A unified mechanism for innate and learned visual landmark guidance in the insect central complex

PLoS Computational Biology, Год журнала: 2021, Номер 17(9), С. e1009383 - e1009383

Опубликована: Сен. 23, 2021

Insects can navigate efficiently in both novel and familiar environments, this requires flexiblity how they are guided by sensory cues. A prominent landmark, for example, elicit strong innate behaviours (attraction or menotaxis) but also be used, after learning, as a specific directional cue part of navigation memory. However, the mechanisms that allow pathways to co-exist, interact override each other largely unknown. Here we propose model behavioural integration learned guidance based on neuroanatomy central complex (CX), adapted control landmark behaviours. We consider reward signal provided either an attraction landmarks long-term visual memory mushroom bodies (MB) modulates formation local vector CX. Using operant strategy simulated agent exploring simple world containing single cue, show generated short-term support steering behaviour. In addition, architecture is consistent with observed effects unilateral MB lesions ants cause reversion suggest CX interpreted transforming rewarding (positive negative) signals into mapping environment describes geometrical attractiveness (or repulsion). discuss scheme might represent ideal way combine multisensory information gathered during exploration optimal integration.

Язык: Английский

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Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex

Journal of Comparative Physiology A, Год журнала: 2023, Номер 209(4), С. 679 - 720

Опубликована: Март 17, 2023

The representation and integration of internal external cues is crucial for any organism to execute appropriate behaviors. In insects, a highly conserved region the brain, central complex (CX), functions in spatial information behavioral states, as well transformation this into desired navigational commands. How does relatively invariant structure enable incorporation from diversity anatomical, behavioral, ecological niches occupied by insects? Here, we examine input channels CX context their development evolution. Insect brains develop ~ 100 neuroblasts per hemisphere that divide systematically form "lineages" sister neurons, project target neuropils along anatomically characteristic tracts. Overlaying developmental tract onto recently generated Drosophila "hemibrain" connectome integrating with anatomical physiological recording neurons other species, observe neuropil lineage-specific innervation, connectivity, activity profiles channels. We posit proliferative potential lineage-based architecture modification neural networks across existing, novel, deprecated modalities species-specific manner, thus forming substrate evolution diversification insect circuits.

Язык: Английский

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Network Statistics of the Whole-Brain Connectome ofDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 29, 2023

Abstract Brains comprise complex networks of neurons and connections. Network analysis applied to the wiring diagrams brains can offer insights into how support computations regulate information flow. The completion first whole-brain connectome an adult Drosophila , largest date, containing 130,000 millions connections, offers unprecedented opportunity analyze its network properties topological features. To gain local connectivity, we computed prevalence two- three-node motifs, examined their strengths neurotransmitter compositions, compared these metrics with other animals. We discovered that fly brain displays rich club organization, a large population (30% percent connectome) highly connected neurons. identified subsets may serve as integrators or broadcasters signals. Finally, subnetworks based on 78 anatomically defined regions neuropils. These data products are shared within FlyWire Codex will foundation for models experiments exploring relationship between neural activity anatomical structure.

Язык: Английский

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Connectomic reconstruction predicts visual features used for navigation

Nature, Год журнала: 2024, Номер 634(8032), С. 181 - 190

Опубликована: Окт. 2, 2024

Язык: Английский

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Neural circuits for goal-directed navigation across species

Trends in Neurosciences, Год журнала: 2024, Номер 47(11), С. 904 - 917

Опубликована: Окт. 10, 2024

Язык: Английский

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