Cells,
Год журнала:
2019,
Номер
8(9), С. 1005 - 1005
Опубликована: Авг. 29, 2019
The
basal
ganglia
(BG)
are
a
collection
of
interconnected
subcortical
nuclei
that
participate
in
great
variety
functions,
ranging
from
motor
programming
and
execution
to
procedural
learning,
cognition,
emotions.
This
network
is
also
the
region
primarily
affected
by
degeneration
midbrain
dopaminergic
neurons
localized
substantia
nigra
pars
compacta
(SNc).
causes
cellular
synaptic
dysfunctions
BG
network,
which
responsible
for
appearance
symptoms
Parkinson’s
disease.
Dopamine
(DA)
modulation
consequences
its
loss
on
striatal
microcircuit
have
been
extensively
studied,
because
discrete
nature
DA
innervation
other
nuclei,
action
outside
striatum
has
considered
negligible.
However,
there
growing
body
evidence
supporting
functional
extrastriatal
both
excitability
transmission.
In
this
review,
relevance
normal
pathological
conditions
will
be
discussed.
Movement Disorders,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 12, 2024
Invasive
deep
brain
stimulation
(DBS)
has
been
shown
to
be
effective
in
treating
patients
with
Parkinson's
disease
(PD),
yet
its
clinical
use
is
limited
at
the
advanced
stage
of
disease.
Transcranial
temporal
interference
(tTIS)
may
a
novel
nonneurosurgical
and
safer
alternative,
therapeutic
potential
remains
unexplored.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Abstract
BTB
domain
and
CNC
homolog
1
(BACH1)
belongs
to
the
family
of
basic
leucine
zipper
proteins
is
expressed
in
most
mammalian
tissues.
It
can
regulate
its
own
expression
play
a
role
transcriptionally
activating
or
inhibiting
downstream
target
genes.
has
crucial
various
biological
processes,
such
as
oxidative
stress,
cell
cycle,
heme
homeostasis,
immune
regulation.
Recent
research
highlights
BACH1's
significant
regulatory
roles
series
conditions,
including
stem
pluripotency
maintenance
differentiation,
growth,
senescence,
apoptosis.
BACH1
closely
associated
with
cardiovascular
diseases
contributes
angiogenesis,
atherosclerosis,
restenosis,
pathological
cardiac
hypertrophy,
myocardial
infarction,
ischemia/reperfusion
(I/R)
injury.
promotes
tumor
proliferation
metastasis
by
altering
metabolism
epithelial‐mesenchymal
transition
phenotype.
Moreover,
appears
show
an
adverse
neurodegenerative
diseases,
gastrointestinal
disorders,
leukemia,
pulmonary
fibrosis,
skin
diseases.
Inhibiting
may
be
beneficial
for
treating
these
This
review
summarizes
mechanism
different
types
proposing
that
precise
targeted
intervention
provide
new
strategies
human
disease
prevention
treatment.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 19, 2025
Transcranial
ultrasound
stimulation
(TUS)
offers
precise,
non-invasive
neuromodulation,
though
its
impact
on
human
deep
brain
structures
remains
underexplored.
Here
we
examined
TUS-induced
changes
in
the
basal
ganglia
of
10
individuals
with
movement
disorders
(Parkinson's
disease
and
dystonia)
15
healthy
participants.
Local
field
potentials
were
recorded
using
(DBS)
leads
globus
pallidus
internus
(GPi).
Compared
to
sham,
theta
burst
TUS
(tbTUS)
increased
power
during
stimulation,
while
Hz
enhanced
beta
power,
effects
lasting
up
40
min.
In
participants,
a
stop-signal
task
assessed
tbTUS
GPi,
pulvinar
serving
as
an
active
sham.
GPi
prolonged
reaction
times,
indicating
impaired
response
inhibition,
whereas
had
no
effect.
These
findings
provide
direct
electrophysiological
evidence
target
engagement
specificity
structures,
suggesting
potential
noninvasive
DBS
strategy
for
neurological
psychiatric
disorders.
is
method
modulate
activity.
Using
recordings
from
implanted
electrodes,
showed
that
engages
internus,
neural
oscillations
behavior.
Cells,
Год журнала:
2019,
Номер
8(9), С. 1005 - 1005
Опубликована: Авг. 29, 2019
The
basal
ganglia
(BG)
are
a
collection
of
interconnected
subcortical
nuclei
that
participate
in
great
variety
functions,
ranging
from
motor
programming
and
execution
to
procedural
learning,
cognition,
emotions.
This
network
is
also
the
region
primarily
affected
by
degeneration
midbrain
dopaminergic
neurons
localized
substantia
nigra
pars
compacta
(SNc).
causes
cellular
synaptic
dysfunctions
BG
network,
which
responsible
for
appearance
symptoms
Parkinson’s
disease.
Dopamine
(DA)
modulation
consequences
its
loss
on
striatal
microcircuit
have
been
extensively
studied,
because
discrete
nature
DA
innervation
other
nuclei,
action
outside
striatum
has
considered
negligible.
However,
there
growing
body
evidence
supporting
functional
extrastriatal
both
excitability
transmission.
In
this
review,
relevance
normal
pathological
conditions
will
be
discussed.
