Cannabinoids and the expanded endocannabinoid system in neurological disorders

Nature Reviews Neurology, Год журнала: 2019, Номер 16(1), С. 9 - 29

Опубликована: Дек. 12, 2019

Язык: Английский

---

Astrocyte function from information processing to cognition and cognitive impairment

Nature Neuroscience, Год журнала: 2019, Номер 22(2), С. 154 - 166

Опубликована: Янв. 21, 2019

Язык: Английский

---

Diversity and Specificity of Astrocyte–neuron Communication

Neuroscience, Год журнала: 2018, Номер 396, С. 73 - 78

Опубликована: Ноя. 17, 2018

Язык: Английский

---

Behaviorally consequential astrocytic regulation of neural circuits

Neuron, Год журнала: 2020, Номер 109(4), С. 576 - 596

Опубликована: Дек. 31, 2020

Язык: Английский

---

Glucose metabolism links astroglial mitochondria to cannabinoid effects

Nature, Год журнала: 2020, Номер 583(7817), С. 603 - 608

Опубликована: Июль 8, 2020

Язык: Английский

---

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

Neuroscience, Год журнала: 2020, Номер 456, С. 71 - 84

Опубликована: Март 26, 2020

Язык: Английский

---

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Acta Neuropathologica Communications, Год журнала: 2018, Номер 6(1)

Опубликована: Окт. 15, 2018

Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions such as Alzheimer's disease. However, the specific role reactive astrocytes is still debated. This controversy may stem from fact that most strategies used to modulate astrocyte explore its contribution disease outcomes have only limited specificity. Moreover, now emerging heterogeneous cells all types not be controlled efficiently by strategies.Here, we cell type-specific approaches in vivo identified JAK2-STAT3 pathway, necessary sufficient for induction maintenance reactivity. Modulation this cascade viral gene transfer mouse several morphological molecular features Inhibition pathway models improved three key reducing amyloid deposition, improving spatial learning restoring synaptic deficits.In conclusion, operates a master regulator vivo. Its inhibition offers new therapeutic opportunities

Язык: Английский

---

Structural basis of astrocytic Ca2+ signals at tripartite synapses

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Апрель 20, 2020

Astrocytic Ca2+ signals can be fast and local, supporting the idea that astrocytes have ability to regulate single synapses. However, anatomical basis of such specific signaling remains unclear, owing difficulties in resolving spongiform domain where most tripartite synapses are located. Using 3D-STED microscopy living organotypic brain slices, we imaged observed a reticular meshwork nodes shafts often formed loop-like structures. These features were also acute hippocampal slices barrel cortex vivo. The majority dendritic spines contacted by their sizes correlated. FRAP experiments imaging showed biochemical compartments microdomains. Mapping astrocytic onto STED images they associated with individual Here, report on nanoscale organization astrocytes, identifying as functional component may enable synapse-specific communication between neurons astrocytes.

Язык: Английский

---

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Янв. 24, 2020

Abstract Astrocytes may function as mediators of the impact noradrenaline on neuronal function. Activation glial α1-adrenergic receptors triggers rapid astrocytic Ca 2+ elevation and facilitates synaptic plasticity, while activation β-adrenergic elevates cAMP levels modulates memory consolidation. However, dynamics these processes in behaving mice remain unexplored, do interactions between distinct second messenger pathways. Here we simultaneously monitored demonstrate that messengers are regulated a temporally manner. In mice, found an abrupt facial air puff triggered transient increases release large cytosolic elevations, changes were not detectable. By contrast, repeated aversive stimuli lead to prolonged periods vigilance accompanied by robust noradrenergic axonal activity gradual sustained increases. Our findings suggest signaling pathways can integrate during states mediate functions supporting memory.

Язык: Английский

---

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Nature Neuroscience, Год журнала: 2021, Номер 24(4), С. 529 - 541

Опубликована: Фев. 15, 2021

Язык: Английский

---