Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Авг. 1, 2024
Behavioral
flexibility
relies
on
the
brain's
ability
to
switch
rapidly
between
multiple
tasks,
even
when
task
rule
is
not
explicitly
cued
but
must
be
inferred
through
trial
and
error.
The
underlying
neural
circuit
mechanism
remains
poorly
understood.
We
investigated
recurrent
networks
(RNNs)
trained
perform
an
analog
of
classic
Wisconsin
Card
Sorting
Test.
consist
two
modules
responsible
for
representation
sensorimotor
mapping,
respectively,
where
each
module
comprised
a
with
excitatory
neurons
three
major
types
inhibitory
neurons.
found
that
by
self-sustained
persistent
activity
across
trials,
error
monitoring
gated
mapping
emerged
from
training.
Systematic
dissection
RNNs
revealed
detailed
consistent
different
hyperparameters.
networks'
dynamical
trajectories
rules
resided
in
separate
subspaces
population
activity;
collapsed
performance
was
reduced
chance
level
dendrite-targeting
somatostatin-expressing
interneurons
were
silenced,
illustrating
how
phenomenological
description
representational
explained
specific
mechanism.
flexible
switching
unclear.
Here
authors
analyzed
modular
network
models
cell
reveal
uncued
switching.
Current Biology,
Год журнала:
2020,
Номер
30(11), С. 2116 - 2130.e6
Опубликована: Май 14, 2020
Animals
actively
interact
with
their
environment
to
gather
sensory
information.
There
is
conflicting
evidence
about
how
mice
use
vision
sample
environment.
During
head
restraint,
make
rapid
eye
movements
coupled
between
the
eyes,
similar
conjugate
saccadic
in
humans.
However,
when
are
free
move
heads,
more
complex
and
often
non-conjugate,
eyes
moving
opposite
directions.
We
combined
tracking
freely
found
both
observations
explained
by
two
eye-head
coupling
types,
associated
vestibular
mechanisms.
The
first
type
comprised
non-conjugate
movements,
which
compensate
for
tilt
changes
maintain
a
visual
field
relative
horizontal
ground
plane.
second
of
was
yaw
rotation
produce
"saccade
fixate"
gaze
pattern.
head-initiated
saccades,
moved
together
direction
but
during
subsequent
fixation
rotation.
This
saccade
fixate
pattern
humans
who
(with
or
without
movement)
rapidly
shift
relies
on
movements.
Both
couplings
were
maintained
social
interactions
visually
guided
object
tracking.
Even
head-restrained
mice,
invariably
attempted
motion.
Our
results
reveal
that
combine
highlight
similarities
differences
Journal of Neuroscience,
Год журнала:
2020,
Номер
41(5), С. 911 - 919
Опубликована: Дек. 18, 2020
Animals
evolved
in
complex
environments,
producing
a
wide
range
of
behaviors,
including
navigation,
foraging,
prey
capture,
and
conspecific
interactions,
which
vary
over
timescales
ranging
from
milliseconds
to
days.
Historically,
these
behaviors
have
been
the
focus
study
for
ecology
ethology,
while
systems
neuroscience
has
largely
focused
on
short
timescale
that
can
be
repeated
thousands
times
occur
highly
artificial
environments.
Thanks
recent
advances
machine
learning,
miniaturization,
computation,
it
is
newly
possible
freely
moving
animals
more
natural
conditions
applying
techniques:
performing
temporally
specific
perturbations,
modeling
behavioral
strategies,
recording
large
numbers
neurons
are
moving.
The
authors
this
review
group
scientists
with
deep
appreciation
common
aims
neuroscience,
ecology,
ethology.
We
believe
an
extremely
exciting
time
neuroscientist,
as
we
opportunity
grow
field,
embrace
interdisciplinary,
open,
collaborative
research
provide
new
insights
allow
researchers
link
knowledge
across
disciplines,
species,
scales.
Here
discuss
origins
context
our
own
work
highlight
how
combining
approaches
fields
provided
fresh
into
research.
hope
facilitates
some
interactions
alliances
helps
us
all
do
even
better
science,
together.
Neuroscience,
Год журнала:
2022,
Номер
489, С. 15 - 33
Опубликована: Фев. 17, 2022
Half
a
century
since
their
discovery
by
Llinás
and
colleagues,
dendritic
spikes
have
been
observed
in
various
neurons
different
brain
regions,
from
the
neocortex
cerebellum
to
basal
ganglia.
