The
claustrum
(CLA),
a
subcortical
nucleus
in
mammals,
essentially
composed
of
excitatory
projection
neurons
and
known
for
its
extensive
connections
with
the
neocortex,
has
recently
been
associated
variety
functions
ranging
from
consciousness
to
impulse
control.
However,
research
on
CLA
challenging
due
difficulties
specifically
comprehensively
targeting
neuronal
populations.
In
various
cases,
this
limitation
led
inconsistent
findings
lack
reliable
data.
present
work,
we
describe
expression
profile
Smim32
gene,
which
is
almost
exclusively
transcribed
endopiriform
nucleus,
as
well
inhibitory
thalamic
reticular
nucleus.
Leveraging
unique
pattern,
developed
series
Cre-
Flippase-expressing
knockin
BAC
transgenic
mouse
lines
different
profiles.
With
these
novel
tools
hand,
propose
new
standards
interrogation
function.
Cell Reports,
Год журнала:
2022,
Номер
41(4), С. 111534 - 111534
Опубликована: Окт. 1, 2022
Behavioral
flexibility
is
the
ability
to
adjust
behavioral
strategies
in
response
changing
environmental
contingencies.
A
major
hypothesis
field
posits
that
activity
of
neurons
locus
coeruleus
(LC)
plays
an
important
role
mediating
flexibility.
To
test
this
hypothesis,
we
developed
a
tactile-based
rule-shift
detection
task
which
mice
responded
left
and
right
whisker
deflections
context-dependent
manner
exhibited
varying
degrees
switching
behavior.
Recording
spiking
from
optogenetically
tagged
LC
at
millisecond
precision
during
performance
revealed
prominent
graded
correlation
between
baseline
flexibility,
where
higher
following
rule
change
was
associated
with
faster
new
rule.
Increasing
optogenetic
activation
accelerated
improved
performance.
Overall,
our
study
provides
evidence
reveal
link
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
155, С. 105475 - 105475
Опубликована: Ноя. 22, 2023
The
brain
is
a
remarkably
complex
organ
responsible
for
wide
range
of
functions,
including
the
modulation
emotional
states
and
movement.
Neuronal
circuits
are
believed
to
play
crucial
role
in
integrating
sensory,
cognitive,
information
ultimately
guide
motor
behavior.
Over
years,
numerous
studies
employing
diverse
techniques
such
as
electrophysiology,
imaging,
optogenetics
have
revealed
network
neural
involved
regulation
or
processes.
Emotions
can
exert
substantial
influence
on
performance,
encompassing
both
everyday
activities
pathological
conditions.
aim
this
review
explore
how
shape
movements
by
connecting
processing
circuits.
We
first
provide
comprehensive
overview
impact
different
control
humans
rodents.
In
line
with
behavioral
studies,
we
set
out
identify
emotion-related
structures
capable
modulating
output,
behaviorally
anatomically.
extensively
connected
system.
These
drive
behavior,
essential
survival,
but
also
continuously
ongoing
summary,
investigation
intricate
relationship
between
emotion
movement
offers
valuable
insights
into
human
opportunities
enhance
holds
promise
improving
mental
physical
health.
This
integrates
findings
from
multiple
scientific
approaches,
anatomical
tracing,
circuit-based
dissection,
conducted
animal
subjects.
By
incorporating
these
methodologies,
present
current
understanding
physiological
Cell Reports,
Год журнала:
2024,
Номер
43(4), С. 113991 - 113991
Опубликована: Апрель 1, 2024
The
brain
receives
constant
tactile
input,
but
only
a
subset
guides
ongoing
behavior.
Actions
associated
with
stimuli
thus
endow
them
behavioral
relevance.
It
remains
unclear
how
the
relevance
of
affects
processing
in
somatosensory
(S1)
cortex.
We
developed
cross-modal
selection
task
which
head-fixed
mice
switched
between
responding
to
presence
visual
distractors
or
using
licking
movements
left
right
side
different
blocks
trials.
S1
spiking
encoded
stimuli,
actions,
and
direction
response
not
stimuli.
Bidirectional
optogenetic
manipulations
showed
that
sensory-motor
activity
guided
behavior
when
touch
vision
was
relevant.
Our
results
show
its
impact
on
depend
actions
stimulus.
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0318307 - e0318307
Опубликована: Фев. 11, 2025
We
have
recently
identified
a
group
of
claustral
neurons
that
continuously
maintain
information
associated
with
fear-conditioned
stimulus
(CS)
for
at
least
tens
seconds,
even
after
the
CS
has
ceased.
This
“online
state”
refers
to
persistent
maintenance
threat-associated
information,
enabling
it
be
actively
processed
threat
terminated.
state
may
involve
reciprocal
interactions
brain
regions
involved
in
decision-making,
motor
preparation,
and
adaptive
behavioral
responses.
If
these
truly
encode
online
state,
their
function
should
remain
independent
modality
or
specific
defensive
behavior
exhibited.
In
this
study,
we
used
tone
cue
monitored
freezing
trace
conditioning,
contrast
light
escape
our
recent
study.
