Somatostatin interneurons restrict cell recruitment to retinally driven spontaneous activity in the developing cortex DOI Creative Commons
Alexandra H. Leighton, Juliette E. Cheyne,

Gerrit J. Houwen

и другие.

Cell Reports, Год журнала: 2021, Номер 36(1), С. 109316 - 109316

Опубликована: Июль 1, 2021

During early development, before the eyes open, synaptic refinement of sensory networks depends on activity generated by developing neurons themselves. In mouse visual system, retinal cells spontaneously depolarize and recruit downstream to bursts activity, where number recruited determines resolution retinotopic refinement. Here we show that during second post-natal week in cortex, somatostatin (SST)-expressing interneurons control recruitment retinally driven spontaneous activity. Suppressing SST increases cell participation allows events spread farther along cortex. same developmental period, a type high-participation, retina-independent event occurs. these events, receive such large excitatory charge inhibition is overwhelmed parts cortex participate each burst. These results reveal role restricting which may contribute retinotopy.

Язык: Английский

Innovations present in the primate interneuron repertoire DOI
Fenna M. Krienen, Melissa Goldman, Qiangge Zhang

и другие.

Nature, Год журнала: 2020, Номер 586(7828), С. 262 - 269

Опубликована: Сен. 30, 2020

Язык: Английский

Процитировано

313

Transient cortical circuits match spontaneous and sensory-driven activity during development DOI
Zoltán Molnár, Heiko J. Luhmann, Patrick O. Kanold

и другие.

Science, Год журнала: 2020, Номер 370(6514)

Опубликована: Окт. 16, 2020

At the earliest developmental stages, spontaneous activity synchronizes local and large-scale cortical networks. These networks form functional template for establishment of global thalamocortical architecture. The connections are established autonomously. However, from sensory periphery reshapes these circuits as soon afferents reach cortex. early-generated, largely transient neurons subplate play a key role in integrating sensory-driven activity. Early pathological conditions-such hypoxia, inflammation, or exposure to pharmacological compounds-alter patterns, which subsequently induce disturbances network This dysfunction may lead miswiring and, at later can be associated with neurological psychiatric conditions.

Язык: Английский

Процитировано

236

Prefrontal Cortex Development in Health and Disease: Lessons from Rodents and Humans DOI Creative Commons
Mattia Chini, Ileana L. Hanganu‐Opatz

Trends in Neurosciences, Год журнала: 2020, Номер 44(3), С. 227 - 240

Опубликована: Ноя. 24, 2020

The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in modern neuroscience. PFC has a Janus-faced nature: it enables sophisticated cognitive and social abilities that reach their maximum expression humans, yet underlies some devastating symptoms psychiatric disorders. Accordingly, appropriate development is crucial for many high-order dysregulation this process been linked to various neuropsychiatric diseases. Reviewing recent advances field, with primary focus on rodents we highlight why, despite differences across species, cross-species approach fruitful strategy understanding development. We briefly review developmental contribution molecules extensively discuss how electrical activity controls early maturation wiring areas, as well emergence refinement input-output circuitry involved processing. Finally, mechanisms dysfunction relevance

Язык: Английский

Процитировано

198

Cortical interneurons in autism DOI
Anis Contractor, Iryna M. Ethell, Carlos Portera‐Cailliau

и другие.

Nature Neuroscience, Год журнала: 2021, Номер 24(12), С. 1648 - 1659

Опубликована: Ноя. 29, 2021

Язык: Английский

Процитировано

119

An increase of inhibition drives the developmental decorrelation of neural activity DOI Creative Commons
Mattia Chini, Thomas Pfeffer, Ileana L. Hanganu‐Opatz

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Авг. 17, 2022

Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity, yet mechanisms underlying this process are poorly understood. The developmental transition has important functional consequences, as latter is thought allow for more efficient storage, retrieval, processing of information. Here, we show that, in mouse medial prefrontal cortex (mPFC), during first two postnatal weeks decorrelates following specific spatial patterns. This accompanied by concomitant tilting excitation-inhibition (E-I) ratio toward inhibition. Using optogenetic manipulations network modeling, that phenomena mechanistically linked, relative increase inhibition drives decorrelation activity. Accordingly, mice mimicking etiology neurodevelopmental disorders, subtle alterations E-I associated impairments correlational structure spike trains. Finally, capitalizing on EEG data newborn babies, an analogous takes place also human brain. Thus, changes control (de)correlation and, these means, its imbalance might contribute pathogenesis disorders.

