Surviving threats: neural circuit and computational implications of a new taxonomy of defensive behaviour

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(5), С. 269 - 282

Опубликована: Март 29, 2018

Язык: Английский

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Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

Physiological Reviews, Год журнала: 2020, Номер 101(2), С. 611 - 681

Опубликована: Сен. 24, 2020

This article reviews the behavioral neuroscience of extinction, phenomenon in which a behavior that has been acquired through Pavlovian or instrumental (operant) learning decreases strength when outcome reinforced it is removed. Behavioral research indicates neither nor operant extinction depends substantially on erasure original but instead new inhibitory primarily expressed context learned, as exemplified by renewal effect. Although nature inhibition may differ and either case decline responding depend both generalization decrement correction prediction error. At neural level, requires tripartite circuit involving amygdala, prefrontal cortex, hippocampus. Synaptic plasticity amygdala essential for learning, cortical neurons encoding fear memories involved retrieval. Hippocampal-prefrontal circuits mediate relapse phenomena, including renewal. Instrumental involves distinct ensembles corticostriatal, striatopallidal, striatohypothalamic well their thalamic returns (extinction) excitatory (renewal other phenomena) control over responding. The field made significant progress recent decades, although fully integrated biobehavioral understanding still awaits.

Язык: Английский

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Encoding of contextual fear memory in hippocampal–amygdala circuit

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Март 13, 2020

Abstract In contextual fear conditioning, experimental subjects learn to associate a neutral context with an aversive stimulus and display responses that predicts danger. Although the hippocampal–amygdala pathway has been implicated in retrieval of memory, mechanism by which memory is encoded this circuit not investigated. Here, we show activity ventral CA1 (vCA1) hippocampal projections basal amygdala (BA), paired stimuli, contributes encoding conditioned memory. Contextual conditioning induced selective strengthening subset vCA1–BA synapses, was prevented under anisomycin-induced retrograde amnesia. Moreover, subpopulation BA neurons receives stronger monosynaptic inputs from context-responding vCA1 neurons, whose required for learning synaptic potentiation pathway. Our study suggests conveying information adaptive threat-predictive context.

Язык: Английский

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Integration of Parallel Opposing Memories Underlies Memory Extinction

Cell, Год журнала: 2018, Номер 175(3), С. 709 - 722.e15

Опубликована: Сен. 20, 2018

Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show extinction of aversive memories in Drosophila specific dopaminergic neurons, which indicate omission punishment is remembered as positive Functional imaging revealed co-existence intracellular calcium traces different places the mushroom body output neuron network for both original new appetitive memory. Light ultrastructural anatomy are consistent with parallel competing being combined within neurons direct avoidance. Indeed, extinction-evoked plasticity pair these neutralizes potentiated odor response imposed learning. Therefore, flies track accuracy expectations accumulating integrating events.

Язык: Английский

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Synapse-specific representation of the identity of overlapping memory engrams

Science, Год журнала: 2018, Номер 360(6394), С. 1227 - 1231

Опубликована: Июнь 14, 2018

Disentangling specific memories Each memory is stored in a distinct trace the brain, population of neurons called engram cells. How does brain store and define identity when two interact are encoded shared engram? Abdou et al. used optogenetic reactivation coupled with manipulations long-term potentiation to analyze engrams that share lateral amygdala (see Perspective by Ramirez). Synapse-specific plasticity guaranteed storage individual engram. Moreover, synaptic between assemblies was necessary sufficient for formation. Science , this issue p. 1227 ; see also 1182

Язык: Английский

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Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Trends in Neurosciences, Год журнала: 2019, Номер 42(7), С. 458 - 470

Опубликована: Июнь 4, 2019

Язык: Английский

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The role of gamma oscillations in central nervous system diseases: Mechanism and treatment

Frontiers in Cellular Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Июль 29, 2022

Gamma oscillation is the synchronization with a frequency of 30-90 Hz neural oscillations, which are rhythmic electric processes neuron groups in brain. The inhibitory interneuron network necessary for production gamma but certain disruptions such as brain inflammation, oxidative stress, and metabolic imbalances can cause this to malfunction. oscillations specifically control connectivity between different regions, crucial perception, movement, memory, emotion. Studies have linked abnormal conditions central nervous system, including Alzheimer's disease, Parkinson's schizophrenia. Evidence suggests that entrainment using sensory stimuli (GENUS) provides significant neuroprotection. This review discusses function advanced activities from both physiological pathological standpoint, it emphasizes potential therapeutic approach range neuropsychiatric diseases.

Язык: Английский

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Synaptic encoding of fear memories in the amygdala

Current Opinion in Neurobiology, Год журнала: 2018, Номер 54, С. 54 - 59

Опубликована: Сен. 11, 2018

Язык: Английский

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Removal of perineuronal nets disrupts recall of a remote fear memory

Proceedings of the National Academy of Sciences, Год журнала: 2017, Номер 115(3), С. 607 - 612

Опубликована: Дек. 26, 2017

Significance Perineuronal nets (PNNs), a type of extracellular matrix only found in the central nervous system, wraps tightly around cell soma and proximal dendrites subset neurons. The PNNs are long-lasting structures that restrict plasticity, making them eligible candidates for memory processing. This work demonstrates lateral secondary visual cortex (V2L) essential recall remote fear memory. results suggest role molecules storage retrieval memories.

Язык: Английский

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Long-term potentiation in the hippocampus: discovery, mechanisms and function

Neuroforum, Год журнала: 2018, Номер 24(3), С. A103 - A120

Опубликована: Июль 14, 2018

Abstract In this review we reflect upon our contributions to the study of properties and mechanisms long-term potentiation (LTP) describe some major influences on work. We then go consider whether LTP has fulfilled its early promise providing a compelling account synaptic basis learning memory.

Язык: Английский

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