Perineuronal nets protect long-term memory by limiting activity-dependent inhibition from parvalbumin interneurons DOI Creative Commons
Wei Shi,

Xiangbo Wei,

Xiaofei Wang

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2019, Номер 116(52), С. 27063 - 27073

Опубликована: Дек. 16, 2019

Perineuronal nets (PNNs), a complex of extracellular matrix molecules that mostly surround GABAergic neurons in various brain regions, play critical role synaptic plasticity. The function and cellular mechanisms PNNs memory consolidation reconsolidation processes are still not well understood. We hypothesized protect long-term by limiting feedback inhibition from parvalbumin (PV) interneurons to projection neurons. Using behavioral, electrophysiological, optogenetic approaches, we investigated the fear potentiation (LTP). made discovery formation was promoted events hippocampus (HP), also demonstrated PNN both HP anterior cingulate cortex (ACC) is essential for recent remote memories. Removal resulted evident LTP impairments, which were rescued acute application picrotoxin, GABAA receptor blocker, indicating enhanced cause impairments induced removal. Moreover, removal switched receptor-mediated depression through presynaptic mechanism. Furthermore, reduced activity PV surrounded regulated theta oscillations during consolidation. Finally, optogenetically suppressing impairment caused PNNs. Altogether, these results unveil surrounding protecting contextual regulation neuron GABA release.

Язык: Английский

To Kill a Microglia: A Case for CSF1R Inhibitors DOI
Kim N. Green, Joshua Crapser, Lindsay A. Hohsfield

и другие.

Trends in Immunology, Год журнала: 2020, Номер 41(9), С. 771 - 784

Опубликована: Авг. 10, 2020

Язык: Английский

Процитировано

179

Astrocyte-immune cell interactions in physiology and pathology DOI Creative Commons
Rafael Taeho Han, Rachel D. Kim, Anna V. Molofsky

и другие.

Immunity, Год журнала: 2021, Номер 54(2), С. 211 - 224

Опубликована: Фев. 1, 2021

Язык: Английский

Процитировано

166

Microglia-mediated degradation of perineuronal nets promotes pain DOI Open Access
Shannon Tansley, Ning Gu, Alba Ureña Guzmán

и другие.

Science, Год журнала: 2022, Номер 377(6601), С. 80 - 86

Опубликована: Май 26, 2022

Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to development pain hypersensitivity. How activated selectively enhance activity nociceptive circuits is not well understood. We discovered that injury, degrade extracellular matrix structures, perineuronal nets (PNNs), lamina I horn. Lamina PNNs enwrap spinoparabrachial projection neurons, which integrate information and convey it supraspinal brain regions induce sensation. Degradation by enhances neurons induces pain-related behaviors. Thus, injury-induced degradation a mechanism augment output cause

Язык: Английский

Процитировано

128

Microglia as hackers of the matrix: sculpting synapses and the extracellular space DOI Creative Commons
Joshua Crapser, Miguel A. Arreola, Kate I. Tsourmas

и другие.

Cellular and Molecular Immunology, Год журнала: 2021, Номер 18(11), С. 2472 - 2488

Опубликована: Авг. 19, 2021

Abstract Microglia shape the synaptic environment in health and disease, but synapses do not exist a vacuum. Instead, pre- postsynaptic terminals are surrounded by extracellular matrix (ECM), which together with glia comprise four elements of contemporary tetrapartite synapse model. While research this area is still just beginning, accumulating evidence points toward novel role for microglia regulating ECM during normal brain homeostasis, such processes may, turn, become dysfunctional disease. As it relates to synapses, reported modify perisynaptic matrix, diffuse that surrounds dendritic axonal terminals, as well perineuronal nets (PNNs), specialized reticular formations compact enwrap neuronal subsets stabilize proximal synapses. The interconnected relationship between they embedded suggests alterations one structure necessarily affect dynamics other, may need sculpt within. Here, we provide an overview microglial regulation PNNs, propose candidate mechanisms these structures be modified, present implications modifications homeostasis

Язык: Английский

Процитировано

107

Intrinsic activity development unfolds along a sensorimotor–association cortical axis in youth DOI
Valerie J. Sydnor,

Bart Larsen,

Jakob Seidlitz

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(4), С. 638 - 649

Опубликована: Март 27, 2023

Язык: Английский

Процитировано

107

The extracellular matrix and perineuronal nets in memory DOI Creative Commons
James W. Fawcett, Marianne Fyhn, Pavla Jendelová

и другие.

