The Role of the Locus Coeruleus in Pain and Associated Stress-Related Disorders DOI Creative Commons
Irene Suárez‐Pereira, Meritxell Llorca-Torralba, Lidia Bravo

и другие.

Biological Psychiatry, Год журнала: 2021, Номер 91(9), С. 786 - 797

Опубликована: Дек. 16, 2021

The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in central nervous and involved intensively modulating pain stress-related disorders (e.g., major depressive disorder anxiety) their comorbidity. However, mechanisms involving LC that underlie these effects have not been fully elucidated, part owing to technical difficulties inherent exploring such a tiny nucleus. novel research tools are now available helped redefine system, moving away from traditional view as homogeneous structure exerts uniform influence on neural activity. Indeed, innovative techniques DREADDs (designer receptors exclusively activated by designer drugs) optogenetics demonstrated functional heterogeneity LC, magnetic resonance imaging applications combined with pupillometry opened way evaluate activity vivo. This review aims bring together data efferent LC-noradrenergic relation its comorbidity anxiodepressive disorders. Acute triggers robust stress response, producing spinal cord-mediated endogenous analgesia while promoting aversion, vigilance, threat detection through ascending efferents. this protective biological fails chronic pain, produces facilitation, anxiety, increased aversive memory, behavioral despair, acting at medulla, prefrontal cortex, amygdala levels. Thus, activation/deactivation specific projections contributes different outcomes shift acute pain.

Язык: Английский

Questions and controversies in the study of time-varying functional connectivity in resting fMRI DOI Creative Commons
Daniel J. Lurie, Daniel Kessler, Danielle S. Bassett

и другие.

Network Neuroscience, Год журнала: 2019, Номер 4(1), С. 30 - 69

Опубликована: Дек. 16, 2019

The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge the spatiotemporal organization these interactions critical for establishing solid understanding brain's functional architecture and relationship between neural dynamics cognition in health disease. possibility studying through careful analysis neuroimaging data has catalyzed substantial interest methods that estimate time-resolved fluctuations connectivity (often referred to as "dynamic" or time-varying connectivity; TVFC). At same time, debates have emerged regarding application TVFC analyses resting fMRI data, about statistical validity, physiological origins, cognitive behavioral relevance TVFC. These other unresolved issues complicate interpretation findings limit insights can be gained from this promising new research area. This article brings together scientists with variety perspectives on review current literature light issues. We introduce core concepts, define key terms, summarize controversies open questions, present forward-looking perspective how rigorously productively applied investigate wide range questions systems neuroscience.

Язык: Английский

Процитировано

552
Locus coeruleus: a new look at the blue spot DOI
Gina R. Poe,

Stephen L. Foote,

O Eschenko

и другие.

Nature reviews. Neuroscience, Год журнала: 2020, Номер 21(11), С. 644 - 659

Опубликована: Сен. 17, 2020

Язык: Английский

Процитировано

539
Redefining Noradrenergic Neuromodulation of Behavior: Impacts of a Modular Locus Coeruleus Architecture DOI Creative Commons

Dan J. Chandler,

Patricia Jensen, Jordan G. McCall

и другие.

Journal of Neuroscience, Год журнала: 2019, Номер 39(42), С. 8239 - 8249

Опубликована: Окт. 16, 2019

The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus that prominent component of disparate theories brain function due to its broad noradrenergic projections throughout the CNS. As diffuse system, noradrenaline affects learning decision making, control sleep wakefulness, sensory salience including pain, physiology correlated forebrain activity (ensembles networks) hemodynamic responses. However, our understanding LC undergoing dramatic shift application state-of-the-art methods reveal many modules provide targeted neuromodulation. Here, we review evidence supporting modular based on multiple levels observation (developmental, genetic, molecular, anatomical, neurophysiological). We suggest concept as and, alongside it, role in diverse must be reconsidered.

Язык: Английский

Процитировано

194
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics DOI
James M. Shine, Eli J. Müller, Brandon R. Munn

и другие.

Nature Neuroscience, Год журнала: 2021, Номер 24(6), С. 765 - 776

Опубликована: Май 6, 2021

Язык: Английский

Процитировано

193
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline DOI
Heidi I.L. Jacobs, J. Alex Becker, Kenneth K. Kwong

и другие.

Science Translational Medicine, Год журнала: 2021, Номер 13(612)

Опубликована: Сен. 22, 2021

In vivo and autopsy evidence supports locus coeruleus MRI measures as proxy of initial TAU deposition amyloid-related memory decline.

Язык: Английский

Процитировано

177
The role of the locus coeruleus in the generation of pathological anxiety DOI Creative Commons
Laurel Morris, Jordan G. McCall, Dennis S. Charney

и другие.

