Cells,
Год журнала:
2020,
Номер
9(7), С. 1717 - 1717
Опубликована: Июль 17, 2020
The
pro-inflammatory
immune
response
driven
by
microglia
is
a
key
contributor
to
the
pathogenesis
of
several
neurodegenerative
diseases.
Though
research
spans
over
century,
last
two
decades
have
increased
our
understanding
exponentially.
Here,
we
discuss
phenotypic
transformation
from
homeostatic
towards
reactive
microglia,
initiated
specific
ligand
binding
pattern
recognition
receptors
including
toll-like
receptor-4
(TLR4)
or
triggering
expressed
on
myeloid
cells-2
(TREM2),
as
well
signaling
pathways
triggered
such
caspase-mediated
response.
Additionally,
new
disciplines
epigenetics
and
immunometabolism
provided
us
with
more
holistic
view
how
changes
in
DNA
methylation,
microRNAs,
metabolome
may
influence
This
review
aimed
current
knowledge
different
angles,
recent
highlights
role
exosomes
spreading
neuroinflammation
emerging
techniques
positron
emission
tomography
(PET)
scanning
use
human
generated
induced
pluripotent
stem
cells
(iPSCs).
Finally,
also
thoughts
impact
Annual Review of Cell and Developmental Biology,
Год журнала:
2018,
Номер
34(1), С. 523 - 544
Опубликована: Авг. 8, 2018
An
explosion
of
findings
driven
by
powerful
new
technologies
has
expanded
our
understanding
microglia,
the
resident
immune
cells
central
nervous
system
(CNS).
This
wave
discoveries
fueled
a
growing
interest
in
roles
that
these
play
development
CNS
and
neuropathology
diverse
array
disorders.
In
this
review,
we
discuss
crucial
microglia
shaping
brain—from
their
influence
on
neurons
glia
within
developing
to
synaptic
maturation
brain
wiring—as
well
as
some
obstacles
overcome
when
assessing
contributions
normal
development.
Furthermore,
examine
how
developmental
functions
are
perturbed
or
remerge
neurodevelopmental
neurodegenerative
disease.
Cells,
Год журнала:
2020,
Номер
9(7), С. 1717 - 1717
Опубликована: Июль 17, 2020
The
pro-inflammatory
immune
response
driven
by
microglia
is
a
key
contributor
to
the
pathogenesis
of
several
neurodegenerative
diseases.
Though
research
spans
over
century,
last
two
decades
have
increased
our
understanding
exponentially.
Here,
we
discuss
phenotypic
transformation
from
homeostatic
towards
reactive
microglia,
initiated
specific
ligand
binding
pattern
recognition
receptors
including
toll-like
receptor-4
(TLR4)
or
triggering
expressed
on
myeloid
cells-2
(TREM2),
as
well
signaling
pathways
triggered
such
caspase-mediated
response.
Additionally,
new
disciplines
epigenetics
and
immunometabolism
provided
us
with
more
holistic
view
how
changes
in
DNA
methylation,
microRNAs,
metabolome
may
influence
This
review
aimed
current
knowledge
different
angles,
recent
highlights
role
exosomes
spreading
neuroinflammation
emerging
techniques
positron
emission
tomography
(PET)
scanning
use
human
generated
induced
pluripotent
stem
cells
(iPSCs).
Finally,
also
thoughts
impact
