Gut proinflammatory bacteria is associated with abnormal functional connectivity of hippocampus in unmedicated patients with major depressive disorder DOI Creative Commons

Shu Xiao,

Zibin Yang,

Hong Yan

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 16, 2024

Abstract Accumulating evidence has revealed the gut bacteria dysbiosis and brain hippocampal functional structural alterations in major depressive disorder (MDD). However, potential relationship between microbiota function patients with MDD is still very limited. Data of resting-state magnetic resonance imaging were acquired from 44 unmedicated 42 demographically matched healthy controls (HCs). Severn pairs hippocampus subregions (the bilateral cornu ammonis [CA1-CA3], dentate gyrus (DG), entorhinal cortex, hippocampal–amygdaloid transition area, subiculum) selected as seeds connectivity (FC) analysis. Additionally, fecal samples participants collected 16S rDNA amplicon sequencing was used to identify altered relative abundance microbiota. Then, association analysis conducted investigate relationships abnormal FC microbiome features. Also, subregion values levels features separately or together support vector machine models distinguishing HCs. Compared HCs, exhibited increased left (CA2, CA3 DG) right (CA2 CA3), decreased posterior cingulate cortex. In addition, we found that level proinflammatory (i.e., Enterobacteriaceae ) significantly increased, whereas short-chain fatty acids producing-bacteria Prevotellaceae, Agathobacter Clostridium patients. Furthermore, CA3- CA3) positively correlated MDD. Moreover, patterns considered combination, best discrimination obtained (AUC = 0.92). These findings may provide insights into role underlying neuropathology

Язык: Английский

Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells DOI Creative Commons
Daniel Franjic, Mario Škarica, Shaojie Ma

и другие.

Neuron, Год журнала: 2021, Номер 110(3), С. 452 - 469.e14

Опубликована: Ноя. 18, 2021

The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate potential cellular diversity, we profiled single-nucleus transcriptomes five subregions humans, macaques, pigs. Integrated cross-species analysis revealed robust transcriptomic histologic signatures of neurogenesis the adult mouse, pig, macaque but not humans. Doublecortin (DCX), a widely accepted marker newly generated granule cells, was detected diverse human neurons, it did define immature neuron populations. explore species differences diversity implications for disease, characterized subregion-specific, transcriptomically defined cell types transitional changes from three-layered archicortex six-layered neocortex. Notably, METTL7B subregion-specific excitatory neurons astrocytes primates, associated with endoplasmic reticulum lipid droplet proteins, including disease-related proteins. This resource reveals cell-type- species-specific properties shaping function.

Язык: Английский

Процитировано

238
Impact of neurodegenerative diseases on human adult hippocampal neurogenesis DOI
Julia Terreros‐Roncal, Elena P. Moreno‐Jiménez, Miguel Flor‐García

и другие.

Science, Год журнала: 2021, Номер 374(6571), С. 1106 - 1113

Опубликована: Окт. 22, 2021

Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s dementia Lewy bodies, frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development changes expression differentiation markers. The ratio quiescent proliferating neural stem shifted, homeostasis neurogenic niche was altered. Aging diseases reduced phagocytic capacity microglia, triggered astrogliosis, altered microvasculature gyrus. Thus, enhanced vulnerability AHN neurodegeneration might underlie dysfunction during physiological pathological aging humans.

Язык: Английский

Процитировано

226
Molecular landscapes of human hippocampal immature neurons across lifespan DOI
Yi Zhou, Yijing Su, Shiying Li

и другие.

Nature, Год журнала: 2022, Номер 607(7919), С. 527 - 533

Опубликована: Июль 6, 2022

Язык: Английский

Процитировано

214
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS DOI Creative Commons
Roberta De Ceglia, Ada Ledonne, David Litvin

и другие.