During
retrieval
test
subset
rostral-to-striatum
claustrum
(rsCla)
exhibited
sustained
activity
response
CS,
particularly
during
interval.
Importantly,
found
positive
correlation
between
rsCla
magnitude
interval,
when
intervals
without
were
excluded.
Thus,
appears
exhibit
characteristics
‘online
neurons’
memory
following
conditioning.
Cerebral Cortex,
Год журнала:
2022,
Номер
33(7), С. 3944 - 3959
Опубликована: Сен. 14, 2022
Abstract
The
claustrum
is
known
for
its
extensive
connectivity
with
many
other
forebrain
regions,
but
elongated
shape
and
deep
location
have
made
further
study
difficult.
We
sought
to
understand
when
mouse
neurons
are
born,
where
they
located
in
developing
brains,
develop
their
widespread
connections
the
cortex.
established
that
a
well-characterized
parvalbumin
plexus,
which
identifies
adults,
only
present
from
postnatal
day
(P)
21.
A
myeloarchitectonic
outline
of
can
be
derived
triangular
fiber
arrangement
P15.
dense
patch
Nurr1+
cells
at
core
already
evident
birth.
Bromodeoxyuridine
birth
dating
progenitors
reveals
majority
born
during
narrow
time
window
centered
on
embryonic
12.5,
later
than
adjacent
subplate
endopiriform
nucleus.
Retrograde
tracing
revealed
projections
anterior
cingulate
(ACA)
retrosplenial
cortex
(RSP)
follow
distinct
developmental
trajectories.
Claustrum–ACA
matures
rapidly
reaches
adult-like
innervation
density
by
P10,
whereas
claustrum–RSP
emerges
over
protracted
window.
This
work
establishes
timeline
development
provides
framework
understanding
how
built
develops
unique
connectivity.
Frontiers in Aging Neuroscience,
Год журнала:
2023,
Номер
15
Опубликована: Апрель 14, 2023
Alzheimer’s
disease
(AD)
is
one
of
the
most
common
neurodegenerative
diseases
characterized
by
cognitive
deficits
and
dementia.
AD
entails
predominant
pathological
characteristics
including
amyloid
beta
(Aβ)
plaque
formation,
neurofibrillary
entanglements,
brain
atrophy,
which
gradually
result
in
dysfunctions.
Studies
showed
that
these
changes
are
found
a
myriad
structures,
claustrum
(CLA),
nucleus
penetrates
deeply
into
extensively
interconnected
to
various
structures.
The
CLA
modulates
many
aspects
functions,
with
attention,
executive
function,
visuospatial
ability,
language,
memory
particular.
It
also
implicated
multiple
neuropsychiatric
disorders,
worthy
particular
attention
AD-related
impairments.
To
inspire
novel
treatment
strategies,
this
review
has
summarized
functionality
discriminative
dysfunctions
AD.
And
then
propose
an
array
potential
mechanisms
might
contribute
impairments
caused
abnormal
physiology.
We
advocate
be
new
promising
therapeutic
target
combination
existing
anti-AD
drugs
stimulation
approaches
for
future
treatment.
Cell Reports,
Год журнала:
2024,
Номер
43(2), С. 113748 - 113748
Опубликована: Фев. 1, 2024
Animals
are
known
to
exhibit
innate
and
learned
forms
of
defensive
behaviors,
but
it
is
unclear
whether
animals
can
escape
through
methods
other
than
these
forms.
In
this
study,
we
develop
the
delayed
task,
in
which
male
rats
temporarily
hold
information
required
for
future
escape,
demonstrate
that
subject
extrapolates
from
past
experience
without
direct
its
behavioral
outcome,
does
not
fall
into
either
two
behavior.
During
holding
period,
a
subset
neurons
rostral-to-striatum
claustrum
(rsCla),
only
when
pooled
together,
sustain
enhanced
population
activity
ongoing
sensory
stimuli.
Transient
inhibition
rsCla
during
initial
part
period
produces
prolonged
activity.
The
transient
also
attenuates
Our
data
suggest
bridges
escape-inducing
stimuli
onset
escape.
Brain Structure and Function,
Год журнала:
2024,
Номер
229(5), С. 1143 - 1164
Опубликована: Апрель 14, 2024
Abstract
The
claustrum
is
an
ancient
telencephalic
subcortical
structure
displaying
extensive,
reciprocal
connections
with
much
of
the
cortex
and
receiving
projections
from
thalamus,
amygdala,
hippocampus.
This
has
a
general
role
in
modulating
cortical
excitability
considered
to
be
engaged
different
cognitive
motor
functions,
such
as
sensory
integration
perceptual
binding,
salience-guided
attention,
top-down
executive
well
control
brain
states,
sleep
its
interhemispheric
integration.
present
study
first
describe
detail
projection
striatum
macaque
brain.
Based
on
tracer
injections
striatal
regions
areas,
we
observed
rough
topography
claustral
connectivity,
thanks
which
zone
projects
both
specific
territory
areas
involved
network
projecting
same
territory.
data
add
new
elements
complexity
basal
ganglia
information
processing
mode
non-motor
functions
provide
evidence
for
influence
functional
domains
cortico-basal
circuits.
