How our understanding of memory replay evolves

Journal of Neurophysiology, Год журнала: 2023, Номер 129(3), С. 552 - 580

Опубликована: Фев. 8, 2023

Memory reactivations and replay, widely reported in the hippocampus cortex across species, have been implicated memory consolidation, planning, spatial skill learning. Technological advances electrophysiology, calcium imaging, human neuroimaging techniques enabled neuroscientists to measure large-scale neural activity with increasing spatiotemporal resolution provided opportunities for developing robust analytic methods identify replay. In this article, we first review a large body of historically important representative replay studies from animal literature. We then discuss our current understanding functions learning, consolidation further progress computational modeling that has contributed these improvements. Next, past present analyses their limitations challenges. Finally, looking ahead, some promising detecting nonstereotypical, behaviorally nondecodable structures recordings. argue seamless integration multisite recordings, real-time decoding, closed-loop manipulation experiments will be essential delineating role wide range cognitive motor functions.

Язык: Английский

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Volitional activation of remote place representations with a hippocampal brain–machine interface

Science, Год журнала: 2023, Номер 382(6670), С. 566 - 573

Опубликована: Ноя. 2, 2023

The hippocampus is critical for recollecting and imagining experiences. This believed to involve voluntarily drawing from hippocampal memory representations of people, events, places, including maplike familiar environments. However, whether in such "cognitive maps" can be volitionally accessed unknown. We developed a brain-machine interface test rats do so by controlling their activity flexible, goal-directed, model-based manner. found that efficiently navigate or direct objects arbitrary goal locations within virtual reality arena solely activating sustaining appropriate remote places. provides insight into the mechanisms underlying episodic recall, mental simulation planning, imagination opens up possibilities high-level neural prosthetics use representations.

Язык: Английский

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A robot-rodent interaction arena with adjustable spatial complexity for ethologically relevant behavioral studies

Cell Reports, Год журнала: 2024, Номер 43(2), С. 113671 - 113671

Опубликована: Янв. 26, 2024

Outside of the laboratory, animals behave in spaces where they can transition between open areas and coverage as interact with others. Replicating these conditions laboratory be difficult to control record. This has led a dominance relatively simple, static behavioral paradigms that reduce ethological relevance behaviors may alter engagement cognitive processes such planning decision-making. Therefore, we developed method for controllable, repeatable interactions others reconfigurable space. Mice navigate large honeycomb lattice adjustable obstacles an autonomous robot coupled their actions. We illustrate system using pseudo-predator, delivering airpuffs mice. The combination mobile threat elicits diverse set behaviors, increased path diversity, peeking, baiting, providing explore ethologically relevant laboratory.

Язык: Английский

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Replay-triggered brain-wide activation in humans

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 21, 2024

The consolidation of discrete experiences into a coherent narrative shapes the cognitive map, providing structured mental representations our experiences. In this process, past memories are reactivated and replayed in sequence, fostering hippocampal-cortical dialogue. However, brain-wide engagement coinciding with sequential reactivation (or replay) remains largely unexplored. study, employing simultaneous EEG-fMRI, we capture both spatial temporal dynamics memory replay. We find that during simulation, fast sequences as detected via EEG. These transient replay events associated heightened fMRI activity hippocampus medial prefrontal cortex. Replay occurrence strengthens functional connectivity between default mode network, set brain regions key to representing map. On other hand, when subjects at rest following learning, task-related items is stronger than pre-learning rest, also hippocampal activation augmented entorhinal Together, findings highlight distributed, its This study uses EEG-fMRI investigate how replays experiences, revealing by EEG correspond increased enhanced network fMRI.

Язык: Английский

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The mosaic structure of the mammalian cognitive map

Learning & Behavior, Год журнала: 2024, Номер 52(1), С. 19 - 34

Опубликована: Янв. 17, 2024

Abstract The cognitive map, proposed by Tolman in the 1940s, is a hypothetical internal representation of space constructed brain to enable an animal undertake flexible spatial behaviors such as navigation. subsequent discovery place cells hippocampus rats suggested that map-like does exist, and also provided tool with which explore its properties. Single-neuron studies rodents conducted small singular spaces have map founded on metric framework, preserving distances directions abstract representational format. An open question whether this structure pertains over extended, often complexly structured real-world space. data reviewed here suggest not case. emerging picture instead being single, unified construct, mosaic fragments are heterogeneous, variably metric, multiply scaled, sometimes laid top each other. Important organizing factors within between include boundaries, context, compass direction, gravity. functions provide comprehensive precise rendering environment but rather support adaptive behavior, tailored species situation.