Nature, Год журнала: 2023, Номер 622(7981), С. 120 - 129

Опубликована: Сен. 6, 2023

Abstract Multimodal astrocyte–neuron communications govern brain circuitry assembly and function 1 . For example, through rapid glutamate release, astrocytes can control excitability, plasticity synchronous activity 2,3 of synaptic networks, while also contributing to their dysregulation in neuropsychiatric conditions 4–7 communicate fast focal they should possess an apparatus for Ca 2+ -dependent exocytosis similar neurons 8–10 However, the existence this mechanism has been questioned 11–13 owing inconsistent data 14–17 a lack direct supporting evidence. Here we revisited astrocyte hypothesis by considering emerging molecular heterogeneity 18–21 using molecular, bioinformatic imaging approaches, together with cell-specific genetic tools that interfere vivo. By analysing existing single-cell RNA-sequencing databases our patch-seq data, identified nine molecularly distinct clusters hippocampal astrocytes, among which found notable subpopulation selectively expressed synaptic-like glutamate-release machinery localized discrete sites. Using GluSnFR-based 22 situ vivo, corresponding subgroup responds reliably astrocyte-selective stimulations subsecond release events at spatially precise hotspots, were suppressed astrocyte-targeted deletion vesicular transporter (VGLUT1). Furthermore, or its isoform VGLUT2 revealed specific contributions glutamatergic cortico-hippocampal nigrostriatal circuits during normal behaviour pathological processes. uncovering atypical specialized adult brain, provide insights into complex roles central nervous system (CNS) physiology diseases, identify potential therapeutic target.

Язык: Английский

Процитировано

158
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data DOI
Martin Jinye Zhang, Kangcheng Hou, Kushal K. Dey

и другие.

Nature Genetics, Год журнала: 2022, Номер 54(10), С. 1572 - 1580

Опубликована: Сен. 1, 2022

Язык: Английский

Процитировано

134
Insights into Alzheimer’s disease from single-cell genomic approaches DOI
Mitchell H. Murdock, Li‐Huei Tsai

Nature Neuroscience, Год журнала: 2023, Номер 26(2), С. 181 - 195

Опубликована: Янв. 2, 2023

Язык: Английский

Процитировано

104
Lipid-accumulated reactive astrocytes promote disease progression in epilepsy DOI
Zhang‐Peng Chen,

Suji Wang,

Xiansen Zhao

и другие.

Nature Neuroscience, Год журнала: 2023, Номер 26(4), С. 542 - 554

Опубликована: Март 20, 2023

Язык: Английский

Процитировано

102
Adult hippocampal neurogenesis in Alzheimer’s disease: A roadmap to clinical relevance DOI Creative Commons
Evgenia Salta, Orly Lazarov, Carlos P. Fitzsimons

и другие.

Cell stem cell, Год журнала: 2023, Номер 30(2), С. 120 - 136

Опубликована: Фев. 1, 2023

Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients. Understanding AHN regulation could provide a framework for innovative pharmacological interventions. We here combine molecular, behavioral, clinical data critically discuss the multicellular complexity niche relation to pathophysiology. further present roadmap toward better understanding role by probing promises caveats latest technological advancements field addressing conceptual methodological challenges ahead.

Язык: Английский

Процитировано

82
Automatic cell-type harmonization and integration across Human Cell Atlas datasets DOI Creative Commons
Chuan Xu, Martin Prete, Simone Webb

и другие.

Cell, Год журнала: 2023, Номер 186(26), С. 5876 - 5891.e20

Опубликована: Дек. 1, 2023

Harmonizing cell types across the single-cell community and assembling them into a common framework is central to building standardized Human Cell Atlas. Here, we present CellHint, predictive clustering tree-based tool resolve cell-type differences in annotation resolution technical biases datasets. CellHint accurately quantifies cell-cell transcriptomic similarities places relationship graph that hierarchically defines shared unique subtypes. Application multiple immune datasets recapitulates expert-curated annotations. also reveals underexplored relationships between healthy diseased lung states eight diseases. Furthermore, workflow for fast cross-dataset integration guided by harmonized hierarchy, which uncovers underappreciated adult human hippocampus. Finally, apply 12 tissues from 38 datasets, providing deeply curated cross-tissue database with ∼3.7 million cells various machine learning models automatic tissues.

Язык: Английский

Процитировано

77
The Neuropsychology of Anxiety DOI
Neil McNaughton,

Jeffrey A. Gray

Oxford University Press eBooks, Год журнала: 2024, Номер unknown

Опубликована: Май 7, 2024

Abstract The Neuropsychology of Anxiety first appeared in 1982 as the volume Oxford Psychology Series, and it quickly established itself classic work on subject. It second edition (appearing 2000) have been cited at a steadily increasing rate passing 500/year 2017. field has continued to expand last quarter century necessitating this third edition. This completely updated revised (with many figures converted colour) retains original core concepts while expanding often simplifying details. includes new chapter prefrontal cortex, which integrates frontal hippocampal views anxiety an extensively modified personality providing basis for further developments Reinforcement Sensitivity Theory. book is essential postgraduate students researchers experimental psychology neuroscience, well all clinical psychologists psychiatrists.

Язык: Английский

Процитировано

74