Distinct place cell dynamics in CA1 and CA3 encode experience in new environments

Nature Communications, Год журнала: 2021, Номер 12(1)

Опубликована: Май 20, 2021

Abstract When exploring new environments animals form spatial memories that are updated with experience and retrieved upon re-exposure to the same environment. The hippocampus is thought support these memory processes, but how this achieved by different subnetworks such as CA1 CA3 remains unclear. To understand hippocampal representations emerge evolve during familiarization, we performed 2-photon calcium imaging in mice running virtual compared trial-to-trial dynamics of place cells over days. We find fields rapidly tend shift backwards from remap environment a day later. In contrast, gradually show more stable day-to-day dynamics. These results reflect roles processing familiarization constrain potential mechanisms them.

Язык: Английский

---

No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

Neuron, Год журнала: 2021, Номер 109(14), С. 2239 - 2255

Опубликована: Май 19, 2021

Язык: Английский

---

The Neuropsychology of Anxiety

Oxford University Press eBooks, Год журнала: 2024, Номер unknown

Опубликована: Май 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Язык: Английский

---

Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory

Molecular Psychiatry, Год журнала: 2023, Номер 28(8), С. 3207 - 3219

Опубликована: Июнь 27, 2023

Tremendous strides have been made in our understanding of the neurobiological substrates memory - so-called "engram". Here, we integrate recent progress engram field to illustrate how neurons transform across "lifespan" a from initial encoding, consolidation and retrieval, ultimately forgetting. To do so, first describe cell-intrinsic properties shape emergence at encoding. Second, highlight these encoding preferentially participate synaptic- systems-level memory. Third, changes during guide neural reactivation facilitate recall. Fourth, mechanisms forgetting, can counteract established consolidation, retrieval. Motivated by experimental results four sections, conclude proposing some conceptual extensions traditional view engram, including broadening cell-type participation within engrams stages. In collection, review synthesizes general principles stages, describes future avenues further understand dynamic engram.

Язык: Английский

---

Barcoding of episodic memories in the hippocampus of a food-caching bird

Cell, Год журнала: 2024, Номер 187(8), С. 1922 - 1935.e20

Опубликована: Март 29, 2024

Язык: Английский

---

The homogenous hippocampus: How hippocampal cells process available and potential goals

Progress in Neurobiology, Год журнала: 2024, Номер 240, С. 102653 - 102653

Опубликована: Июль 2, 2024

We present here a view of the firing patterns hippocampal cells that is contrary, both functionally and anatomically, to conventional wisdom. argue hippocampus responds efference copies goals encoded elsewhere; it uses these detect resolve conflict or interference between in general. While can involve space, do not encode spatial (or other special types of) memory, as such. also transverse circuits operate an essentially homogeneous way along its length. The apparently different functions parts (e.g. memory retrieval versus anxiety) result from (situational/motivational) inputs on which those perform same fundamental computational operations. On this view, key role iterative adjustment, via Papez-like circuits, synaptic weights cell assemblies elsewhere.

Язык: Английский

---

The brain in motion: How ensemble fluidity drives memory-updating and flexibility

eLife, Год журнала: 2020, Номер 9

Опубликована: Дек. 29, 2020

While memories are often thought of as flashbacks to a previous experience, they do not simply conserve veridical representations the past but must continually integrate new information ensure survival in dynamic environments. Therefore, ‘drift’ neural firing patterns, typically construed disruptive ‘instability’ or an undesirable consequence noise, may actually be useful for updating memories. In our view, continual modifications memory reconcile classical theories stable traces with drift. Here we review how updated through recruitment neuronal ensembles on basis excitability and functional connectivity at time learning. Overall, emphasize importance considering static entities, instead flexible network states that reactivate evolve across experience.

Язык: Английский

---

Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective

Molecular Psychiatry, Год журнала: 2021, Номер 27(1), С. 403 - 421

Опубликована: Май 14, 2021

Abstract Adult hippocampal neurogenesis (AHN) represents a remarkable form of neuroplasticity that has increasingly been linked to the stress response in recent years. However, hippocampus does not itself support expression different dimensions response. Moreover, main functions are essentially preserved under AHN depletion and adult-born immature neurons (abGNs) have no extrahippocampal projections, which questions mechanisms by abGNs influence supported brain areas far from hippocampus. Within this framework, we propose through its computational influences is pivotal shaping adaption environmental demands, underlying role The with high input convergence output divergence hub, ideally positioned (1) detect cues contexts past, current predicted stressful experiences, (2) supervise at cognitive, affective, behavioral, physiological levels. appears bias computations toward enhanced conjunctive encoding pattern separation, promoting contextual discrimination cognitive flexibility, reducing proactive interference generalization experiences safe contexts. These effects result gating downstream more accurate contextualized information, enabling be appropriately set specific Here, first provide an integrative perspective functional involvement phenomenological overview We then examine mechanistic underpinning describe potential implications accompanying

Язык: Английский

---

The hippocampus as the switchboard between perception and memory

Proceedings of the National Academy of Sciences, Год журнала: 2021, Номер 118(50)

Опубликована: Дек. 8, 2021

Significance How do we adaptively switch from perceiving the external world to retrieving goal-relevant internal memories? To tackle this question, used—in a cued-recall paradigm—direct intracranial recordings human hippocampus complemented by high-density scalp electroencephalography (EEG). We found that hippocampal signal ∼500 ms after perceptual cue marks conversion (perceptual) (mnemonic) representations. This sets in motion recall cascade involving posterior parietal and medial prefrontal cortex, revealed via source-localized time-resolved EEG alpha power. Together, these results unveil hippocampal–cortical dynamics supporting rapid flexible memory recall.

Язык: Английский

---

Covert capture and attenuation of a hippocampus-dependent fear memory

Nature Neuroscience, Год журнала: 2021, Номер 24(5), С. 677 - 684

Опубликована: Апрель 1, 2021

Язык: Английский

---