Wild‐type MECP2 expression coincides with age‐dependent sensory phenotypes in a female mouse model for Rett syndrome

Journal of Neuroscience Research, Год журнала: 2023, Номер 101(8), С. 1236 - 1258

Опубликована: Апрель 7, 2023

Abstract Rett syndrome is characterized by an early period of typical development and then, regression learned motor speech skills in girls. Loss MECP2 protein thought to cause phenotypes. The specific underlying mechanisms from developmental trajectory features throughout life are unclear. Lack established timelines study the molecular, cellular, behavioral female mouse models a major contributing factor. Due random X‐chromosome inactivation, patients with for ( Mecp2 Heterozygous , Het) express functional copy wild‐type approximately half all cells. As expression regulated during postnatal experience, we primary somatosensory cortex Het mice. Here, report increased levels non‐parvalbumin‐positive neurons 6‐week‐old adolescent relative age‐matched controls, while also displaying perineuronal net barrel field subregion cortex, mild tactile sensory perception deficits, efficient pup retrieval behavior. In contrast, 12‐week‐old adult at similar mice, show display significant deficits. Thus, have identified set metrics cellular substrates time model, which coincides changes expression. We speculate that precocious increase within cell types may provide compensatory benefits level, inability further leads regressive phenotypes over time.

Язык: Английский

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Identification of touch neurons underlying dopaminergic pleasurable touch and sexual receptivity

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2021, Номер unknown

Опубликована: Сен. 22, 2021

Abstract Pleasurable touch during social behavior is the key to building familial bonds and meaningful connections. One form of occurs sexual encounters. Although initiated in part by touch, ongoing throughout copulation, identity role sensory neurons that transduce remain unknown. A population labeled G-protein coupled receptor Mrgprb4 detect stroking mice, however, these have never been implicated any natural behaviors. Here, we study relevance Mrgprb4-lineage genetically engineering mice allow activation or ablation this reveal are required for receptivity sufficient induce dopamine release brain. Even isolation, optogenetic stimulation through back skin a conditioned place preference striking dorsiflexion resembling lordotic copulatory posture females. In absence neurons, female no longer find male mounts rewarding: supplanted aggression coincident decline dopaminergic mesolimbic reward pathway. addition behavior, also postures induced female-to-female touch. Together, findings establish first skin-to-brain circuit encoding rewarding quality

Язык: Английский

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A detailed behavioral, videographic, and neural dataset on object recognition in mice

Scientific Data, Год журнала: 2022, Номер 9(1)

Опубликована: Окт. 13, 2022

Abstract Mice adeptly use their whiskers to touch, recognize, and learn about objects in environment. This behavior is enabled by computations performed populations of neurons the somatosensory cortex. To understand these computations, we trained mice recognize different shapes while recorded activity barrel cortex, which processes whisker input. Here, present a large dataset high-speed video whiskers, along with rigorous tracking entire extent multiple every contact they made on shape. We used spike sorting identify individual neurons, responded precise timing contacts motion. These data will be useful for understanding behavioral strategies explore objects, as well neuronal dynamics that mediate those strategies. In addition, our carefully curated labeled could develop new computer vision algorithms body posture, or extracting responses from large-scale neural recordings.

Язык: Английский

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Remembrance of things perceived: Adding thalamocortical function to artificial neural networks

Frontiers in Integrative Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Март 7, 2023

Recent research has illuminated the complexity and importance of thalamocortical system but it been difficult to identify what computational functions performs. Meanwhile, deep-learning artificial neural networks (ANNs) based on bio-inspired models purely cortical circuits have achieved surprising success solving sophisticated cognitive problems associated historically with human intelligence. Nevertheless, limitations shortcomings intelligence (AI) such ANNs are becoming increasingly clear. This review considers how addition connectivity its putative related attention might address some those shortcomings. Such now providing both testable theories biological cognition improved AI technology, much which is happening outside usual academic venues.

Язык: Английский

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A collicular map for touch-guided tongue control

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

Abstract Accurate goal-directed behavior requires the sense of touch to be integrated with information about body position and ongoing motion 1,2,3 . Behaviors like chewing, swallowing speech critically depend on precise tactile events a rapidly moving tongue 4,5 , but neural circuits for dynamic touch-guided control are unknown. Using high speed videography, we examined 3D lingual kinematics as mice drank from water spout that unexpectedly changed during licking, requiring re-aiming in response subtle contact left, center or right surface tongue. Mice both re-aim ensuing licks. Surprisingly, was unaffected by photoinactivation sensory, premotor motor cortices, impaired lateral superior colliculus (latSC). Electrophysiological recordings identified latSC neurons mechanosensory receptive fields were anchored tongue-centered, head-centered conjunctive reference frames. Notably, also encoded before contact, important tongue-to-head based coordinate transformations underlying accurate aiming. Viral tracing revealed sensory inputs trigeminal nucleus, optical microstimulation topographic map aiming These findings demonstrate first time relies collicular mechanosensorimotor map, analogous visuomotor maps associated visually-guided orienting across many species.

Язык: Английский

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