Microglia: Agents of the CNS Pro-Inflammatory Response DOI Creative Commons
José A. Rodríguez‐Gómez,

Edel Kavanagh,

Pinelopi Engskog-Vlachos

и другие.

Cells, Год журнала: 2020, Номер 9(7), С. 1717 - 1717

Опубликована: Июль 17, 2020

The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative diseases. Though research spans over century, last two decades have increased our understanding exponentially. Here, we discuss phenotypic transformation from homeostatic towards reactive microglia, initiated specific ligand binding pattern recognition receptors including toll-like receptor-4 (TLR4) or triggering expressed on myeloid cells-2 (TREM2), as well signaling pathways triggered such caspase-mediated response. Additionally, new disciplines epigenetics and immunometabolism provided us with more holistic view how changes in DNA methylation, microRNAs, metabolome may influence This review aimed current knowledge different angles, recent highlights role exosomes spreading neuroinflammation emerging techniques positron emission tomography (PET) scanning use human generated induced pluripotent stem cells (iPSCs). Finally, also thoughts impact

Язык: Английский

Microglia and macrophages in brain homeostasis and disease DOI
Qingyun Li, Ben A. Barres

Nature reviews. Immunology, Год журнала: 2017, Номер 18(4), С. 225 - 242

Опубликована: Ноя. 20, 2017

Язык: Английский

Процитировано

1636

Microglia emerge as central players in brain disease DOI
Michael W. Salter, Beth Stevens

Nature Medicine, Год журнала: 2017, Номер 23(9), С. 1018 - 1027

Опубликована: Сен. 1, 2017

Язык: Английский

Процитировано

1485

Microglia in neurodegeneration DOI
Suzanne E. Hickman, Saef Izzy, Pritha Sen

и другие.

Nature Neuroscience, Год журнала: 2018, Номер 21(10), С. 1359 - 1369

Опубликована: Сен. 19, 2018

Язык: Английский

Процитировано

1395

Microglia Biology: One Century of Evolving Concepts DOI Creative Commons
Marco Prinz, Steffen Jung, Josef Priller

и другие.

Cell, Год журнала: 2019, Номер 179(2), С. 292 - 311

Опубликована: Окт. 1, 2019

Язык: Английский

Процитировано

1098

Microglial signatures and their role in health and disease DOI
Oleg Butovsky, Howard L. Weiner

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(10), С. 622 - 635

Опубликована: Сен. 11, 2018

Язык: Английский

Процитировано

779

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning DOI
Carl M. Sellgren, Jessica Gracias, Bradley Watmuff

и другие.

Nature Neuroscience, Год журнала: 2019, Номер 22(3), С. 374 - 385

Опубликована: Фев. 4, 2019

Язык: Английский

Процитировано

641

Brain organoids: advances, applications and challenges DOI Open Access
Xuyu Qian, Hongjun Song, Guo‐li Ming

и другие.

Development, Год журнала: 2019, Номер 146(8)

Опубликована: Апрель 15, 2019

Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems can be used to investigate brain development disorders. Although mimic many key features of early at molecular, cellular, structural functional levels, some aspects development, such formation distinct cortical neuronal layers, gyrification, establishment complex circuitry, not fully recapitulated. Here, we summarize recent advances in organoid methodologies discuss their applications disease modeling. In addition, compare current brain, highlighting currently cannot recapitulated, perspectives for advancing technologies expand applications.

Язык: Английский

Процитировано

545

Microglia innately develop within cerebral organoids DOI Creative Commons

Paul R. Ormel,

Renata Vieira de Sá, Emma J. van Bodegraven

и другие.

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Окт. 3, 2018

Cerebral organoids are 3D stem cell-derived models that can be utilized to study the human brain. The current consensus is cerebral consist of cells derived from neuroectodermal lineage. This limits their value and applicability, as mesodermal-derived microglia important players in neural development disease. Remarkably, here we show innately develop within a organoid model display characteristic ramified morphology. transcriptome response inflammatory stimulation these organoid-grown closely mimic adult acutely isolated post mortem brain tissue. In addition, mediate phagocytosis synaptic material detected inside them. all, our characterizes microglia-containing represents valuable tool for studying interplay between microglia, macroglia, neurons

Язык: Английский

Процитировано

514

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response DOI Creative Commons

Walther Haenseler,

Stephen N. Sansom, Julian Buchrieser

и другие.

Stem Cell Reports, Год журнала: 2017, Номер 8(6), С. 1727 - 1742

Опубликована: Июнь 1, 2017

Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes Alzheimer's, Parkinson's, and motor neuron disease expressed microglia. There is, therefore, a need for authentic, efficient vitro models to study human microglial pathological mechanisms. originate from the yolk sac as MYB-independent macrophages, migrating into developing complete differentiation. Here, we recapitulate ontogeny by highly differentiation of embryonic iPSC-derived macrophages then co-culture them cortical neurons. Co-cultures retain neuronal maturity functionality weeks. Co-culture microglia express key microglia-specific markers disease-relevant genes, develop dynamic ramifications, phagocytic. Upon activation they become more ameboid, releasing multiple microglia-relevant cytokines. Importantly, downregulate pathogen-response pathways, upregulate homeostatic function promote anti-inflammatory pro-remodeling cytokine response than corresponding monocultures, demonstrating that co-cultures preferable modeling authentic physiology.

Язык: Английский

Процитировано

488

Microglia: Immune and non-immune functions DOI
Katharina Borst, Anaëlle Dumas, Marco Prinz

и другие.

Immunity, Год журнала: 2021, Номер 54(10), С. 2194 - 2208

Опубликована: Окт. 1, 2021

Язык: Английский

Процитировано

456