Cell,
Год журнала:
2020,
Номер
183(6), С. 1586 - 1599.e10
Опубликована: Ноя. 6, 2020
The
hippocampus
is
crucial
for
spatial
navigation
and
episodic
memory
formation.
Hippocampal
place
cells
exhibit
spatially
selective
activity
within
an
environment
have
been
proposed
to
form
the
neural
basis
of
a
cognitive
map
space
that
supports
these
mnemonic
functions.
However,
direct
influence
cell
on
behavior
has
not
yet
demonstrated.
Using
'all-optical'
combination
simultaneous
two-photon
calcium
imaging
optogenetics,
we
identified
selectively
activated
encoded
behaviorally
relevant
locations
in
virtual
reality
environment.
Targeted
stimulation
small
number
was
sufficient
bias
animals
during
task,
providing
causal
evidence
hippocampal
actively
support
memory.
Cell,
Год журнала:
2023,
Номер
186(3), С. 543 - 559.e19
Опубликована: Янв. 19, 2023
Learning
has
been
associated
with
modifications
of
synaptic
and
circuit
properties,
but
the
precise
changes
storing
information
in
mammals
have
remained
largely
unclear.
We
combined
genetically
targeted
voltage
imaging
optogenetic
activation
silencing
pre-
post-synaptic
neurons
to
study
mechanisms
underlying
hippocampal
behavioral
timescale
plasticity.
In
mice
navigating
a
virtual-reality
environment,
individual
CA1
cells
at
specific
places
induced
stable
representations
these
cells.
Optical
elicitation,
recording,
modulation
transmission
behaving
revealed
that
activity
presynaptic
CA2/3
was
required
for
induction
plasticity
and,
furthermore,
during
place
fields
single
cells,
input
from
onto
same
potentiated.
These
results
reveal
implementation
define
methodology
resolve
learning
memory
mammals.
Oxford University Press eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 7, 2024
Abstract
The
Neuropsychology
of
Anxiety
first
appeared
in
1982
as
the
volume
Oxford
Psychology
Series,
and
it
quickly
established
itself
classic
work
on
subject.
It
second
edition
(appearing
2000)
have
been
cited
at
a
steadily
increasing
rate
passing
500/year
2017.
field
has
continued
to
expand
last
quarter
century
necessitating
this
third
edition.
This
completely
updated
revised
(with
many
figures
converted
colour)
retains
original
core
concepts
while
expanding
often
simplifying
details.
includes
new
chapter
prefrontal
cortex,
which
integrates
frontal
hippocampal
views
anxiety
an
extensively
modified
personality
providing
basis
for
further
developments
Reinforcement
Sensitivity
Theory.
book
is
essential
postgraduate
students
researchers
experimental
psychology
neuroscience,
well
all
clinical
psychologists
psychiatrists.
While
memories
are
often
thought
of
as
flashbacks
to
a
previous
experience,
they
do
not
simply
conserve
veridical
representations
the
past
but
must
continually
integrate
new
information
ensure
survival
in
dynamic
environments.
Therefore,
‘drift’
neural
firing
patterns,
typically
construed
disruptive
‘instability’
or
an
undesirable
consequence
noise,
may
actually
be
useful
for
updating
memories.
In
our
view,
continual
modifications
memory
reconcile
classical
theories
stable
traces
with
drift.
Here
we
review
how
updated
through
recruitment
neuronal
ensembles
on
basis
excitability
and
functional
connectivity
at
time
learning.
Overall,
emphasize
importance
considering
static
entities,
instead
flexible
network
states
that
reactivate
evolve
across
experience.
Network Neuroscience,
Год журнала:
2021,
Номер
unknown, С. 1 - 28
Опубликована: Авг. 13, 2021
Abstract
Network
models
describe
the
brain
as
sets
of
nodes
and
edges
that
represent
its
distributed
organization.
So
far,
most
discoveries
in
network
neuroscience
have
prioritized
insights
highlight
distinct
groupings
specialized
functional
contributions
nodes.
Importantly,
these
are
determined
expressed
by
web
their
interrelationships,
formed
edges.
Here,
we
underscore
important
made
for
understanding
Different
types
different
relationships,
including
connectivity
similarity
among
Adopting
a
specific
definition
can
fundamentally
alter
how
analyze
interpret
network.
Furthermore,
associate
into
collectives
higher
order
arrangements,
time
series,
form
edge
communities
provide
topology
complementary
to
traditional
node-centric
perspective.
Focusing
on
edges,
or
dynamic
information
they
provide,
discloses
previously
underappreciated
aspects
structural
Annual Review of Psychology,
Год журнала:
2021,
Номер
73(1), С. 187 - 215
Опубликована: Сен. 18, 2021
By
linking
the
past
with
future,
our
memories
define
sense
of
identity.
Because
human
memory
engages
conscious
realm,
its
examination
has
historically
been
approached
from
language
and
introspection
proceeded
largely
along
separate
parallel
paths
in
humans
other
animals.
Here,
we
first
highlight
achievements
limitations
this
mind-based
approach
make
case
for
a
new
brain-based
understanding
declarative
focus
on
hippocampal
physiology.
Next,
discuss
interleaved
nature
common
physiological
mechanisms
navigation
real
mental
spacetime.
We
suggest
that
distinguishing
feature
types
is
whether
they
subserve
actions
single
or
multiple
uses.
Finally,
contrast
to
persisting
view
mind
as
highly
plastic
blank
slate
ready
world
imprint,
hypothesize
neuronal
networks
are
endowed
reservoir
neural
trajectories,
challenge
faced
by
brain
how
select
match
preexisting
trajectories
events
world.
