PIP ₂ corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity

Proceedings of the National Academy of Sciences, Год журнала: 2021, Номер 118(17)

Опубликована: Апрель 19, 2021

Significance Years before the emergence of infarctions or significant cognitive decline, patients with cerebral small vessel disease (SVD) show a deterioration in ability brain to augment blood flow locally response increases neuronal activity (functional hyperemia). Using well-characterized genetic mouse model hereditary form SVD, we determined molecular defect at play capillary endothelial cells. We found that SVD is associated reduced synthesis phospholipid PIP 2 , which prevents Kir2.1 channel-initiated capillary-to-arteriole electrical signaling supports vasodilatory responses during functional hyperemia. further systemic injection exogenous sufficient rescue this deficit mice, restoring adequate activation.

Язык: Английский

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Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain: a transdiagnostic multimodal meta-analysis of structural and functional MRI studies

Neuropsychopharmacology, Год журнала: 2022, Номер 47(5), С. 1071 - 1080

Опубликована: Янв. 20, 2022

Abstract Major depressive disorder (MDD), anxiety disorders (ANX), and chronic pain (CP) are closely-related with both high degrees of comorbidity among them shared risk factors. Considering this multi-level overlap, but also the distinct phenotypes disorders, we hypothesized common disorder-specific changes large-scale brain systems, which mediate neural mechanisms impaired behavioral traits, in MDD, ANX, CP. To identify such changes, conducted a transdiagnostic, multimodal meta-analysis structural functional MRI-studies investigating gray matter volume (GMV) intrinsic connectivity (iFC) networks across The study was preregistered at PROSPERO (CRD42019119709). 320 studies comprising 10,931 patients 11,135 healthy controls were included. Across focused on GMV-decrease insular medial-prefrontal cortices, located mainly within so-called default-mode salience networks. Disorder-specific comprised hyperconnectivity between frontoparietal hypoconnectivity limbic MDD; network medial-temporal cortices ANX; GMV-increase medial temporal lobes Common suggested correlate for possibly neuro-behavioral chronification mechanisms. might underlie additional

Язык: Английский

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Impact of multisession 40Hz tACS on hippocampal perfusion in patients with Alzheimer’s disease

Alzheimer s Research & Therapy, Год журнала: 2021, Номер 13(1)

Опубликована: Дек. 1, 2021

Alzheimer's disease (AD) is associated with alterations in cortical perfusion that correlate cognitive impairment. Recently, neural activity the gamma band has been identified as a driver of arteriolar vasomotion while, on other hand, induction preclinical models AD shown to promote protein clearance and protection.

Язык: Английский

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Neural correlates of blood flow measured by ultrasound

Neuron, Год журнала: 2022, Номер 110(10), С. 1631 - 1640.e4

Опубликована: Март 11, 2022

Functional ultrasound imaging (fUSI) is an appealing method for measuring blood flow and thus infer brain activity, but it relies on the physiology of neurovascular coupling requires extensive signal processing. To establish to what degree fUSI trial-by-trial signals reflect neural we performed simultaneous recordings with Neuropixels probes in awake mice. strongly correlated slow (<0.3 Hz) fluctuations local firing rate were closely predicted by smoothed neurons, particularly putative inhibitory neurons. The optimal smoothing filter had a width ∼3 s, matched hemodynamic response function mice, was invariant across mice stimulus conditions, similar cortex hippocampus. also spatially: rates as highly hemispheres signals. Thus, measured bears simple accurate relationship neuronal firing.

Язык: Английский

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Functional Connectivity of the Brain Across Rodents and Humans

Frontiers in Neuroscience, Год журнала: 2022, Номер 16

Опубликована: Март 8, 2022

Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in blood oxygen level-dependent (BOLD) signal, is increasingly utilized for investigation of brain's physiological and pathological activity. Rodents, as a typical animal model neuroscience, play an important role studies that examine neuronal processes underpin BOLD signal connectivity results. Translating this knowledge from rodents to humans requires basic similarities differences across species terms both resulting connectivity. This review begins by examining anatomical features, acquisition parameters, preprocessing techniques, factors contribute Homologous networks are compared species, aspects such topography global relationship between structural examined. Time-varying features connectivity, obtained sliding windowed approaches, quasi-periodic patterns, coactivation species. Applications demonstrating use rs-fMRI translational tool cross-species analysis discussed, with emphasis on neurological psychiatric disorders. Finally, open questions presented encapsulate future direction field.

