Molecular Neurobiology,
Год журнала:
2022,
Номер
60(3), С. 1369 - 1390
Опубликована: Ноя. 29, 2022
Abstract
Sepsis
is
a
leading
cause
of
intensive
care
unit
admission
and
death
worldwide.
Most
surviving
patients
show
acute
or
chronic
mental
disorders,
which
are
known
as
sepsis-associated
encephalopathy
(SAE).
Although
accumulating
studies
in
the
past
two
decades
focused
on
pathogenesis
SAE,
systematic
review
retrospective
exclusively
focuses
inflammatory
mechanisms
SAE
has
been
lacking
yet.
This
summarizes
recent
advance
field
neuroinflammation
sheds
light
activation
microglia
SAE.
Activation
predominates
neuroinflammation.
As
gene
expression
profile
changes,
heterogeneous
characterizations
throughout
all
stages
Here,
we
summarize
systemic
inflammation
following
sepsis
also
relationship
microglial
diversity
Moreover,
collection
neuroinflammation-related
dysfunction
reviewed
to
illustrate
possible
for
In
addition,
promising
pharmacological
non-pharmacological
therapeutic
strategies,
especially
those
target
microglia,
concluded
final
part
this
review.
Collectively,
clarification
vital
between
SAE-related
disorders
would
significantly
improve
our
understanding
pathophysiological
therefore
provide
potential
targets
therapies
aimed
at
inhibiting
Current Opinion in Neurobiology,
Год журнала:
2022,
Номер
78, С. 102652 - 102652
Опубликована: Дек. 1, 2022
There
is
growing
appreciation
of
key
roles
the
gut
microbiota
in
maintaining
homeostasis
and
influencing
brain
behaviour
at
critical
windows
across
lifespan.
Mounting
evidence
suggests
that
communication
between
could
be
to
understanding
multiple
neuropsychiatric
disorders,
with
immune
system
coming
forefront
as
an
important
mechanistic
mediator.
Throughout
lifespan,
exchanges
continuous
reciprocal
signals
central
nervous
system.
Intestinal
microbial
cues
alter
mediators
consequences
for
host
neurophysiology
behaviour.
Several
factors
challenge
composition,
which
response
release
molecules
neuro-
immuno-active
potential
are
crucial
adequate
neuro-immune
interactions.
In
this
review,
contributing
upkeep
fine
balance
health
disease
these
systems
discussed,
we
elucidate
implications
inputs
on
European journal of medical research,
Год журнала:
2022,
Номер
27(1)
Опубликована: Май 25, 2022
Stroke
is
a
type
of
cerebrovascular
disease
that
significantly
endangers
human
health
and
lowers
quality
life.
This
understandably
places
heavy
burden
on
society
families.
In
recent
years,
intestinal
flora
has
attracted
increasing
attention
from
scholars
worldwide,
its
association
with
ischemic
stroke
becoming
hot
topic
research
amongst
researchers
in
field
stroke.
After
suffering
stroke,
microbial
dysbiosis
leads
to
increased
permeability
activation
the
immune
system,
which
turn
ectopic
bacteria
pro-inflammatory
cells
enter
brain
tissue
through
damaged
blood-brain
barrier.
exacerbates
ischemia-reperfusion
injury.
Interestingly,
after
some
metabolites
produced
by
attenuate
injury
suppressing
post-stroke
inflammatory
response
promotes
repair
neurological
function.
Here
we
elucidate
changes
gut
occurrence
highlight
immunomodulatory
processes
flora.
Theranostics,
Год журнала:
2022,
Номер
12(8), С. 3637 - 3655
Опубликована: Янв. 1, 2022
The
high
fat
and
sucrose
diet,
known
as
the
obesogenic
diet
(OD),
has
been
related
to
low-grade
chronic
inflammation
neurodevelopmental
disorders.
Emerging
evidence
suggests
that
OD
influences
cognitive
social
function
via
gut-brain
axis.
However,
effects
of
during
adolescence
on
future
health
have
unclear.
Meanwhile,
underlying
mechanisms
effective
interventions
are
not
fully
understood.
Polysaccharides,
one
most
abundant
substances
in
Frontiers in Aging Neuroscience,
Год журнала:
2022,
Номер
14
Опубликована: Авг. 3, 2022
Phosphatidylserine
(PS)
is
an
anionic
phospholipid
in
the
eukaryotic
membrane
and
abundant
brain.
Accumulated
studies
have
revealed
that
PS
involved
multiple
functions
of
brain,
such
as
activation
signaling
pathways,
neuroinflammation,
neurotransmission,
synaptic
refinement.
Those
are
related
to
central
nervous
system
(CNS)
diseases.
In
this
review,
we
discuss
metabolism
PS,
anti-inflammation
function
brain;
alterations
different
CNS
diseases,
possibility
serve
a
therapeutic
agent
for
Clinical
showed
has
no
side
effects
well
tolerated.
Therefore,
liposome
could
be
promising
supplementation
these
neurodegenerative
neurodevelopmental
Molecular Neurobiology,
Год журнала:
2022,
Номер
60(3), С. 1369 - 1390
Опубликована: Ноя. 29, 2022
Abstract
Sepsis
is
a
leading
cause
of
intensive
care
unit
admission
and
death
worldwide.
Most
surviving
patients
show
acute
or
chronic
mental
disorders,
which
are
known
as
sepsis-associated
encephalopathy
(SAE).
Although
accumulating
studies
in
the
past
two
decades
focused
on
pathogenesis
SAE,
systematic
review
retrospective
exclusively
focuses
inflammatory
mechanisms
SAE
has
been
lacking
yet.
This
summarizes
recent
advance
field
neuroinflammation
sheds
light
activation
microglia
SAE.
Activation
predominates
neuroinflammation.
As
gene
expression
profile
changes,
heterogeneous
characterizations
throughout
all
stages
Here,
we
summarize
systemic
inflammation
following
sepsis
also
relationship
microglial
diversity
Moreover,
collection
neuroinflammation-related
dysfunction
reviewed
to
illustrate
possible
for
In
addition,
promising
pharmacological
non-pharmacological
therapeutic
strategies,
especially
those
target
microglia,
concluded
final
part
this
review.
Collectively,
clarification
vital
between
SAE-related
disorders
would
significantly
improve
our
understanding
pathophysiological
therefore
provide
potential
targets
therapies
aimed
at
inhibiting