Язык: Английский

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A recurrent network model of planning explains hippocampal replay and human behavior

Nature Neuroscience, Год журнала: 2024, Номер 27(7), С. 1340 - 1348

Опубликована: Июнь 7, 2024

When faced with a novel situation, people often spend substantial periods of time contemplating possible futures. For such planning to be rational, the benefits behavior must compensate for spent thinking. Here, we capture these features by developing neural network model where itself is controlled prefrontal cortex. This consists meta-reinforcement learning agent augmented ability plan sampling imagined action sequences from its own policy, which call 'rollouts'. In spatial navigation task, learns when it beneficial, provides normative explanation empirical variability in human thinking times. Additionally, patterns policy rollouts used artificial closely resemble rodent hippocampal replays. Our work theory how brain could implement through prefrontal-hippocampal interactions, replays are triggered by-and adaptively affect-prefrontal dynamics.

Язык: Английский

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On the Varieties of Conscious Experiences: Altered Beliefs Under Psychedelics (ALBUS)

Опубликована: Ноя. 30, 2020

How is it that psychedelics so profoundly impact brain and mind? According to the model of "Relaxed Beliefs Under Psychedelics" (REBUS), 5-HT2a agonism thought help relax prior expectations, thus making room for new perspectives patterns. Here we introduce an alternative (but largely compatible) perspective proposing REBUS effects may primarily correspond a particular potentially pivotal) regime very high levels receptor agonism. Depending on both variety contextual factors specific neural systems being considered, suggest opposite also occur in which synchronous activity becomes more powerful, with accompanying "Strengthened (SEBUS) effects. Such SEBUS are consistent enhanced meaning-making observed psychedelic therapy (e.g. psychological insight noetic quality mystical experiences), imposition expectations perception (e.g., hallucinations pareidolia), delusional thinking sometimes occurs apophenia, paranoia, engendering inaccurate interpretations events, false memories). With "Altered Psychedelics” (ALBUS), propose manifestation vs. vary across dose-response curve signaling. While explore diverse range complex ideas, our basic idea fundamentally simple: experiences can be understood as kinds waking dream states varying degrees lucidity, similar underlying mechanisms. We further demonstrate utility ALBUS by providing neurophenomenological models focusing mechanisms conscious perceptual synthesis, dreaming, well episodic memory mental simulation.

Язык: Английский

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Enhanced Reactivation of Remapping Place Cells during Aversive Learning

Journal of Neuroscience, Год журнала: 2023, Номер 43(12), С. 2153 - 2167

Опубликована: Янв. 3, 2023

Study of the hippocampal place cell system has greatly enhanced our understanding memory encoding for distinct places, but how episodic memories experiences occurring within familiar environments are encoded is less clear. We developed a spatial decision-making task in which male rats learned to navigate multiarm maze goal location food reward while avoiding arms aversive stimuli were delivered. Task learning induced partial remapping CA1 cells, allowing us identify both and stable populations. Remapping cells recruited into sharp-wave ripples associated replay events greater extent than despite having similar firing rates during navigation maze. Our results suggest that recruitment may be mechanism incorporate new contextual information previously formed stabilized representation.SIGNIFICANCE STATEMENT Hippocampal provide map space animals use navigate. This can change reflect changes physical properties environment animal finds itself, also response nonphysical changes, such as valence specific locations environment. show here their tuning after context preferentially ripple-associated compared with nonremapping cells. Thus, data lend strong support hypothesis storage maps.

Язык: Английский

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A unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 1, 2023

Behavioral neuroscience faces two conflicting demands: long-duration recordings from large neural populations and unimpeded animal behavior. To meet this challenge, we developed ONIX, an open-source data acquisition system with high throughput (2GB/sec) low closed-loop latencies (<1ms) that uses a novel 0.3 mm thin tether to minimize behavioral impact. Head position rotation are tracked in 3D used drive active commutation without torque measurements. ONIX can acquire combinations of passive electrodes, Neuropixels probes, head-mounted microscopes, cameras, 3D-trackers, other sources. We perform uninterrupted, long (~7 hours) mice as they traversed complex 3-dimensional terrain. allowed exploration similar mobility non-implanted animals, contrast conventional tethered systems which restricted movement. By combining full mobility, our technology will enable new progress on questions require high-quality during ethologically grounded behaviors.

Язык: Английский

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The role of experience in prioritizing hippocampal replay

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Дек. 9, 2023

Abstract During sleep, recent memories are replayed by the hippocampus, leading to their consolidation, with a higher priority given salient experiences. To examine role of replay in selective strengthening memories, we recorded large ensembles hippocampal place cells while male rats ran repeated spatial trajectories on two linear tracks, differing either familiarity or number laps run. We observed that during rate events for track increased proportionally run animal. In contrast, sleep decreased if animal was more familiar track. Furthermore, find cumulative awake occurring behavior, influenced both novelty and duration an experience, predicts which prioritized replay, providing parsimonious neural correlate memories.

Язык: Английский

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