Flexible gating between subspaces in a neural network model of internally guided task switching DOI Creative Commons
Yue Liu, Xiao‐Jing Wang

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 1, 2024

Behavioral flexibility relies on the brain's ability to switch rapidly between multiple tasks, even when task rule is not explicitly cued but must be inferred through trial and error. The underlying neural circuit mechanism remains poorly understood. We investigated recurrent networks (RNNs) trained perform an analog of classic Wisconsin Card Sorting Test. consist two modules responsible for representation sensorimotor mapping, respectively, where each module comprised a with excitatory neurons three major types inhibitory neurons. found that by self-sustained persistent activity across trials, error monitoring gated mapping emerged from training. Systematic dissection RNNs revealed detailed consistent different hyperparameters. networks' dynamical trajectories rules resided in separate subspaces population activity; collapsed performance was reduced chance level dendrite-targeting somatostatin-expressing interneurons were silenced, illustrating how phenomenological description representational explained specific mechanism. flexible switching unclear. Here authors analyzed modular network models cell reveal uncued switching.

Язык: Английский

Two Distinct Types of Eye-Head Coupling in Freely Moving Mice DOI Creative Commons
Arne F. Meyer, John O’Keefe, Jasper Poort

и другие.

Current Biology, Год журнала: 2020, Номер 30(11), С. 2116 - 2130.e6

Опубликована: Май 14, 2020

Animals actively interact with their environment to gather sensory information. There is conflicting evidence about how mice use vision sample environment. During head restraint, make rapid eye movements coupled between the eyes, similar conjugate saccadic in humans. However, when are free move heads, more complex and often non-conjugate, eyes moving opposite directions. We combined tracking freely found both observations explained by two eye-head coupling types, associated vestibular mechanisms. The first type comprised non-conjugate movements, which compensate for tilt changes maintain a visual field relative horizontal ground plane. second of was yaw rotation produce "saccade fixate" gaze pattern. head-initiated saccades, moved together direction but during subsequent fixation rotation. This saccade fixate pattern humans who (with or without movement) rapidly shift relies on movements. Both couplings were maintained social interactions visually guided object tracking. Even head-restrained mice, invariably attempted motion. Our results reveal that combine highlight similarities differences

Язык: Английский

Процитировано

156
Movement-Related Signals in Sensory Areas: Roles in Natural Behavior DOI
Philip R. L. Parker,

Morgan A. Brown,

Matthew C. Smear

и другие.

Trends in Neurosciences, Год журнала: 2020, Номер 43(8), С. 581 - 595

Опубликована: Июнь 22, 2020

Язык: Английский

Процитировано

153
Rethinking retrosplenial cortex: Perspectives and predictions DOI Creative Commons
Andrew S. Alexander,

Ryan Place,

Michael J. Starrett

и другие.

Neuron, Год журнала: 2022, Номер 111(2), С. 150 - 175

Опубликована: Дек. 1, 2022

Язык: Английский

Процитировано

73
Widespread and Highly Correlated Somato-dendritic Activity in Cortical Layer 5 Neurons DOI Creative Commons

Lou Beaulieu-Laroche,

Enrique H. S. Toloza,

Norma J. Brown

и другие.

Neuron, Год журнала: 2019, Номер 103(2), С. 235 - 241.e4

Опубликована: Июнь 6, 2019

Язык: Английский

Процитировано

93
Systems Neuroscience of Natural Behaviors in Rodents DOI Creative Commons
Emily Jane Dennis, Ahmed El Hady, Angie Michaiel

и другие.

Journal of Neuroscience, Год журнала: 2020, Номер 41(5), С. 911 - 919

Опубликована: Дек. 18, 2020

Animals evolved in complex environments, producing a wide range of behaviors, including navigation, foraging, prey capture, and conspecific interactions, which vary over timescales ranging from milliseconds to days. Historically, these behaviors have been the focus study for ecology ethology, while systems neuroscience has largely focused on short timescale that can be repeated thousands times occur highly artificial environments. Thanks recent advances machine learning, miniaturization, computation, it is newly possible freely moving animals more natural conditions applying techniques: performing temporally specific perturbations, modeling behavioral strategies, recording large numbers neurons are moving. The authors this review group scientists with deep appreciation common aims neuroscience, ecology, ethology. We believe an extremely exciting time neuroscientist, as we opportunity grow field, embrace interdisciplinary, open, collaborative research provide new insights allow researchers link knowledge across disciplines, species, scales. Here discuss origins context our own work highlight how combining approaches fields provided fresh into research. hope facilitates some interactions alliances helps us all do even better science, together.

