Dialogues in Clinical Neuroscience,
Год журнала:
2020,
Номер
22(3), С. 207 - 222
Опубликована: Сен. 30, 2020
The
endocannabinoid
system
(ECS)
is
a
highly
versatile
signaling
within
the
nervous
system.
Despite
its
widespread
localization,
functions
context
of
distinct
neural
processes
are
very
well
discernable
and
specific.
This
remarkable,
question
remains
as
to
how
such
specificity
achieved.
One
key
player
in
ECS
cannabinoid
type
1
receptor
(CB1),
G
protein–coupled
characterized
by
complexity
cell-specific
expression,
cellular
subcellular
adaptable
regulation
intracellular
cascades.
CB1
receptors
involved
different
synaptic
plasticity
brain's
bioenergetics
context-specific
manner.
CB2
also
important
several
neurons,
glial
cells,
immune
cells
brain.
As
polymorphisms
components,
external
impacts
stress
metabolic
challenges,
can
both
lead
dysregulated
activity
subsequently
possible
neuropsychiatric
disorders,
pharmacological
intervention
targeting
promising
therapeutic
approach.
Understanding
neurobiology
depth
will
aid
optimal
design
interventions,
minimizing
unwanted
side
effects.
Proceedings of the National Academy of Sciences,
Год журнала:
2016,
Номер
113(41), С. 11615 - 11620
Опубликована: Сен. 26, 2016
The
tight
spatial
coupling
of
synaptic
vesicles
and
voltage-gated
Ca2+
channels
(CaVs)
ensures
efficient
action
potential-triggered
neurotransmitter
release
from
presynaptic
active
zones
(AZs).
Rab-interacting
molecule-binding
proteins
(RIM-BPs)
interact
with
via
RIM
other
components
the
machinery.
Although
human
RIM-BPs
have
been
implicated
in
autism
spectrum
disorders,
little
is
known
about
role
mammalian
transmission.
We
investigated
RIM-BP2-deficient
murine
hippocampal
neurons
cultures
slices.
Short-term
facilitation
significantly
enhanced
both
model
systems.
Detailed
analysis
culture
revealed
a
reduction
initial
probability,
which
presumably
underlies
increased
short-term
facilitation.
Superresolution
microscopy
an
impairment
CaV2.1
clustering
at
AZs,
likely
alters
nanodomains
sites
thereby
affects
probability.
Additional
deletion
RIM-BP1
does
not
exacerbate
phenotype,
indicating
that
RIM-BP2
dominating
RIM-BP
isoform
these
synapses.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(11), С. 5431 - 5431
Опубликована: Май 21, 2021
Endocannabinoids
(eCBs)
are
lipid-based
retrograde
messengers
with
a
relatively
short
half-life
that
produced
endogenously
and,
upon
binding
to
the
primary
cannabinoid
receptors
CB1/2,
mediate
multiple
mechanisms
of
intercellular
communication
within
body.
Endocannabinoid
signaling
is
implicated
in
brain
development,
memory
formation,
learning,
mood,
anxiety,
depression,
feeding
behavior,
analgesia,
and
drug
addiction.
It
now
recognized
endocannabinoid
system
mediates
not
only
neuronal
communications
but
also
governs
crosstalk
between
neurons,
glia,
immune
cells,
thus
represents
an
important
player
neuroimmune
interface.
Generation
endocannabinoids
accompanied
by
production
their
congeners,
N-acylethanolamines
(NAEs),
which
together
N-acylneurotransmitters,
lipoamino
acids
fatty
acid
amides
comprise
expanded
endocannabinoid/endovanilloid
systems.
Most
these
compounds
do
bind
signal
via
several
other
pathways
involving
transient
receptor
potential
cation
channel
subfamily
V
member
1
(TRPV1),
peroxisome
proliferator-activated
(PPAR)-α
non-cannabinoid
G-protein
coupled
(GPRs)
anti-inflammatory,
immunomodulatory
neuroprotective
activities.
In
vivo
generation
triggered
physiological
pathological
stimuli
specifically
brain,
fine
regulation
synaptic
strength,
neuroprotection,
resolution
neuroinflammation.
Here,
we
review
role
intrinsic
its
therapeutic
for
treatment
neuroinflammation
associated
synaptopathy.
Dialogues in Clinical Neuroscience,
Год журнала:
2020,
Номер
22(3), С. 207 - 222
Опубликована: Сен. 30, 2020
The
endocannabinoid
system
(ECS)
is
a
highly
versatile
signaling
within
the
nervous
system.
Despite
its
widespread
localization,
functions
context
of
distinct
neural
processes
are
very
well
discernable
and
specific.
This
remarkable,
question
remains
as
to
how
such
specificity
achieved.
One
key
player
in
ECS
cannabinoid
type
1
receptor
(CB1),
G
protein–coupled
characterized
by
complexity
cell-specific
expression,
cellular
subcellular
adaptable
regulation
intracellular
cascades.
CB1
receptors
involved
different
synaptic
plasticity
brain's
bioenergetics
context-specific
manner.
CB2
also
important
several
neurons,
glial
cells,
immune
cells
brain.
As
polymorphisms
components,
external
impacts
stress
metabolic
challenges,
can
both
lead
dysregulated
activity
subsequently
possible
neuropsychiatric
disorders,
pharmacological
intervention
targeting
promising
therapeutic
approach.
Understanding
neurobiology
depth
will
aid
optimal
design
interventions,
minimizing
unwanted
side
effects.
