Journal of genetics and genomics/Journal of Genetics and Genomics,
Год журнала:
2023,
Номер
50(5), С. 295 - 304
Опубликована: Янв. 9, 2023
Primary
cilia
are
hair-like
structures
that
protrude
from
the
cell
surface.
They
capable
of
sensing
external
cues
and
conveying
a
vast
array
signals
into
cells
to
regulate
variety
physiological
activities.
Mutations
in
cilium-associated
genes
linked
group
diseases
with
overlapping
clinical
manifestations,
collectively
known
as
ciliopathies.
A
significant
proportion
human
ciliopathy
cases
accompanied
by
metabolic
disorders
such
obesity
type
2
diabetes.
Nevertheless,
mechanisms
through
which
dysfunction
primary
contributes
complex.
In
this
review,
we
present
an
overview
highlight
obesity-related
We
also
discuss
potential
role
peripheral
organs,
focus
on
adipose
tissues.
addition,
emphasize
significance
central
regulation
obesity,
especially
involvement
ciliary
signaling
hypothalamic
control
feeding
behavior.
This
review
therefore
proposes
framework
both
cilia,
may
benefit
further
exploration
regulation.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 13, 2024
Gastric
pain
has
limited
treatment
options
and
the
mechanisms
within
central
circuitry
remain
largely
unclear.
This
study
investigates
in
gastric
induced
by
noxious
distension
(GD)
mice.
Here,
we
identified
that
nucleus
tractus
solitarius
(NTS)
serves
as
first-level
center
of
pain,
primarily
via
vagus
nerve.
The
prelimbic
cortex
(PL)
is
engaged
perception
pain.
lateral
parabrachial
(LPB)
paraventricular
thalamic
(PVT)
are
crucial
regions
for
synaptic
transmission
from
NTS
to
PL.
glutamatergic
tetra-synaptic
NTS–LPB–PVT–PL
necessary
sufficient
processing
Overall,
our
finding
reveals
a
transmits
nociceptive
signaling
nerve
It
provides
an
insight
into
ascending
pathway
offers
potential
therapeutic
targets
relieving
visceral
remains
authors
identify
circuit
basis
clinical
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 8, 2025
Recent
single-cell
RNA
sequencing
study
suggested
that
CRABP1
expressing
neurons
in
the
arcuate
nucleus
(ARCCRABP1
neurons)
were
a
distinct
group
of
neurons.
However,
physiological
role
ARCCRABP1
remains
unexplored.
Here,
we
demonstrated
played
crucial
regulation
energy
homeostasis
male
mice.
Ablation
resulted
obesity
and
diabetic
phenotype
By
employing
chemogenetic
or
optogenetic
manipulation
techniques,
inhibition
activation
an
increase
decrease
food
intake,
respectively.
The
axon
terminals
from
these
project
to
several
brain
regions
implicated
feeding
such
as
PVH,
BNST,
PBN,
NTS.
Optogenetic
axons
within
significant
alterations
intake
behavior
Furthermore,
electrophysiological
studies
induces
depolarization
POMC
hypothalamus.
hormone
stimulation
showed
most
respond
insulin.
Collectively,
our
findings
demonstrate
represent
neuronal
subtype
involved
regulation.
AgRP
hypothalamus
widely
known
regulate
balance.
authors
show
are
identified
new
player
influencing
appetite
metabolism.
iScience,
Год журнала:
2023,
Номер
26(7), С. 107124 - 107124
Опубликована: Июнь 16, 2023
Gene
regulatory
network
(GRN)
inference
is
an
integral
part
of
understanding
physiology
and
disease.
Single
cell/nuclei
RNA-seq
(scRNA-seq/snRNA-seq)
data
has
been
used
to
elucidate
cell-type
GRNs;
however,
the
accuracy
speed
current
scRNAseq-based
GRN
approaches
are
suboptimal.
Here,
we
present
Cell
INtegrative
(SCING),
a
gradient
boosting
mutual
information-based
approach
for
identifying
robust
GRNs
from
scRNA-seq,
snRNA-seq,
spatial
transcriptomics
data.
Performance
evaluation
using
Perturb-seq
datasets,
held-out
data,
mouse
cell
atlas
combined
with
DisGeNET
database
demonstrates
improved
biological
interpretability
SCING
compared
existing
methods.
We
applied
entire
single
atlas,
human
Alzheimer's
disease
(AD),
AD
transcriptomics.
reveal
unique
subnetwork
modeling
capabilities,
have
intrinsic
capacity
correct
batch
effects,
retrieve
relevant
genes
pathways,
informative
on
specificity
pathogenesis.
Journal of genetics and genomics/Journal of Genetics and Genomics,
Год журнала:
2023,
Номер
50(5), С. 295 - 304
Опубликована: Янв. 9, 2023
Primary
cilia
are
hair-like
structures
that
protrude
from
the
cell
surface.
They
capable
of
sensing
external
cues
and
conveying
a
vast
array
signals
into
cells
to
regulate
variety
physiological
activities.
Mutations
in
cilium-associated
genes
linked
group
diseases
with
overlapping
clinical
manifestations,
collectively
known
as
ciliopathies.
A
significant
proportion
human
ciliopathy
cases
accompanied
by
metabolic
disorders
such
obesity
type
2
diabetes.
Nevertheless,
mechanisms
through
which
dysfunction
primary
contributes
complex.
In
this
review,
we
present
an
overview
highlight
obesity-related
We
also
discuss
potential
role
peripheral
organs,
focus
on
adipose
tissues.
addition,
emphasize
significance
central
regulation
obesity,
especially
involvement
ciliary
signaling
hypothalamic
control
feeding
behavior.
This
review
therefore
proposes
framework
both
cilia,
may
benefit
further
exploration
regulation.
