Genotypic sex shapes maternal care in the African pygmy mouse, Mus minutoides DOI
Louise D. Heitzmann,

Marie Challe,

Julie Pérez

и другие.

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 290(2006)

Опубликована: Сен. 6, 2023

Sexually dimorphic behaviours, such as parental care, have long been thought to be mainly driven by gonadal hormones. In the past two decades, a few studies challenged this view, highlighting direct influence of sex chromosome complement (XX versus XY or ZZ ZW). The African pygmy mouse, Mus minutoides , is wild mouse species with naturally occurring reversal induced third, feminizing X* chromosome, leading three female genotypes: XX, XX* and X*Y. Here, we show that in X*Y females shapes divergent maternal care strategy (maternal aggression, pup retrieval nesting behaviours) from both XX females. Although neuroanatomical investigations were inconclusive, dopaminergic system anteroventral periventricular nucleus hypothalamus worth investigating further it may support differences behaviour between Combining behaviours neurobiology rodent subject natural selection, evaluate potential candidates for neural basis strengthen underestimated role chromosomes shaping brain behaviours. All things considered, highlight emergence third sexual phenotype, challenging binary view phenotypic sexes.

Язык: Английский

A new insight into the role of CART peptide in serotonergic function and anxiety DOI Open Access
Nagalakshmi Balasubramanian, Ruixiang Wang,

Shafa Ismail

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 22, 2024

Abstract Cocaine and amphetamine-regulated transcript (CART) peptide has been established as a contributor to anxiogenic behavior. Genetic mutations in the CART gene are associated with anxiety depression, increased expression reported suicide victims. Extensive research focused on role of mesolimbic neurocircuitry, but its involvement dorsal raphe nucleus (DRN) serotonin (5HT) system remains unexplored. Here we demonstrate that processes proximal 5HT DRN neurons microinjection (55-102) into an effect mice. Furthermore, central administration reduced cfos activation ventral DRN, which is putative reward/anti-stress circuit. The inhibitory neuronal function local release further demonstrated vivo fiber photometry coupled calcium biosensors by mass spectrometry. Moreover, using Cre-dependent retrograde tracing, observed DRN-projecting Edinger Westphal (EW), accumbens (NAc), various hypothalamic nuclei including ventromedial hypothalamus (VMH). Interestingly, based ex electrophysiological recordings, acute stress excitability located EW, not VMH or NAc. This suggests may promote anxiety-like behavior activating EW →5HT circuit ultimately inhibits transmission. In sum, understanding intricate dynamics CARTergic 5HTergic systems proves crucial addressing 5HT-related dysfunctions, providing invaluable insights both health disease.

Язык: Английский

Процитировано

1
Edinger-Westphal ghrelin receptor signalling regulates binge alcohol consumption in a sex specific manner DOI Creative Commons

Amy Pearl,

Paulo Pinares-Garcia,

Arnav Shesham

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 27, 2024

Abstract Background Rates of risky drinking are continuing to rise, particularly in women, yet sex as a biological variable has been largely ignored. An emerging understudied potential component this circuitry is the central projecting Edinger-Westphal (EWcp), which made up two prominent, but distinct cell populations expressing either an array neuropeptides (including cocaine and amphetamine regulated transcript; CART) or vGlut2 (glutamatergic). Methods Here, we use combination approaches including genetic, molecular biology, behavioural testing, electrophysiology understand how EWcp contributes alcohol consumption female versus male mice. Results Chemogenetic inhibition CART cells reduced binge specifically female, not Further, prevented ghrelin induced drinking, viral–mediated receptor ( Ghsr ) knockdown RNAscope revealed expression across peptidergic (marked by glutamatergic EWcp, with neurons from mice more sensitive bath application than Targeted GHSR signalling on peptidergic, mediate Finally, both inverse agonist antagonist delivered directly within Conclusions These findings suggest region mediating excessive bingeing through actions (CART-expressing) expand our understanding neural mechanism(s) underpinning system mediates consumption.

Язык: Английский

Процитировано

1
The Neurobiology of Parenting and Infant-Evoked Aggression DOI
Harris S. Kaplan, Patricia M. Horvath, Mohammed Mostafizur Rahman

и другие.

Physiological Reviews, Год журнала: 2024, Номер 105(1), С. 315 - 381

Опубликована: Авг. 15, 2024

Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization individual priorities physiology is facilitated by combinatorial hormone action on specific cell types that are integrated throughout interconnected brainwide neuronal circuits. In this review, we take comprehensive approach integrate historical current literature each these topics species, with focus rodents. New emerging molecular, circuit-based, computational technologies have recently been used address outstanding gaps in our framework knowledge infant-directed behavior. This work raising fundamental questions about the interplay between instinctive learned components parenting mutual regulation affiliative versus agonistic behaviors health disease. Whenever possible, point how helped gain novel insights opened new avenues research into neurobiology parenting. We hope review will serve as introduction for those field, resource already studying parenting, guidepost designing future studies.

Язык: Английский

Процитировано

1
Transient receptor potential ankyrin 1 ion channel expressed by the Edinger-Westphal nucleus contributes to stress adaptation in murine model of posttraumatic stress disorder DOI Creative Commons

János Konkoly,

Viktória Kormos, Balázs Gaszner

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10

Опубликована: Дек. 6, 2022

The centrally projecting Edinger-Westphal nucleus (EWcp) is involved in stress adaptation. Transient receptor potential ankyrin 1 (TRPA1) mRNA was previously shown to be expressed abundantly mouse and human EWcp urocortin (UCN1) positive neurons reacted chronic stress. Since UCN1 are deeply implicated stress-related disorders, we hypothesized that TRPA1/UCN1 also affected posttraumatic disorder (PTSD). We examined male

Язык: Английский

Процитировано

6
Genotypic sex shapes maternal care in the African pygmy mouse, Mus minutoides DOI
Louise D. Heitzmann,

Marie Challe,

Julie Pérez

и другие.

Proceedings of the Royal Society B Biological Sciences, Год журнала: 2023, Номер 290(2006)

Опубликована: Сен. 6, 2023

Sexually dimorphic behaviours, such as parental care, have long been thought to be mainly driven by gonadal hormones. In the past two decades, a few studies challenged this view, highlighting direct influence of sex chromosome complement (XX versus XY or ZZ ZW). The African pygmy mouse, Mus minutoides , is wild mouse species with naturally occurring reversal induced third, feminizing X* chromosome, leading three female genotypes: XX, XX* and X*Y. Here, we show that in X*Y females shapes divergent maternal care strategy (maternal aggression, pup retrieval nesting behaviours) from both XX females. Although neuroanatomical investigations were inconclusive, dopaminergic system anteroventral periventricular nucleus hypothalamus worth investigating further it may support differences behaviour between Combining behaviours neurobiology rodent subject natural selection, evaluate potential candidates for neural basis strengthen underestimated role chromosomes shaping brain behaviours. All things considered, highlight emergence third sexual phenotype, challenging binary view phenotypic sexes.

Язык: Английский

Процитировано

3