Molecular Psychiatry, Год журнала: 2022, Номер 27(8), С. 3192 - 3203

Опубликована: Июнь 27, 2022

Abstract All components of the CNS are surrounded by a diffuse extracellular matrix (ECM) containing chondroitin sulphate proteoglycans (CSPGs), heparan (HSPGs), hyaluronan, various glycoproteins including tenascins and thrombospondin, many other molecules that secreted into ECM bind to components. In addition, some neurons, particularly inhibitory GABAergic parvalbumin-positive (PV) interneurons, more condensed cartilage-like called perineuronal nets (PNNs). PNNs surround soma proximal dendrites as net-like structures synapses. Attention has focused on role in control plasticity, but it is now clear also play an important part modulation memory. this review we summarize ECM, PNNs, types memory their participation pathology. being considered target for treatment impaired There potential targets mainly through sulphation, binding, production CSPGs they contain or digestion sulphated glycosaminoglycans.

Язык: Английский

Процитировано

99

A shift in the mechanisms controlling hippocampal engram formation during brain maturation DOI
Adam I. Ramsaran, Ying Wang,

Ali Golbabaei

и другие.

Science, Год журнала: 2023, Номер 380(6644), С. 543 - 551

Опубликована: Май 4, 2023

The ability to form precise, episodic memories develops with age, young children only able gist-like that lack precision. cellular and molecular events in the developing hippocampus underlie emergence of episodic-like memory are unclear. In mice, absence a competitive neuronal engram allocation process immature precluded formation sparse engrams precise until fourth postnatal week, when inhibitory circuits mature. This age-dependent shift precision involved functional maturation parvalbumin-expressing interneurons subfield CA1 through assembly extracellular perineuronal nets, which is necessary sufficient for onset allocation, formation,

Язык: Английский

Процитировано

79

Control of neuronal excitation–inhibition balance by BMP–SMAD1 signalling DOI Creative Commons
Zeynep Okur, Nadia Schlauri, Vassilis Bitsikas

и другие.

Nature, Год журнала: 2024, Номер 629(8011), С. 402 - 409

Опубликована: Апрель 17, 2024

Abstract Throughout life, neuronal networks in the mammalian neocortex maintain a balance of excitation and inhibition, which is essential for computation 1,2 . Deviations from balanced state have been linked to neurodevelopmental disorders, severe disruptions result epilepsy 3–5 To balance, microcircuits composed excitatory inhibitory neurons sense alterations neural activity adjust connectivity function. Here we identify signalling pathway adult mouse that activated response increased network activity. Overactivation signalled through an increase levels BMP2, growth factor well known its role as morphogen embryonic development. BMP2 acts on parvalbumin-expressing (PV) interneurons transcription SMAD1, controls array glutamatergic synapse proteins components perineuronal nets. PV-interneuron-specific disruption BMP2–SMAD1 accompanied by loss innervation PV cells, underdeveloped nets decreased excitability. Ultimately, this impairment functional recruitment disrupts cortical excitation–inhibition with mice exhibiting spontaneous epileptic seizures. Our findings suggest developmental repurposed stabilize brain.

Язык: Английский

Процитировано

19

The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders DOI Creative Commons

Teresa H. Wen,

Devin K. Binder, Iryna M. Ethell

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2018, Номер 11

Опубликована: Авг. 3, 2018

Perineuronal nets (PNN) are extracellular matrix (ECM) assemblies that preferentially ensheath parvalbumin (PV) expressing interneurons. Converging evidence indicates PV cells and PNN impaired in a variety of neurological disorders. development maintenance is necessary for number processes within the CNS, including regulation GABAergic cell function, protection neurons from oxidative stress, closure developmental critical period plasticity windows. Understanding functions may be essential characterizing mechanisms altered cortical excitability observed neurodegenerative neurodevelopmental Indeed, abnormalities have been post-mortem brain tissues patients with schizophrenia Alzheimer's disease. There PNNs enhanced activity its key regulator metalloproteinase-9 (MMP-9) Fragile X Syndrome, common genetic cause autism. MMP-9, protease cleaves ECM, differentially regulated these Despite this, few studies addressed interactions between expression, MMP-9 neuronal excitability. In this review, we highlight current CNS disorders associated network function levels, emphasizing need future work targeting pathophysiology therapeutic treatment

Язык: Английский

Процитировано

149

Perineuronal nets in brain physiology and disease DOI Creative Commons

Damien Testa,

Alain Prochiantz, Ariel A. Di Nardo

и другие.

Seminars in Cell and Developmental Biology, Год журнала: 2018, Номер 89, С. 125 - 135

Опубликована: Окт. 9, 2018

Язык: Английский

Процитировано

127