Brain and Neuroscience Advances, Год журнала: 2020, Номер 4, С. 239821282093032 - 239821282093032

Опубликована: Янв. 1, 2020

This review aims to synthesise a large pre-clinical and clinical literature related hypothesised role of the locus coeruleus norepinephrine system in responses acute chronic threat, as well emergence pathological anxiety. The has widespread projections throughout central nervous system, which act globally modulate arousal states adaptive behavior, crucially positioned play significant modulating both ascending visceral descending cortical neurocognitive information. In response threat or stressor, coeruleus–norepinephrine modulates arousal, alerting orienting functions can have powerful effect on regulation multiple memory systems. Chronic stress leads amplification reactivity subsequent stressors, is coupled with anxiety-like behaviors rodents. While direct vivo evidence for dysfunction humans anxiety remains limited, recent advances high-resolution 7-T magnetic resonance imaging computational modeling approaches are starting provide new insights into characteristics.

Язык: Английский

Процитировано

166
Neuromodulation in circuits of aversive emotional learning DOI
Ekaterina Likhtik, Joshua P. Johansen

Nature Neuroscience, Год журнала: 2019, Номер 22(10), С. 1586 - 1597

Опубликована: Сен. 24, 2019

Язык: Английский

Процитировано

158
The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives DOI Creative Commons
Jennifer A. Ross, Elisabeth J. Van Bockstaele

Frontiers in Psychiatry, Год журнала: 2021, Номер 11

Опубликована: Янв. 27, 2021

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction, and inattention one side, wakeful state in the middle, hypervigilance, panic, psychosis other side. However, historically, concepts of arousal stress have been challenging to define as measurable experimental variables. Divergent efforts study these subjects given rise several disciplines, including neurobiology, neuroendocrinology, neuroscience. We discuss technological advancements that chronologically led our current understanding system, focusing multifaceted nucleus locus coeruleus. share contemporary perspective hypotheses others context capabilities future developments will required move forward this area research.

Язык: Английский

Процитировано

146
Noradrenergic circuit control of non-REM sleep substates DOI Creative Commons
Alejandro Osorio-Forero, Romain Cardis, Gil Vantomme

и другие.

Current Biology, Год журнала: 2021, Номер 31(22), С. 5009 - 5023.e7

Опубликована: Окт. 14, 2021

To understand what makes sleep vulnerable in disease, it is useful to look at how wake-promoting mechanisms affect healthy sleep. Wake-promoting neuronal activity inhibited during non-rapid-eye-movement (NREMS). However, sensory vigilance persists NREMS animals and humans, suggesting that wake promotion could remain functional. Here, we demonstrate consolidated mouse a brain state with recurrent fluctuations of the neurotransmitter noradrenaline on ∼50-s timescale thalamus. These occurred around mean levels greater than ones quiet wakefulness, while (NA) declined steeply REMS. They coincided clustering spindle rhythms forebrain heart-rate variations, both which are correlates arousability. We addressed origins these by using closed-loop optogenetic locus coeruleus (LC) activation or inhibition timed moments low high NREMS. suppress, lock, entrain sleep-spindle fore- hindbrain-projecting LC neurons show coordinated infraslow variations natural Noradrenergic modulation thalamic, but not cortical, circuits was required for involved NA release into primary reticular thalamic nuclei activated α1- β-adrenergic receptors cause slowly decaying membrane depolarizations. signaling constitutes vigilance-promoting mechanism renders mammalian disruption close-to-minute through sustaining thalamocortical autonomic arousability.Video abstracthttps://www.cell.com/cms/asset/ab9ec3b8-a3f1-470e-8a9c-a2d6ebebc742/mmc3.mp4Loading ...(mp4, 35.34 MB) Download video

Язык: Английский

Процитировано

141
The role of the salience network in cognitive and affective deficits DOI Creative Commons
J. Schimmelpfennig,

Jan Topczewski,

Wojciech Kossut Zajkowski

и другие.

Frontiers in Human Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Март 20, 2023

Analysis and interpretation of studies on cognitive affective dysregulation often draw upon the network paradigm, especially Triple Network Model, which consists default mode (DMN), frontoparietal (FPN), salience (SN). DMN activity is primarily dominant during leisure self-monitoring processes. The FPN peaks task involvement exertion. Meanwhile, SN serves as a dynamic “switch” between FPN, in line with demand. In domains, dysfunctions involving are connected to broad spectrum deficits maladaptive behavioral patterns variety clinical disorders, such depression, insomnia, narcissism, PTSD (in case hyperactivity), chronic pain, anxiety, high degrees neuroticism, schizophrenia, epilepsy, autism, neurodegenerative illnesses, bipolar disorder hypoactivity). We discuss neurological data from various research domains present an integrated perspective indicating that these conditions can be associated widespread disruption predictive coding at multiple hierarchical levels. delineate fundamental ideas brain paradigm contrast them conventional modular method first section this article. Following this, we outline interaction model key functional networks highlight recent coupling SN-related impairments.

Язык: Английский

Процитировано

126