Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse DOI Creative Commons

Julie Polanco,

Fredy Reyes-Vigil,

Sarah D. Weisberg

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2021, Номер 14

Опубликована: Март 23, 2021

Type I and type II classical cadherins comprise a family of cell adhesion molecules that regulate sorting tissue separation by forming specific homo heterophilic bonds. Factors affect cadherin-mediated cell-cell include cadherin binding affinity expression level. This study examines the pattern ( Cdh1 , Cdh2 Cdh3 Cdh4 ), Cdh6 Cdh7 Cdh8 Cdh9 Cdh10 Cdh11 Cdh12 Cdh18 Cdh20 Cdh24 atypical 13 Cdh13 ) during distinct morphogenetic events in developing mouse central nervous system from embryonic day 11.5 to postnatal 56. Cadherin mRNA levels obtained situ hybridization experiments carried out at Allen Institute for Brain Science https://alleninstitute.org/ were retrieved Developing Mouse Atlas. is most abundantly expressed throughout development, while are low levels. show dynamic varies between neuroanatomical structures developmental ages. Atypical correlates with abundancy localization. Analyses relative estimated their level substantial differences adhesive properties regions neural tube associated segmentation along anterior–posterior axis. Differences also observed brain nuclei subpallium (basal ganglia), suggesting differential contributes segregation neuronal pools. In adult cerebral cortex, abundant intermediate layers, shows gradated deeper layer 6 superficial 1, more layers. Person’s correlation analyses patterns areas layers cortex significant correlations certain cortical basal ganglia. The wide range including organization neurons into nuclei, formation circuits.

Язык: Английский

Subtype-specific survival and regeneration of retinal ganglion cells in response to injury DOI Creative Commons

Mary L. Tapia,

Gabriel Nascimento‐dos‐Santos, Kevin K. Park

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10

Опубликована: Авг. 12, 2022

Retinal ganglion cells (RGCs) are a heterogeneous population of neurons that function synchronously to convey visual information through the optic nerve retinorecipient target areas in brain. Injury or disease results RGC degeneration and loss function, as few RGCs survive, even fewer can be provoked regenerate their axons. Despite causative insults being broadly shared, regeneration studies demonstrate types exhibit differential resilience injury undergo selective survival While most early have identified these based morphological physiological characteristics, recent advances transgenic gene sequencing technologies further enabled type identification on unique molecular features. In this review, we provide an overview well characterized identify those shown preferentially survive various models. Furthermore, discuss cellular characteristics both resilient susceptible including combinatorial expression different markers specific populations. Lastly, potential mechanisms genes found selectively expressed by may contribute reparative capacity. Together, describe lay important groundwork for identifying factors promote neural help advance development targeted therapy treatment neurodegenerative diseases general.

Язык: Английский

Процитировано

24
Genetically defined neuron types underlying visuomotor transformation in the superior colliculus DOI
Jianhua Cang, Chen Chen,

Chuiwen Li

и другие.

Nature reviews. Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

6
Retinal ganglion cell interactions shape the developing mammalian visual system DOI Creative Commons
Shane P. D’Souza, Richard A. Lang

Development, Год журнала: 2020, Номер 147(23)

Опубликована: Дек. 1, 2020

ABSTRACT Retinal ganglion cells (RGCs) serve as a crucial communication channel from the retina to brain. In adult, these receive input defined sets of presynaptic partners and communicate with postsynaptic brain regions convey features visual scene. However, in developing system, RGC interactions extend beyond their synaptic such that they guide development before onset vision. this Review, we summarize our current understanding how between RGCs environment influence cellular targeting, migration circuit maturation during system development. We describe roles subclasses shaping unique developmental responses within at central targets. Finally, highlight utility RNA sequencing genetic tools uncovering type-specific system.

Язык: Английский

Процитировано

38
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation DOI Creative Commons
Emily Ling-Lin Pai, Jin Chen, Siavash Fazel Darbandi

и другие.

eLife, Год журнала: 2020, Номер 9

Опубликована: Май 26, 2020

​Maf (c-Maf) and Mafb transcription factors (TFs) have compensatory roles in repressing somatostatin (SST+) interneuron (IN) production medial ganglionic eminence (MGE) secondary progenitors mice. Maf conditional deletion (cDKO) decreases the survival of MGE-derived cortical interneurons (CINs) changes their physiological properties. Herein, we show that (1) Mef2c Snap25 are positively regulated by to drive IN morphological maturation; (2) promote expression which specifies parvalbumin (PV+) INs; (3) Elmo1, Igfbp4 candidate markers immature PV+ hippocampal INs (HIN). Furthermore, Maf/Mafb neonatal cDKOs decreased CINs increased HINs, express Pnoc, an HIN specific marker. Our findings not only elucidate key gene targets control development, but also identify for first time TFs differentially regulate CIN vs. production.

Язык: Английский

Процитировано

33
Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse DOI Creative Commons

Julie Polanco,

Fredy Reyes-Vigil,

Sarah D. Weisberg

и другие.

Frontiers in Molecular Neuroscience, Год журнала: 2021, Номер 14

Опубликована: Март 23, 2021

Type I and type II classical cadherins comprise a family of cell adhesion molecules that regulate sorting tissue separation by forming specific homo heterophilic bonds. Factors affect cadherin-mediated cell-cell include cadherin binding affinity expression level. This study examines the pattern ( Cdh1 , Cdh2 Cdh3 Cdh4 ), Cdh6 Cdh7 Cdh8 Cdh9 Cdh10 Cdh11 Cdh12 Cdh18 Cdh20 Cdh24 atypical 13 Cdh13 ) during distinct morphogenetic events in developing mouse central nervous system from embryonic day 11.5 to postnatal 56. Cadherin mRNA levels obtained situ hybridization experiments carried out at Allen Institute for Brain Science https://alleninstitute.org/ were retrieved Developing Mouse Atlas. is most abundantly expressed throughout development, while are low levels. show dynamic varies between neuroanatomical structures developmental ages. Atypical correlates with abundancy localization. Analyses relative estimated their level substantial differences adhesive properties regions neural tube associated segmentation along anterior–posterior axis. Differences also observed brain nuclei subpallium (basal ganglia), suggesting differential contributes segregation neuronal pools. In adult cerebral cortex, abundant intermediate layers, shows gradated deeper layer 6 superficial 1, more layers. Person’s correlation analyses patterns areas layers cortex significant correlations certain cortical basal ganglia. The wide range including organization neurons into nuclei, formation circuits.

Язык: Английский

Процитировано

30