Язык: Английский

Процитировано

78
The Guide to Dendritic Spikes of the Mammalian Cortex In Vitro and In Vivo DOI Creative Commons
Matthew E. Larkum, Jiameng Wu, Sarah Duverdin

и другие.

Neuroscience, Год журнала: 2022, Номер 489, С. 15 - 33

Опубликована: Фев. 17, 2022

Half a century since their discovery by Llinás and colleagues, dendritic spikes have been observed in various neurons different brain regions, from the neocortex cerebellum to basal ganglia. Dendrites exhibit terrifically diverse but stereotypical repertoire of spikes, sometimes specific subregions dendrite. Despite prevalence, we only glimpse into role behaving animal. This article aims survey full range found excitatory inhibitory neurons, compare themin vivoversusin vitro, discuss new studies describing human cortex. We focus on neocortical hippocampal present roadmap identify understand broader single-cell computation.

Язык: Английский

Процитировано

70
Active dendrites enable strong but sparse inputs to determine orientation selectivity DOI Creative Commons
Lea Goetz, Arnd Roth, Michael Häusser

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2021, Номер 118(30)

Опубликована: Июль 23, 2021

Significance An active pyramidal cell model, constrained by physiological and anatomical data, was used to simulate dendritic integration in vivo. The model shows that small numbers of strong excitatory synapses can trigger Na + NMDA spikes. Moreover, only a few spikes are sufficient drive single output action potential. As consequence, as 1% the synaptic inputs neuron determine tuning somatic These results suggest help make sensory representations more efficient flexible: they require fewer connections sustain them, number need be changed encode different stimulus alter response properties neuron.

Язык: Английский

Процитировано

62
Mechanistic flexibility of the retrosplenial cortex enables its contribution to spatial cognition DOI Creative Commons
Martin Stacho, Denise Manahan‐Vaughan

Trends in Neurosciences, Год журнала: 2022, Номер 45(4), С. 284 - 296

Опубликована: Фев. 17, 2022

The retrosplenial cortex (RC) is a brain structure crucial for spatial navigation and memory. It contains neurons such as head direction cells, border well other cells supporting contextual encoding. How complex diverse neuronal properties are generated by RC microcircuitry how they jointly orchestrate subsequent behavior remains enigmatic. Here, we consider recent findings that extend current knowledge about the modulates cognition. We argue integrative of allow combination idiothetic cues, relations (allocentric egocentric), environmental features (landmarks, boundaries, etc.) into map can dynamically support goal-directed navigation. Furthermore, mnemonic functions suggest its possible role in autobiographical information storage.

Язык: Английский

Процитировано

45
Dynamic compartmental computations in tuft dendrites of layer 5 neurons during motor behavior DOI
Yara Otor, Shay Achvat, Nathan Cermak

и другие.

Science, Год журнала: 2022, Номер 376(6590), С. 267 - 275

Опубликована: Апрель 14, 2022

Tuft dendrites of layer 5 pyramidal neurons form specialized compartments important for motor learning and performance, yet their computational capabilities remain unclear. Structural-functional mapping the tuft tree from cortex during tasks revealed two morphologically distinct populations tract (PTNs) that exhibit specific properties. Early bifurcating large nexus PTNs showed marked functional compartmentalization, representing different variable combinations within between hemi-trees. By contrast, late smaller synchronous activation. Dendritic structure dynamic recruitment N-methyl-d-aspartate (NMDA)-spiking mechanism explained differential compartmentalization patterns. Our findings support a dependent framework computations, in which independent amplification units can be combinatorically recruited to represent sequences same tree.

Язык: Английский

Процитировано

45
Compartmentalized dendritic plasticity during associative learning DOI
Simon d‘Aquin, András Szőnyi, Mathias Mahn

и другие.

Science, Год журнала: 2022, Номер 376(6590)

Опубликована: Апрель 14, 2022

Experience-dependent changes in behavior are mediated by long-term functional modifications brain circuits. Activity-dependent plasticity of synaptic input is a major underlying cellular process. Although we have detailed understanding and dendritic vitro, little known about the plastic properties active dendrites behaving animals. Using deep two-photon Ca 2+ imaging, investigated how sensory responses amygdala principal neurons develop upon classical fear conditioning, form associative learning. Fear conditioning induced differential somas regulated compartment-specific inhibition. Our results indicate that learning-induced can be uncoupled between soma dendrites, reflecting distinct microcircuit-level mechanisms increase computational capacity

Язык: Английский

Процитировано

44