Theranostics,
Год журнала:
2025,
Номер
15(8), С. 3257 - 3274
Опубликована: Фев. 18, 2025
Rationale:
The
prelimbic
cortex
(PrL),
enriched
with
oxytocin
(OXT)
receptors,
plays
a
critical
role
in
memory
consolidation.
However,
the
of
OXT
social
consolidation
within
PrL
microcircuit
remains
poorly
understood.
Methods:
To
examine
signaling
consolidation,
we
used
biosensors
and
loss-of-function
approaches,
including
tetanus
toxin-mediated
silencing
neurons
paraventricular
nucleus
(PVNOXT),
optogenetic
inhibition
PVNOXT-PrL
pathway
during
rapid-eye-movement
(REM)
sleep,
local
administration
an
receptor
antagonist
PrL.
In
vivo
molecular
for
vasoactive
intestinal
peptide
(VIP),
somatostatin,
presynaptic
calcium
imaging
were
employed
to
assess
inhibitory
microcircuit.
Optogenetic
activation
intranasal
evaluate
resilience
chronic
sleep
deprivation-induced
deficits.
Results:
We
identified
that
REM-sleep
release
via
PVN
supports
deficiency
reduces
activity
VIP
parvalbumin
(PV)
neurons,
thereby
disrupting
balance
between
somatic
mediated
by
PV
dendritic
disinhibition
microcircuits
REM
sleep.
Chronic
deprivation
(SD)
disrupts
balance,
leading
pyramidal
neuron
hyperactivity
impairments.
Notably,
REM-sleep-specific
or
restores
rescues
deficits
SD
mice.
Conclusion:
Our
results
reveal
how
modulates
support
suggesting
potential
therapeutic
strategies
treating
sleep-related
disorders.
Progress in Neurobiology,
Год журнала:
2024,
Номер
238, С. 102636 - 102636
Опубликована: Июнь 2, 2024
We
develop
further
here
the
only
quantitative
theory
of
storage
information
in
hippocampal
episodic
memory
system
and
its
recall
back
to
neocortex.
The
is
upgraded
account
for
a
revolution
understanding
spatial
representations
primate,
including
human,
hippocampus,
that
go
beyond
place
where
individual
located,
location
being
viewed
scene.
This
fundamental
much
primate
navigation:
functions
supported
humans
by
pathways
build
'where'
view
feature
combinations
ventromedial
visual
cortical
stream,
separate
from
those
'what'
object
face
inferior
temporal
cortex,
reward
orbitofrontal
cortex.
Key
new
computational
developments
include
capacity
CA3
attractor
network
storing
whole
charts
space;
how
correlations
inherent
self-organizing
continuous
impact
capacity;
can
combine
discrete
representations;
roles
rewards
reach
hippocampus
later
consolidation
into
long-term
part
via
cholinergic
cortex;
ways
analysing
neocortical
using
Potts
networks.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Март 23, 2023
Abstract
Dopamine
has
a
significant
role
in
motor
and
cognitive
function.
The
dopaminergic
pathways
originating
from
the
midbrain
have
received
most
attention;
however,
relevance
of
cerebellar
system
is
largely
undiscovered.
Here,
we
show
that
major
astrocyte
type
Bergmann
glial
cells
express
D1
receptors.
can
be
synthesized
Purkinje
by
cytochrome
P450
released
an
activity-dependent
fashion.
We
demonstrate
activation
receptors
induces
membrane
depolarization
Ca
2+
release
internal
store.
These
astrocytic
activities
turn
modify
cell
output
altering
its
excitatory
inhibitory
synaptic
input.
Lastly,
conditional
knockout
results
decreased
locomotor
activity
impaired
social
activity.
contribute
to
understanding
molecular,
cellular,
circuit
mechanisms
underlying
dopamine
function
cerebellum,
revealing
critical
for
behavior.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Март 29, 2023
Mutation
or
deletion
of
the
SHANK3
gene,
which
encodes
a
synaptic
scaffolding
protein,
is
linked
to
autism
spectrum
disorder
and
Phelan-McDermid
syndrome,
conditions
associated
with
social
memory
impairments.
Shank3B
knockout
mice
also
exhibit
deficits.
The
CA2
region
hippocampus
integrates
numerous
inputs
sends
major
output
ventral
CA1
(vCA1).
Despite
finding
few
differences
in
excitatory
afferents
mice,
we
found
that
activation
neurons
as
well
CA2-vCA1
pathway
restored
recognition
function
wildtype
levels.
vCA1
neuronal
oscillations
have
been
memory,
but
observed
no
these
measures
between
mice.
However,
enhanced
theta
power
concurrent
behavioral
improvements.
These
findings
suggest
stimulating
adult
circuitry
mouse
model
neurodevelopmental
impairments
can
invoke
latent
function.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 26, 2024
Abstract
Social
recognition
is
crucial
for
survival
in
social
species,
and
necessary
group
living,
selective
reproduction,
pair
bonding,
dominance
hierarchies.
Mice
rats
are
the
most
commonly
used
animal
models
memory
research,
however
current
paradigms
do
not
account
complex
dynamics
they
exhibit
wild.
To
assess
range
of
memories
being
studied,
we
conducted
a
systematic
analysis
neuroscience
articles
testing
mice
published
within
past
two
decades
analyzed
their
methods.
Our
results
show
that
despite
these
rodent’s
rich
capabilities,
majority
papers
explore
short-term
familiarity
levels
with
minimal
exposure
between
subject
familiar
stimuli—a
narrow
type
memory.
We
have
identified
several
key
areas
currently
understudied
or
underrepresented:
kin
relationships,
mates,
ranks,
sex
variabilities,
effects
aging.
Additionally,
reporting
on
stimulus
variables
such
as
housing
history,
strain,
age,
limited,
which
may
impede
reproducibility.
Overall,
our
data
highlight
large
gaps
diversity
studied
mechanisms.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 5, 2024
Social
memory
impairment
is
a
key
symptom
of
many
brain
disorders,
but
its
underlying
mechanisms
remain
unclear.
Neuroligins
(NLGs)
are
family
cell
adhesion
molecules
essential
for
synapse
development
and
function
their
dysfunctions
linked
to
neurodevelopmental
neuropsychiatric
including
autism
schizophrenia.
Although
NLGs
extensively
studied
in
neurons,
role
glial
cells
poorly
understood.
Here
we
show
that
astrocytic
deletion
NLG3
the
ventral
hippocampus
adult
male
mice
impairs
social
memory,
attenuates
Ca
The
formation
of
new
social
interactions
is
vital
for
animals,
but
the
underlying
neural
mechanisms
remain
poorly
understood.
We
identified
CeA
Npbwr1
neurons,
a
population
in
central
amygdala
expressing
neuropeptide
B/W
receptor-1
(NPBWR1),
that
play
critical
role
these
interactions.
neurons
were
activated
during
encounters
with
unfamiliar,
not
familiar,
mice.
Manipulations
showed
their
excitation
essential
maintaining
physical
novel
conspecifics.
Activation
alleviated
deficits
induced
by
chronic
defeat
stress,
suggesting
therapeutic
potential.
Conversely,
overexpression
human
NPBWR1
reduced
activity
and
impaired
unfamiliar
This
effect
was
absent
polymorphic
variant
gene
(404A>T).
These
findings
highlight
how
promote
novelty
seeking
reveal
complex
interplay
between
genetic
variations
behavior.
