Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration DOI Creative Commons
Philip R. Williams, Zhao‐Weng Wang,

Chengzhi Zhao

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Neuronal function requires high energy expenditure that is likely customized to meet specific signaling demands. However, little known about diversity of metabolic homeostasis among divergently-functioning types neurons. To this end, we examined retinal ganglion cells (RGCs), a population closely related, yet electrophysiologically distinct excitatory projection Using in vivo 2-photon imaging measure ATP with single cell resolution, identified differential homeostatic maintenance the RGC correspond types. In presence circuit activity, most active type (Alpha RGCs), had lower levels than other and exhibited greatest magnitude decline when synthesis was inhibited. By simultaneously manipulating activity mitochondrial function, found while oxidative phosphorylation required demands during it expendable maintain resting levels. We also signatures associated survival injury response after axotomy report correlation between low increased survival. addition, observed transient increases RGCs following axon injury. Together, these findings identify handling capabilities dynamically neurons implications for neuronal resilience.

Язык: Английский

Brain histone beta-hydroxybutyrylation couples metabolism with gene expression DOI
Sara Cornuti, Siwei Chen, Leonardo Lupori

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2023, Номер 80(1)

Опубликована: Янв. 1, 2023

Язык: Английский

Процитировано

15
How astrocytic ATP shapes neuronal activity and brain circuits DOI Creative Commons
Jonathan Lezmy

Current Opinion in Neurobiology, Год журнала: 2023, Номер 79, С. 102685 - 102685

Опубликована: Фев. 4, 2023

Astrocytes play a key role in processing information at synapses, by controlling synapse formation, modulating strength and terminating neurotransmitter action. They release ATP to shape brain activity but it is unclear how, as astrocyte processes contact many targets ATP-mediated effects are diverse numerous. Here, I review recent studies showing how astrocytic modulates cellular mechanisms nearby neurons glia the grey white matter, affects signal transmission these areas, behavioural outputs. attempt provide flowchart of signalling, that tends inhibit neural circuits match energy demands.

Язык: Английский

Процитировано

14
The Astrocyte: Metabolic Hub of the Brain DOI
L. Felipe Barros, Stefanie Schirmeier, Bruno Weber

и другие.

Cold Spring Harbor Perspectives in Biology, Год журнала: 2024, Номер 16(9), С. a041355 - a041355

Опубликована: Март 4, 2024

Astrocytic metabolism has taken center stage. Interposed between the neuron and vasculature, astrocytes exert control over fluxes of energy building blocks required for neuronal activity plasticity. They are also key to local detoxification waste recycling. Whereas neurons metabolically rigid, can switch different metabolic profiles according demand nutritional state organism. Their even seems be instructive peripheral nutrient mobilization been implicated in information processing behavior. Here, we summarize recent progress our understanding astrocytic its effects on homeostasis cognition.

Язык: Английский

Процитировано

6
Pareto optimality, economy–effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons DOI Creative Commons
Peter Jedlička, Alex D. Bird, Hermann Cuntz

и другие.

Open Biology, Год журнала: 2022, Номер 12(7)

Опубликована: Июль 1, 2022

Neurons encounter unavoidable evolutionary trade-offs between multiple tasks. They must consume as little energy possible while effectively fulfilling their functions. Cells displaying the best performance for such multi-task are said to be Pareto optimal, with ion channel configurations underpinning functionality. Ion degeneracy, however, implies that can lead functionally similar behaviour. Therefore, instead of a single model, neuroscientists often use populations models distinct combinations ionic conductances. This approach is called population (database or ensemble) modelling. It remains unclear, which parameters in vast functional more likely found brain. Here we argue optimality serve guiding principle addressing this issue by helping identify subpopulations conductance-based perform trade-off economy and In way, high-dimensional parameter space neuronal might reduced geometrically simple low-dimensional manifolds, potentially explaining experimentally observed correlations. Conversely, inference also help deduce functions from Patch-seq data. summary, promising framework improving modelling neurons circuits.

Язык: Английский

Процитировано

21
Bio-Inspired Design of Superconducting Spiking Neuron and Synapse DOI Creative Commons
Andrey E. Schegolev, N. V. Klenov, Georgy I. Gubochkin

и другие.

Nanomaterials, Год журнала: 2023, Номер 13(14), С. 2101 - 2101

Опубликована: Июль 19, 2023

The imitative modelling of processes in the brain living beings is an ambitious task. However, advances complexity existing hardware models are limited by their low speed and high energy consumption. A superconducting circuit with Josephson junctions closely mimics neuronal membrane channels involved operation sodium-potassium pump. dynamic such a system characterised duration picoseconds level attojoules. In this work, two biological neuron studied. New modes identified, including so-called bursting mode, which plays important role neural networks. possibility switching between different situ shown, providing control system. synaptic connection that short-term potentiation synapse developed demonstrated. Finally, simplest two-neuron chain comprising proposed bio-inspired components simulated, prospects biosimilars briefly discussed.