Dendrites
exhibit
terrifically
diverse
but
stereotypical
repertoire
of
spikes,
sometimes
specific
subregions
dendrite.
Despite
prevalence,
we
only
glimpse
into
role
behaving
animal.
This
article
aims
survey
full
range
found
excitatory
inhibitory
neurons,
compare
themin
vivoversusin
vitro,
discuss
new
studies
describing
human
cortex.
We
focus
on
neocortical
hippocampal
present
roadmap
identify
understand
broader
single-cell
computation.
Proceedings of the National Academy of Sciences,
Год журнала:
2021,
Номер
118(30)
Опубликована: Июль 23, 2021
Significance
An
active
pyramidal
cell
model,
constrained
by
physiological
and
anatomical
data,
was
used
to
simulate
dendritic
integration
in
vivo.
The
model
shows
that
small
numbers
of
strong
excitatory
synapses
can
trigger
Na
+
NMDA
spikes.
Moreover,
only
a
few
spikes
are
sufficient
drive
single
output
action
potential.
As
consequence,
as
1%
the
synaptic
inputs
neuron
determine
tuning
somatic
These
results
suggest
help
make
sensory
representations
more
efficient
flexible:
they
require
fewer
connections
sustain
them,
number
need
be
changed
encode
different
stimulus
alter
response
properties
neuron.
Trends in Neurosciences,
Год журнала:
2022,
Номер
45(4), С. 284 - 296
Опубликована: Фев. 17, 2022
The
retrosplenial
cortex
(RC)
is
a
brain
structure
crucial
for
spatial
navigation
and
memory.
It
contains
neurons
such
as
head
direction
cells,
border
well
other
cells
supporting
contextual
encoding.
How
complex
diverse
neuronal
properties
are
generated
by
RC
microcircuitry
how
they
jointly
orchestrate
subsequent
behavior
remains
enigmatic.
Here,
we
consider
recent
findings
that
extend
current
knowledge
about
the
modulates
cognition.
We
argue
integrative
of
allow
combination
idiothetic
cues,
relations
(allocentric
egocentric),
environmental
features
(landmarks,
boundaries,
etc.)
into
map
can
dynamically
support
goal-directed
navigation.
Furthermore,
mnemonic
functions
suggest
its
possible
role
in
autobiographical
information
storage.
Science,
Год журнала:
2022,
Номер
376(6590), С. 267 - 275
Опубликована: Апрель 14, 2022
Tuft
dendrites
of
layer
5
pyramidal
neurons
form
specialized
compartments
important
for
motor
learning
and
performance,
yet
their
computational
capabilities
remain
unclear.
Structural-functional
mapping
the
tuft
tree
from
cortex
during
tasks
revealed
two
morphologically
distinct
populations
tract
(PTNs)
that
exhibit
specific
properties.
Early
bifurcating
large
nexus
PTNs
showed
marked
functional
compartmentalization,
representing
different
variable
combinations
within
between
hemi-trees.
By
contrast,
late
smaller
synchronous
activation.
Dendritic
structure
dynamic
recruitment
N-methyl-d-aspartate
(NMDA)-spiking
mechanism
explained
differential
compartmentalization
patterns.
Our
findings
support
a
dependent
framework
computations,
in
which
independent
amplification
units
can
be
combinatorically
recruited
to
represent
sequences
same
tree.
Experience-dependent
changes
in
behavior
are
mediated
by
long-term
functional
modifications
brain
circuits.
Activity-dependent
plasticity
of
synaptic
input
is
a
major
underlying
cellular
process.
Although
we
have
detailed
understanding
and
dendritic
vitro,
little
known
about
the
plastic
properties
active
dendrites
behaving
animals.
Using
deep
two-photon
Ca
2+
imaging,
investigated
how
sensory
responses
amygdala
principal
neurons
develop
upon
classical
fear
conditioning,
form
associative
learning.
Fear
conditioning
induced
differential
somas
regulated
compartment-specific
inhibition.
Our
results
indicate
that
learning-induced
can
be
uncoupled
between
soma
dendrites,
reflecting
distinct
microcircuit-level
mechanisms
increase
computational
capacity