Biological Psychiatry,
Год журнала:
2021,
Номер
91(9), С. 786 - 797
Опубликована: Дек. 16, 2021
The
locus
coeruleus
(LC)-noradrenergic
system
is
the
main
source
of
noradrenaline
in
central
nervous
and
involved
intensively
modulating
pain
stress-related
disorders
(e.g.,
major
depressive
disorder
anxiety)
their
comorbidity.
However,
mechanisms
involving
LC
that
underlie
these
effects
have
not
been
fully
elucidated,
part
owing
to
technical
difficulties
inherent
exploring
such
a
tiny
nucleus.
novel
research
tools
are
now
available
helped
redefine
system,
moving
away
from
traditional
view
as
homogeneous
structure
exerts
uniform
influence
on
neural
activity.
Indeed,
innovative
techniques
DREADDs
(designer
receptors
exclusively
activated
by
designer
drugs)
optogenetics
demonstrated
functional
heterogeneity
LC,
magnetic
resonance
imaging
applications
combined
with
pupillometry
opened
way
evaluate
activity
vivo.
This
review
aims
bring
together
data
efferent
LC-noradrenergic
relation
its
comorbidity
anxiodepressive
disorders.
Acute
triggers
robust
stress
response,
producing
spinal
cord-mediated
endogenous
analgesia
while
promoting
aversion,
vigilance,
threat
detection
through
ascending
efferents.
this
protective
biological
fails
chronic
pain,
produces
facilitation,
anxiety,
increased
aversive
memory,
behavioral
despair,
acting
at
medulla,
prefrontal
cortex,
amygdala
levels.
Thus,
activation/deactivation
specific
projections
contributes
different
outcomes
shift
acute
pain.
Network Neuroscience,
Год журнала:
2019,
Номер
4(1), С. 30 - 69
Опубликована: Дек. 16, 2019
The
brain
is
a
complex,
multiscale
dynamical
system
composed
of
many
interacting
regions.
Knowledge
the
spatiotemporal
organization
these
interactions
critical
for
establishing
solid
understanding
brain's
functional
architecture
and
relationship
between
neural
dynamics
cognition
in
health
disease.
possibility
studying
through
careful
analysis
neuroimaging
data
has
catalyzed
substantial
interest
methods
that
estimate
time-resolved
fluctuations
connectivity
(often
referred
to
as
"dynamic"
or
time-varying
connectivity;
TVFC).
At
same
time,
debates
have
emerged
regarding
application
TVFC
analyses
resting
fMRI
data,
about
statistical
validity,
physiological
origins,
cognitive
behavioral
relevance
TVFC.
These
other
unresolved
issues
complicate
interpretation
findings
limit
insights
can
be
gained
from
this
promising
new
research
area.
This
article
brings
together
scientists
with
variety
perspectives
on
review
current
literature
light
issues.
We
introduce
core
concepts,
define
key
terms,
summarize
controversies
open
questions,
present
forward-looking
perspective
how
rigorously
productively
applied
investigate
wide
range
questions
systems
neuroscience.
Journal of Neuroscience,
Год журнала:
2019,
Номер
39(42), С. 8239 - 8249
Опубликована: Окт. 16, 2019
The
locus
coeruleus
(LC)
is
a
seemingly
singular
and
compact
neuromodulatory
nucleus
that
prominent
component
of
disparate
theories
brain
function
due
to
its
broad
noradrenergic
projections
throughout
the
CNS.
As
diffuse
system,
noradrenaline
affects
learning
decision
making,
control
sleep
wakefulness,
sensory
salience
including
pain,
physiology
correlated
forebrain
activity
(ensembles
networks)
hemodynamic
responses.
However,
our
understanding
LC
undergoing
dramatic
shift
application
state-of-the-art
methods
reveal
many
modules
provide
targeted
neuromodulation.
Here,
we
review
evidence
supporting
modular
based
on
multiple
levels
observation
(developmental,
genetic,
molecular,
anatomical,
neurophysiological).
We
suggest
concept
as
and,
alongside
it,
role
in
diverse
must
be
reconsidered.
Brain and Neuroscience Advances,
Год журнала:
2020,
Номер
4, С. 239821282093032 - 239821282093032
Опубликована: Янв. 1, 2020
This
review
aims
to
synthesise
a
large
pre-clinical
and
clinical
literature
related
hypothesised
role
of
the
locus
coeruleus
norepinephrine
system
in
responses
acute
chronic
threat,
as
well
emergence
pathological
anxiety.
The
has
widespread
projections
throughout
central
nervous
system,
which
act
globally
modulate
arousal
states
adaptive
behavior,
crucially
positioned
play
significant
modulating
both
ascending
visceral
descending
cortical
neurocognitive
information.