Язык: Английский

Процитировано

119

Neuronal ensembles: Building blocks of neural circuits DOI Creative Commons
Rafael Yuste, Rosa Cossart, Emre Yaksi

и другие.

Neuron, Год журнала: 2024, Номер 112(6), С. 875 - 892

Опубликована: Янв. 22, 2024

Язык: Английский

Процитировано

38

Somatostatin interneurons control the timing of developmental desynchronization in cortical networks DOI Creative Commons
Laura Mòdol, Monika Moissidis, Martijn Selten

и другие.

Neuron, Год журнала: 2024, Номер 112(12), С. 2015 - 2030.e5

Опубликована: Апрель 9, 2024

Synchronous neuronal activity is a hallmark of the developing brain. In mouse cerebral cortex, decorrelates during second week postnatal development, progressively acquiring characteristic sparse pattern underlying integration sensory information. The maturation inhibition seems critical for this process, but interneurons involved in crucial transition network cortex remain unknown. Using vivo longitudinal two-photon calcium imaging period that precedes change from highly synchronous to decorrelated activity, we identify somatostatin-expressing (SST+) as modulators switch mice. Modulation SST+ cells accelerates or delays decorrelation cortical process involves regulating parvalbumin-expressing (PV+) interneurons. critically link inputs with local circuits, controlling neural dynamics while modulating other into nascent circuits.

Язык: Английский

Процитировано

20

Shifting Developmental Trajectories During Critical Periods of Brain Formation DOI Creative Commons
Nathalie Dehorter, Isabel del Pino

Frontiers in Cellular Neuroscience, Год журнала: 2020, Номер 14

Опубликована: Сен. 10, 2020

Research on critical periods of brain development is greatly expanding our understanding the cellular and molecular mechanisms underlying epochs heightened plasticity driven by environmental influence. Novel studies have started to reveal that timely interventions during hold potential reorient abnormal developmental trajectories in animal models neurological neuropsychiatric disorders. In this review, we re-examine fundamental criteria characterize a period, highlighting recently discovered health disease. addition, touch upon technological improvements modelling human-derived neural networks vitro. These scientific advances associated with use manipulations immature represent promising new preclinical setting will allow future translatability into clinical applications for neurodevelopmental disorders such as intellectual disability, autism spectrum schizophrenia.

Язык: Английский

Процитировано

103

GABAergic interneurons excite neonatal hippocampus in vivo DOI Creative Commons
Yasunobu Murata, Matthew T. Colonnese

Science Advances, Год журнала: 2020, Номер 6(24)

Опубликована: Июнь 12, 2020

During development, the brain’s “inhibitory” neurons act in a diverse manner, exciting hippocampus but inhibiting sensory cortex.

Язык: Английский

Процитировано

99

RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury DOI Creative Commons

Sina Stern,

Brett J. Hilton, Emily R. Burnside

и другие.

Neuron, Год журнала: 2021, Номер 109(21), С. 3436 - 3455.e9

Опубликована: Сен. 10, 2021

An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how two aspects are interwoven. Genetic loss-of-function experiments determine that small GTPase RhoA relays signals to cytoskeleton by adapting mechanisms set place during neuronal polarization. In response inhibitors, restricts axon regeneration activating myosin II compact actin and, thereby, restrain microtubule protrusion. However, astrocytic injury-induced astrogliosis through independent of microtubules Yes-activated protein (YAP) signaling. Cell-type-specific deletion spinal-cord-injured mice shows activation prevents regeneration, whereas is beneficial for axons. These data demonstrate inhibitors regulate shed light on capacity reactive astrocytes be growth after CNS injury, reveal cell-specific targeting as a promising therapeutic avenue.

Язык: Английский

Процитировано

99