Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

Science, Год журнала: 2019, Номер 366(6465), С. 628 - 631

Опубликована: Окт. 31, 2019

Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related not known. We used accelerated neuroimaging measure physiological dynamics human discovered a coherent pattern oscillating electrophysiological, hemodynamic, CSF that appears during non-rapid eye movement sleep. Neural slow followed by hemodynamic oscillations, which turn coupled flow. These results demonstrate sleeping exhibits flow on macroscopic scale, interlinked with rhythms.

Язык: Английский

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Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways

Nature Reviews Neurology, Год журнала: 2019, Номер 16(1), С. 30 - 42

Опубликована: Дек. 11, 2019

Язык: Английский

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Hierarchical Heterogeneity across Human Cortex Shapes Large-Scale Neural Dynamics

Neuron, Год журнала: 2019, Номер 101(6), С. 1181 - 1194.e13

Опубликована: Фев. 10, 2019

The large-scale organization of dynamical neural activity across cortex emerges through long-range interactions among local circuits. We hypothesized that dynamics are also shaped by heterogeneity intrinsic properties cortical areas. One key axis along which microcircuit specialized relates to hierarchical levels organization. developed a circuit model human incorporates synaptic strengths, following inferred from magnetic resonance imaging (MRI)-derived T1- T2-weighted (T1w/T2w) mapping and fit the using multimodal neuroimaging data. found incorporating substantially improves functional MRI (fMRI)-measured resting-state connectivity captures sensory-association multiple fMRI features. predicts hierarchically organized higher-frequency spectral power, we tested with magnetoencephalography. These findings suggest circuit-level mechanisms linking spatiotemporal analysis highlight importance their specialization on dynamics.

Язык: Английский

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Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain

Neuron, Год журнала: 2019, Номер 105(3), С. 549 - 561.e5

Опубликована: Дек. 3, 2019

Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important process in brain health and diseases such as Alzheimer's disease (AD) cerebral amyloid angiopathy (CAA). However, the major driving force for clearance remains largely unknown. Here we used vivo two-photon microscopy awake head-fixed mice assess role spontaneous vasomotion paravascular clearance. Vasomotion correlated with fluorescent dextran from interstitial fluid. Increasing amplitude by means visually evoked vascular responses resulted increased rates visual cortex mice. Evoked reactivity was impaired CAA, which corresponded slower rates. Our findings suggest that low-frequency arteriolar oscillations drive solutes. Targeting naturally occurring patients CAA or AD may a promising early therapeutic option prevention Aβ accumulation brain.

Язык: Английский

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Fluid transport in the brain

Physiological Reviews, Год журнала: 2021, Номер 102(2), С. 1025 - 1151

Опубликована: Май 5, 2021

The brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the is geared fully toward processing information and behaving, while homeostatic functions predominate during sleep. blood-brain barrier establishes stable environment that optimal for neuronal function, yet imposes physiological problem; transcapillary filtration forms extracellular fluid in other organs reduced to minimum brain. Consequently, depends on special [the cerebrospinal (CSF)] flushed into along perivascular spaces created by astrocytic vascular endfeet. We describe this pathway, coined term glymphatic system, based dependency endfeet their adluminal expression of aquaporin-4 water channels facing CSF-filled spaces. Glymphatic clearance potentially harmful metabolic or protein waste products, such as amyloid-β, primarily active sleep, when drivers, cardiac cycle, respiration, slow vasomotion, together efficiently propel CSF inflow periarterial brain's space contains an abundance proteoglycans hyaluronan, which provide low-resistance hydraulic conduit rapidly can expand shrink sleep-wake cycle. system brain, meets requisites maintain homeostasis similar peripheral organs, considering blood-brain-barrier paths formation egress CSF.

Язык: Английский

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Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Ноя. 20, 2019

Abstract Extensive in vivo imaging studies investigate the hippocampal neural network function, mainly focusing on dorsal CA1 region given its optical accessibility. Multi-modality fMRI with simultaneous electrophysiological recording reveal broad cortical correlation patterns, but detailed spatial functional map remains lacking limited resolution. In particular, hemodynamic responses linked to specific activity are unclear at single-vessel level across vasculature, which hinders deciphering of malfunction animal models and translation critical neurovascular coupling (NVC) patterns for human fMRI. We simultaneously acquired optogenetically-driven neuronal Ca 2+ signals blood-oxygen-level-dependent (BOLD) cerebral-blood-volume (CBV)-fMRI from individual venules arterioles. Distinct spatiotemporal were correlated optogenetically evoked spreading depression-like calcium events. The event-related modeling revealed significantly reduced NVC efficiency upon (SDL) events, providing a direct measure function various states.

Язык: Английский

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Weak correlations between hemodynamic signals and ongoing neural activity during the resting state

Nature Neuroscience, Год журнала: 2017, Номер 20(12), С. 1761 - 1769

Опубликована: Ноя. 3, 2017

Язык: Английский

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Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans

Trends in Neurosciences, Год журнала: 2020, Номер 44(3), С. 227 - 240

Опубликована: Ноя. 24, 2020

The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in modern neuroscience. PFC has a Janus-faced nature: it enables sophisticated cognitive and social abilities that reach their maximum expression humans, yet underlies some devastating symptoms psychiatric disorders. Accordingly, appropriate development is crucial for many high-order dysregulation this process been linked to various neuropsychiatric diseases. Reviewing recent advances field, with primary focus on rodents we highlight why, despite differences across species, cross-species approach fruitful strategy understanding development. We briefly review developmental contribution molecules extensively discuss how electrical activity controls early maturation wiring areas, as well emergence refinement input-output circuitry involved processing. Finally, mechanisms dysfunction relevance

Язык: Английский

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Interface, interaction, and intelligence in generalized brain–computer interfaces

Trends in Cognitive Sciences, Год журнала: 2021, Номер 25(8), С. 671 - 684

Опубликована: Июнь 8, 2021

Язык: Английский

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Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Янв. 7, 2020

Abstract A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that N-methyl-d-aspartate receptor (NMDAR) antagonists such as act preferentially on GABAergic neurons. However, cortical interneurons are heterogeneous. particular, somatostatin-expressing (SST) selectively inhibit dendrites regulate synaptic inputs, yet their response to systemic NMDAR antagonism is unknown. Here, we report acutely suppresses activity SST in medial cortex awake mouse. The deficient dendritic inhibition leads greater synaptically evoked calcium transients apical spines pyramidal By manipulating signaling via GluN2B knockdown, show ketamine’s actions inhibitory mechanism has ramifications for frontal cortex-dependent behaviors cortico-cortical connectivity. Collectively, these results demonstrate elevated levels important local-circuit alterations driven by administration ketamine.

Язык: Английский

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