Язык: Английский

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Imaging of the pial arterial vasculature of the human brain in vivo using high-resolution 7T time-of-flight angiography

eLife, Год журнала: 2022, Номер 11

Опубликована: Апрель 29, 2022

The pial arterial vasculature of the human brain is only blood supply to neocortex, but quantitative data on morphology and topology these mesoscopic arteries (diameter 50–300 µm) remains scarce. Because it commonly assumed that flow velocities in vessels are prohibitively slow, non-invasive time-of-flight magnetic resonance angiography (TOF-MRA)—which well suited high 3D imaging resolutions—has not been applied arteries. Here, we provide a theoretical framework outlines how TOF-MRA can visualize small vivo, by employing extremely voxels at size individual vessels. We then evidence for this theory 140 µm isotropic resolution using 7 Tesla (T) (MRI) scanner prospective motion correction, show one voxel width diameter be detected. conclude limited slow flow, instead achievable image resolution. This study represents first targeted, comprehensive account vivo brain. ultra-high-resolution will enable characterization vascular anatomy across investigate patterns relationships between functional architecture.

Язык: Английский

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Pupil size reflects activation of subcortical ascending arousal system nuclei during rest

eLife, Год журнала: 2023, Номер 12

Опубликована: Июнь 27, 2023

Neuromodulatory nuclei that are part of the ascending arousal system (AAS) play a crucial role in regulating cortical state and optimizing task performance. Pupil diameter, under constant luminance conditions, is increasingly used as an index activity these AAS nuclei. Indeed, task-based functional imaging studies humans have begun to provide evidence stimulus-driven pupil-AAS coupling. However, whether there such tight coupling during rest not clear. To address this question, we examined simultaneously acquired resting-state fMRI pupil-size data from 74 participants, focusing on six nuclei: locus coeruleus, ventral tegmental area, substantia nigra, dorsal median raphe nuclei, cholinergic basal forebrain. Activation all was optimally correlated with pupil size at 0-2 s lags, suggesting spontaneous changes were almost immediately followed by corresponding BOLD-signal AAS. These results suggest occur states can be noninvasive general Importantly, nature appears vastly different relatively slow canonical hemodynamic response function has been characterize task-related

Язык: Английский

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Minute-scale oscillatory sequences in medial entorhinal cortex

Nature, Год журнала: 2023, Номер 625(7994), С. 338 - 344

Опубликована: Дек. 20, 2023

Abstract The medial entorhinal cortex (MEC) hosts many of the brain’s circuit elements for spatial navigation and episodic memory, operations that require neural activity to be organized across long durations experience 1 . Whereas location is known encoded by spatially tuned cell types in this brain region 2,3 , little about how cells tied together over time at behaviourally relevant scales, second-to-minute regime. Here we show MEC neuronal has capacity into ultraslow oscillations, with periods ranging from tens seconds minutes. During these further periodic sequences. Oscillatory sequences manifested while mice ran free pace on a rotating wheel darkness, no change or running direction scheduled rewards. involved nearly entire population, transcended epochs immobility. Similar were not observed neighbouring parasubiculum visual cortex. Ultraslow oscillatory may have potential couple neurons circuits extended scales serve as template new sequence formation during memory formation.

Язык: Английский

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A natural language fMRI dataset for voxelwise encoding models

Scientific Data, Год журнала: 2023, Номер 10(1)

Опубликована: Авг. 23, 2023

Abstract Speech comprehension is a complex process that draws on humans’ abilities to extract lexical information, parse syntax, and form semantic understanding. These sub-processes have traditionally been studied using separate neuroimaging experiments attempt isolate specific effects of interest. More recently it has become possible study all stages language in single experiment narrative natural stimuli. The resulting data are richly varied at every level, enabling analyses can probe everything from spectral representations high-level meaning. We provide dataset containing BOLD fMRI responses recorded while 8 participants each listened 27 complete, natural, stories (~6 hours). This includes pre-processed raw MRIs, as well hand-constructed 3D cortical surfaces for participant. To address the challenges analyzing naturalistic data, this accompanied by python library basic code creating voxelwise encoding models. Altogether, provides large novel resource understanding speech processing human brain.

Язык: Английский

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Long-wavelength traveling waves of vasomotion modulate the perfusion of cortex

Neuron, Год журнала: 2024, Номер 112(14), С. 2349 - 2367.e8

Опубликована: Май 22, 2024

Язык: Английский

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