Cell, Год журнала: 2021, Номер 184(7), С. 1740 - 1756.e16
Опубликована: Март 11, 2021
Язык: Английский
Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 1877 - 2013
Опубликована: Авг. 28, 2019
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric
Язык: Английский
Процитировано
3429
Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)
Опубликована: Апрель 23, 2022
Abstract The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, can be classified into gut, oral, respiratory, skin microbiota. microbial communities are symbiosis with host, contributing to homeostasis regulating immune function. However, dysbiosis lead dysregulation bodily functions including cardiovascular (CVDs), cancers, respiratory diseases, etc. In this review, we discuss current knowledge how links host or pathogenesis. We first summarize research healthy conditions, gut-brain axis, colonization resistance modulation. Then, highlight pathogenesis disease development progression, primarily associated community composition, modulation response, induction chronic inflammation. Finally, introduce clinical approaches that utilize for treatment, such as fecal transplantation.
Язык: Английский
Процитировано
1557
Nature Reviews Microbiology, Год журнала: 2020, Номер 19(4), С. 241 - 255
Опубликована: Окт. 22, 2020
Язык: Английский
Процитировано
1451
The Lancet Neurology, Год журнала: 2019, Номер 19(2), С. 179 - 194
Опубликована: Ноя. 18, 2019
Язык: Английский
Процитировано
977
Cell, Год журнала: 2019, Номер 177(6), С. 1600 - 1618.e17
Опубликована: Май 1, 2019
Язык: Английский
Процитировано
911
Gastroenterology, Год журнала: 2021, Номер 160(5), С. 1486 - 1501
Опубликована: Янв. 22, 2021
Язык: Английский
Процитировано
646
Nutrients, Год журнала: 2021, Номер 13(6), С. 2099 - 2099
Опубликована: Июнь 19, 2021
Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among metabolic, peripheral immune, central nervous systems via microbiota–gut–brain axis. However, it not well understood how microbiome neurons mutually interact or these interactions affect normal functioning cognition. We summarize mechanisms whereby regulate production, transportation, neurotransmitters. also discuss dysbiosis affects function, especially neurodegenerative diseases such as Alzheimer’s disease Parkinson’s disease.
Язык: Английский
Процитировано
530
Science, Год журнала: 2021, Номер 374(6571), С. 1087 - 1092
Опубликована: Ноя. 25, 2021
The brain and gastrointestinal tract are critical sensory organs responsible for detecting, relaying, integrating, responding to signals derived from the internal external environment. At interface of this function, immune cells in intestines consistently survey environmental factors, eliciting responses that inform on physiological state body. Recent research reveals cross-talk along gut-brain axis regulates inflammatory nociception, responses, homeostasis. Here, we discuss molecular cellular mechanisms involved signaling inflammation across axis. We further highlight interactions between gut inflammation-associated diseases.
Язык: Английский
Процитировано
478
Chemical Society Reviews, Год журнала: 2020, Номер 49(15), С. 5473 - 5509
Опубликована: Янв. 1, 2020
Amyloid diseases are global epidemics with profound health, social and economic implications yet remain without a cure. This dire situation calls for research into the origin pathological manifestations of amyloidosis to stimulate continued development new therapeutics. In basic science engineering, cross-β architecture has been constant thread underlying structural characteristics functional amyloids, realizing that amyloid structures can be both in nature fuelled innovations artificial whose use today ranges from water purification 3D printing. At conclusion half century since Eanes Glenner's seminal study amyloids humans, this review commemorates occasion by documenting major milestones date, perspectives biology, biophysics, medicine, microbiology, engineering nanotechnology. We also discuss challenges opportunities drive interdisciplinary field moving forward.
Язык: Английский
Процитировано
476
Neuron, Год журнала: 2019, Номер 101(6), С. 998 - 1002
Опубликована: Март 1, 2019
Язык: Английский
Процитировано
455