In
response
threat
or
stressor,
coeruleus–norepinephrine
modulates
arousal,
alerting
orienting
functions
can
have
powerful
effect
on
regulation
multiple
memory
systems.
Chronic
stress
leads
amplification
reactivity
subsequent
stressors,
is
coupled
with
anxiety-like
behaviors
rodents.
While
direct
vivo
evidence
for
dysfunction
humans
anxiety
remains
limited,
recent
advances
high-resolution
7-T
magnetic
resonance
imaging
computational
modeling
approaches
are
starting
provide
new
insights
into
characteristics.
Frontiers in Psychiatry,
Год журнала:
2021,
Номер
11
Опубликована: Янв. 27, 2021
Arousal
may
be
understood
on
a
spectrum,
with
excessive
sleepiness,
cognitive
dysfunction,
and
inattention
one
side,
wakeful
state
in
the
middle,
hypervigilance,
panic,
psychosis
other
side.
However,
historically,
concepts
of
arousal
stress
have
been
challenging
to
define
as
measurable
experimental
variables.
Divergent
efforts
study
these
subjects
given
rise
several
disciplines,
including
neurobiology,
neuroendocrinology,
neuroscience.
We
discuss
technological
advancements
that
chronologically
led
our
current
understanding
system,
focusing
multifaceted
nucleus
locus
coeruleus.
share
contemporary
perspective
hypotheses
others
context
capabilities
future
developments
will
required
move
forward
this
area
research.
Current Biology,
Год журнала:
2021,
Номер
31(22), С. 5009 - 5023.e7
Опубликована: Окт. 14, 2021
To
understand
what
makes
sleep
vulnerable
in
disease,
it
is
useful
to
look
at
how
wake-promoting
mechanisms
affect
healthy
sleep.
Wake-promoting
neuronal
activity
inhibited
during
non-rapid-eye-movement
(NREMS).
However,
sensory
vigilance
persists
NREMS
animals
and
humans,
suggesting
that
wake
promotion
could
remain
functional.
Here,
we
demonstrate
consolidated
mouse
a
brain
state
with
recurrent
fluctuations
of
the
neurotransmitter
noradrenaline
on
∼50-s
timescale
thalamus.
These
occurred
around
mean
levels
greater
than
ones
quiet
wakefulness,
while
(NA)
declined
steeply
REMS.
They
coincided
clustering
spindle
rhythms
forebrain
heart-rate
variations,
both
which
are
correlates
arousability.
We
addressed
origins
these
by
using
closed-loop
optogenetic
locus
coeruleus
(LC)
activation
or
inhibition
timed
moments
low
high
NREMS.
suppress,
lock,
entrain
sleep-spindle
fore-
hindbrain-projecting
LC
neurons
show
coordinated
infraslow
variations
natural
Noradrenergic
modulation
thalamic,
but
not
cortical,
circuits
was
required
for
involved
NA
release
into
primary
reticular
thalamic
nuclei
activated
α1-
β-adrenergic
receptors
cause
slowly
decaying
membrane
depolarizations.
signaling
constitutes
vigilance-promoting
mechanism
renders
mammalian
disruption
close-to-minute
through
sustaining
thalamocortical
autonomic
arousability.Video
abstracthttps://www.cell.com/cms/asset/ab9ec3b8-a3f1-470e-8a9c-a2d6ebebc742/mmc3.mp4Loading
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Frontiers in Human Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Март 20, 2023
Analysis
and
interpretation
of
studies
on
cognitive
affective
dysregulation
often
draw
upon
the
network
paradigm,
especially
Triple
Network
Model,
which
consists
default
mode
(DMN),
frontoparietal
(FPN),
salience
(SN).
DMN
activity
is
primarily
dominant
during
leisure
self-monitoring
processes.
The
FPN
peaks
task
involvement
exertion.
Meanwhile,
SN
serves
as
a
dynamic
“switch”
between
FPN,
in
line
with
demand.
In
domains,
dysfunctions
involving
are
connected
to
broad
spectrum
deficits
maladaptive
behavioral
patterns
variety
clinical
disorders,
such
depression,
insomnia,
narcissism,
PTSD
(in
case
hyperactivity),
chronic
pain,
anxiety,
high
degrees
neuroticism,
schizophrenia,
epilepsy,
autism,
neurodegenerative
illnesses,
bipolar
disorder
hypoactivity).
We
discuss
neurological
data
from
various
research
domains
present
an
integrated
perspective
indicating
that
these
conditions
can
be
associated
widespread
disruption
predictive
coding
at
multiple
hierarchical
levels.
delineate
fundamental
ideas
brain
paradigm
contrast
them
conventional
modular
method
first
section
this
article.
Following
this,
we
outline
interaction
model
key
functional
networks
highlight
recent
coupling
SN-related
impairments.