Physiological Reviews,
Год журнала:
2021,
Номер
102(1), С. 343 - 378
Опубликована: Июль 19, 2021
In
mammals,
the
selective
transformation
of
transient
experience
into
stored
memory
occurs
in
hippocampus,
which
develops
representations
specific
events
context
they
occur.
this
review,
we
focus
on
development
hippocampal
circuits
and
self-organized
dynamics
embedded
within
them
since
latter
critically
support
role
hippocampus
learning
memory.
We
first
discuss
evidence
that
adult
cells
are
sculpted
by
as
early
during
embryonic
neurogenesis.
argue
these
primary
developmental
programs
provide
a
scaffold
onto
later
external
world
can
be
grafted.
Next,
review
different
sequences
at
anatomical
functional
levels.
cover
period
extending
from
neurogenesis
migration
to
appearance
phenotypic
diversity
their
wiring
networks.
describe
progressive
emergence
network
sensorimotor-driven
sharp
waves
place
tracking
relational
information.
outline
critical
turn
points
discontinuities
journey,
close
formulating
open
questions.
propose
rewinding
process
helps
understand
main
organization
principles
circuits.
Journal of Neuroscience,
Год журнала:
2016,
Номер
36(48), С. 12259 - 12275
Опубликована: Ноя. 30, 2016
A
comprehensive
developmental
timeline
of
activity
in
the
mouse
cortex
vivo
is
lacking.
Understanding
changes
that
accompany
synapse
and
circuit
formation
important
to
understand
mechanisms
by
which
molds
circuits
would
help
identify
critical
checkpoints
for
normal
development.
To
key
principles
cortical
maturation,
we
systematically
tracked
spontaneous
sensory-evoked
with
extracellular
recordings
primary
visual
(V1)
nonanesthetized
mice.
During
first
postnatal
week
(postnatal
days
P4-P7),
V1
was
not
visually
responsive
exhibited
long
(>10
s)
periods
network
silence.
Activation
consisted
exclusively
"slow-activity
transients,"
2-10
s
6-10
Hz
"spindle-burst'
oscillations;
response
retinal
waves.
By
tracking
daily
this
activity,
two
components
maturation
were
revealed:
(1)
spindle-burst
frequency
acceleration
(eventually
becoming
20-50
broadband
caused
asynchronous
state)
(2)
"filling-in"
silent
low-frequency
(2-4
Hz)
(beginning
on
P10
complete
P13).
These
are
sufficient
create
adult-like
pattern
continuous
alternation
between
fast-asynchronous
slow-synchronous
eye
opening.
Visual
responses
emerged
P8
as
evoked
spindle-bursts
neuronal
firing
a
signal-to-noise
ratio
higher
than
adult.
Both
eliminated
opening,
leaving
only
mature,
short-latency
response.
results
origins
mature
implicate
period
before
opening
checkpoint.
providing
systematic
description
electrical
development,
establish
murine
model
electroencephalographic
development
fetal
humans.Cortical
an
indicator
long-term
health
survival
preterm
infants
formation,
but
gaps
remain
our
understanding
origin
progression
developing
cortex.
We
aimed
rectify
monitoring
mouse,
preclinical
disease
At
ages
approximately
equivalent
human
term
birth,
exhibits
primarily
silence,
"spindle
bursts"
form
activity.
In
contrast,
noisy,
alternating
asynchronous/discontinuous
synchronous/continuous
states.
This
work
identifies
processes
produce
provides
normative
reference
murine-based
studies
Physiological Reviews,
Год журнала:
2021,
Номер
102(1), С. 343 - 378
Опубликована: Июль 19, 2021
In
mammals,
the
selective
transformation
of
transient
experience
into
stored
memory
occurs
in
hippocampus,
which
develops
representations
specific
events
context
they
occur.
this
review,
we
focus
on
development
hippocampal
circuits
and
self-organized
dynamics
embedded
within
them
since
latter
critically
support
role
hippocampus
learning
memory.
We
first
discuss
evidence
that
adult
cells
are
sculpted
by
as
early
during
embryonic
neurogenesis.
argue
these
primary
developmental
programs
provide
a
scaffold
onto
later
external
world
can
be
grafted.
Next,
review
different
sequences
at
anatomical
functional
levels.
cover
period
extending
from
neurogenesis
migration
to
appearance
phenotypic
diversity
their
wiring
networks.
describe
progressive
emergence
network
sensorimotor-driven
sharp
waves
place
tracking
relational
information.
outline
critical
turn
points
discontinuities
journey,
close
formulating
open
questions.
propose
rewinding
process
helps
understand
main
organization
principles
circuits.
