the
overall
number
of
studies
evaluated
sex
dopamine
signaling,
health
these
disorders,
low.
This
review
will
bring
together
what
known
regarding
innate
receptor
expression
function,
highlight
roles
addiction,
depression,
anxiety,
schizophrenia,
attention
deficit
hyperactivity
disorder.
Due
prognosis,
diagnosis,
symptomatology
between
male
female
subjects
disorders
involve
or
responses
utilize
pharmacological
interventions
target
receptors,
understanding
fundamental
receptors
vital
importance
personalization
therapeutic
treatment
strategies.
