Ultra-slow Oscillations in fMRI and Resting-State Connectivity: Neuronal and Vascular Contributions and Technical Confounds

Neuron, Год журнала: 2020, Номер 107(5), С. 782 - 804

Опубликована: Авг. 12, 2020

Язык: Английский

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Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains

eLife, Год журнала: 2020, Номер 9

Опубликована: Июнь 16, 2020

Decisions are often made by accumulating ambiguous evidence over time. The brain’s arousal systems activated during such decisions. In previous work in humans, we found that evoked responses of decisions reported rapid dilations the pupil and track a suppression biases accumulation decision-relevant (de Gee et al., 2017). Here, show this arousal-related decision bias acts on both conservative liberal biases, generalizes from humans to mice, perceptual memory-based challenging sound-detection tasks, impact spontaneous or experimentally induced choice was reduced under high phasic arousal. Similar occurred when drawn memory. All these behavioral effects were explained biases. Our results point general principle interplay between decision-making.

Язык: Английский

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Arousal-induced cortical activity triggers lactate release from astrocytes

Nature Metabolism, Год журнала: 2020, Номер 2(2), С. 179 - 191

Опубликована: Фев. 17, 2020

Язык: Английский

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What have we really learned from functional connectivity in clinical populations?

NeuroImage, Год журнала: 2021, Номер 242, С. 118466 - 118466

Опубликована: Авг. 10, 2021

Functional connectivity (FC), or the statistical interdependence of blood-oxygen dependent level (BOLD) signals between brain regions using fMRI, has emerged as a widely used tool for probing functional abnormalities in clinical populations due to promise approach across conceptual, technical, and practical levels. With an already vast steadily accumulating neuroimaging literature on neurodevelopmental, psychiatric, neurological diseases disorders which FC is primary measure, we aim here provide high-level synthesis major concepts that have arisen from findings manner cuts different conditions sheds light overarching principles. We highlight allowed us discover ubiquity intrinsic networks virtually all brains clarify typical patterns neurodevelopment over lifespan. This understanding maturation with age provided important benchmarks against evaluate divergent early life degeneration late life. turn led insight many are associated complex, distributed, network-level changes brain, opposed solely focal abnormalities. further emphasize role studies played supporting dimensional studying transdiagnostic symptoms enhancing multimodal characterization prediction trajectory symptom progression conditions. unprecedented opportunity offered by probe where function could not be easily studied otherwise, such consciousness. Lastly, suggest high priority areas future research acknowledge critical barriers use methods, particularly those related artifact removal, data denoising feasibility contexts.

Язык: Английский

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The Role of the Locus Coeruleus in Pain and Associated Stress-Related Disorders

Biological Psychiatry, Год журнала: 2021, Номер 91(9), С. 786 - 797

Опубликована: Дек. 16, 2021

The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in central nervous and involved intensively modulating pain stress-related disorders (e.g., major depressive disorder anxiety) their comorbidity. However, mechanisms involving LC that underlie these effects have not been fully elucidated, part owing to technical difficulties inherent exploring such a tiny nucleus. novel research tools are now available helped redefine system, moving away from traditional view as homogeneous structure exerts uniform influence on neural activity. Indeed, innovative techniques DREADDs (designer receptors exclusively activated by designer drugs) optogenetics demonstrated functional heterogeneity LC, magnetic resonance imaging applications combined with pupillometry opened way evaluate activity vivo. This review aims bring together data efferent LC-noradrenergic relation its comorbidity anxiodepressive disorders. Acute triggers robust stress response, producing spinal cord-mediated endogenous analgesia while promoting aversion, vigilance, threat detection through ascending efferents. this protective biological fails chronic pain, produces facilitation, anxiety, increased aversive memory, behavioral despair, acting at medulla, prefrontal cortex, amygdala levels. Thus, activation/deactivation specific projections contributes different outcomes shift acute pain.

Язык: Английский

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