Язык: Английский

Процитировано

12
Sex-dependent differences in animal cognition DOI Creative Commons
Aleksandra Koszałka, Klaudia Lustyk, Karolina Pytka

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 153, С. 105374 - 105374

Опубликована: Авг. 25, 2023

The differences in cognitive processes driven by biological sex are the issues that have gotten growing attention recently. Considering increasing population suffering from various impairments and development of therapeutic strategies, it is essential we recognize mechanisms responsible for discrepancies observed male female learning memory functions. In this review, discuss recent reports preclinical studies on rodents regarding selected domains to state knowledge sex-dependent point challenges encountered during such research. We focus spatial, recognition, emotional memory, as well executive functions, attention, flexibility, working memory. This review will help acknowledge sex-related cognition indicate some fields lack sufficient data.

Язык: Английский

Процитировано

12
Recent Advances at the Interface of Neuroscience and Artificial Neural Networks DOI Creative Commons
Yarden Cohen, Tatiana A. Engel, Christopher Langdon

и другие.

Journal of Neuroscience, Год журнала: 2022, Номер 42(45), С. 8514 - 8523

Опубликована: Ноя. 9, 2022

Biological neural networks adapt and learn in diverse behavioral contexts. Artificial (ANNs) have exploited biological properties to solve complex problems. However, despite their effectiveness for specific tasks, ANNs are yet realize the flexibility adaptability of cognition. This review highlights recent advances computational experimental research advance our understanding artificial intelligence. In particular, we discuss critical mechanisms from cellular, systems, cognitive neuroscience fields that contributed refining architecture training algorithms ANNs. Additionally, how work used understand neuronal correlates cognition process high throughput data.

Язык: Английский

Процитировано

19
Rational inattention in mice DOI Creative Commons
Nikola Grujic, Jeroen Brus, Denis Burdakov

и другие.

Science Advances, Год журнала: 2022, Номер 8(9)

Опубликована: Март 4, 2022

Behavior exhibited by humans and other organisms is generally inconsistent biased and, thus, often labeled irrational. However, the origins of this seemingly suboptimal behavior remain elusive. We developed a behavioral task normative framework to reveal how should allocate their limited processing resources such that sensory precision its related metabolic investment are balanced guarantee maximal utility. found mice act as rational inattentive agents adaptively allocating in way maximizes reward consumption previously unexperienced stimulus-reward association environments. Unexpectedly, perception commonly occurring stimuli was relatively imprecise; however, apparent statistical fallacy implies “awareness” efficient adaptation neurocognitive limitations. Arousal systems carry distribution information signals, distributional reinforcement learning mechanisms regulate via top-down normalization. These findings efficiently perceive adapt environmental contexts within constraints imposed neurobiology.

Язык: Английский

Процитировано

18
Mitochondrial Ca2+ uniporter haploinsufficiency enhances long-term potentiation at hippocampal mossy fibre synapses DOI Creative Commons
Michael J. Devine,

Blanka R. Szulc,

Jack H. Howden

и другие.

Journal of Cell Science, Год журнала: 2022, Номер 135(22)

Опубликована: Окт. 24, 2022

ABSTRACT Long-term changes in synaptic strength form the basis of learning and memory. These rely upon energy-demanding mechanisms, which are regulated by local Ca2+ signalling. Mitochondria optimised for providing energy buffering Ca2+. However, our understanding role mitochondria regulating plasticity is incomplete. Here, we have used optical electrophysiological techniques cultured hippocampal neurons ex vivo slices from mice with haploinsufficiency mitochondrial uniporter (MCU+/−) to address whether reducing uptake alters transmission plasticity. We found that MCU+/− impaired clearance, consequently enhanced vesicle fusion at presynapses occupied mitochondria. Furthermore, long-term potentiation (LTP) mossy fibre (MF) synapses, a process dependent on presynaptic accumulation, slices. Our results reveal previously unrecognised major excitatory pathway involved

Язык: Английский

Процитировано

18
DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting DOI Creative Commons
Christopher J. Yuskaitis,

Jinita B. Modasia,

Sandra Schrötter

и другие.

Cell Reports, Год журнала: 2022, Номер 40(9), С. 111278 - 111278

Опубликована: Авг. 1, 2022

Caloric restriction and acute fasting are known to reduce seizures but through unclear mechanisms. mTOR signaling has been suggested as a potential mechanism for seizure protection from fasting. We demonstrate that brain mTORC1 is reduced after of mice neuronal integrates GATOR1 complex-mediated amino acid tuberous sclerosis complex (TSC)-mediated growth factor signaling. Neuronal most sensitive withdrawal leucine, arginine, glutamine, which dependent on DEPDC5, component the complex. Metabolomic analysis reveals Depdc5 neuronal-specific knockout resistant sensing significant fluctuations in levels protective effects or seizure-induced death. These results establish reduces susceptibility DEPDC5-dependent manner. Modulation nutrients upstream could offer rational therapeutic strategy epilepsy treatment.

Язык: Английский

Процитировано

16