Frontiers in Neural Circuits,
Год журнала:
2023,
Номер
17
Опубликована: Март 3, 2023
Predictive
coding
is
a
computational
theory
on
describing
how
the
brain
perceives
and
acts,
which
has
been
widely
adopted
in
sensory
processing
motor
control.
Nociceptive
pain
involves
large
distributed
network
of
circuits.
However,
it
still
unknown
whether
this
completely
decentralized
or
requires
networkwide
coordination.
Multiple
lines
evidence
from
human
animal
studies
have
suggested
that
cingulate
cortex
insula
(cingulate-insula
network)
are
two
major
hubs
mediating
information
afferents
spinothalamic
inputs,
whereas
subregions
cortices
distinct
projections
functional
roles.
In
mini-review,
we
propose
an
updated
hierarchical
predictive
framework
for
perception
discuss
its
related
computational,
algorithmic,
implementation
issues.
We
suggest
active
inference
as
generalized
algorithm,
hierarchically
organized
traveling
waves
independent
neural
oscillations
plausible
mechanism
to
integrate
bottom-up
top-down
across
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(6), С. 5736 - 5736
Опубликована: Март 17, 2023
The
transition
from
normal
to
chronic
pain
is
believed
involve
alterations
in
several
brain
areas
that
participate
the
perception
of
pain.
These
plastic
changes
are
then
responsible
for
aberrant
and
comorbidities.
insular
cortex
consistently
found
activated
studies
patients.
Functional
insula
contribute
pain;
however,
complex
mechanisms
by
which
involved
under
pathological
conditions
still
not
clear.
In
this
review,
an
overview
function
provided
findings
on
its
role
human
summarized.
Recent
progress
preclinical
experimental
models
reviewed,
connectivity
with
other
regions
examined
shed
new
light
neuronal
cortex’s
contribution
sensation.
This
review
underlines
need
further
underlying
involvement
chronicity
expression
comorbid
disorders.
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(8), С. 3194 - 3206
Опубликована: Авг. 1, 2023
Social
behaviors,
how
individuals
act
cooperatively
and
competitively
with
conspecifics,
are
widely
seen
across
species.
Rodents
display
various
social
many
different
behavioral
paradigms
have
been
used
for
investigating
their
neural
circuit
bases.
behavior
is
highly
vulnerable
to
brain
network
dysfunction
caused
by
neurological
neuropsychiatric
conditions
such
as
autism
spectrum
disorders
(ASDs).
Studying
mouse
models
of
ASD
provides
a
promising
avenue
toward
elucidating
mechanisms
abnormal
potential
therapeutic
targets
treatment.
In
this
review,
we
outline
recent
progress
key
findings
on
underlying
behavior,
particular
emphasis
rodent
studies
that
monitor
manipulate
the
activity
specific
circuits
using
modern
systems
neuroscience
approaches.
mediated
distributed
brain-wide
among
major
cortical
(e.g.,
medial
prefrontal
cortex
(mPFC),
anterior
cingulate
cortex,
insular
(IC))
subcortical
nucleus
accumbens,
basolateral
amygdala
(BLA),
ventral
tegmental
area)
structures,
influenced
multiple
neuromodulatory
oxytocin,
dopamine,
serotonin).
We
particularly
draw
special
attention
IC
unique
area
mediates
multisensory
integration,
encoding
ongoing
interaction,
decision-making,
emotion,
empathy.
Additionally,
synthesis
demonstrates
dysfunctions
in
mPFC-BLA
circuitry
neuromodulation
prominent.
Pharmacological
rescues
local
or
systemic
oral)
administration
drugs
provided
valuable
clues
developing
new
agents
ASD.
Future
efforts
technological
advances
will
push
forward
next
frontiers
field,
elucidation
inter-brain
dynamics
during
real
virtual
interactions,
establishment
circuit-based
therapy
affecting
functions.
NeuroImage,
Год журнала:
2025,
Номер
unknown, С. 121017 - 121017
Опубликована: Янв. 1, 2025
Left-right
asymmetry
of
the
human
brain
is
widespread
through
its
anatomy
and
function.
However,
limited
microscopic
understanding
it
exists,
particularly
for
anatomical
where
there
are
few
well-established
animal
models.
In
humans,
most
regions
show
subtle,
population-average
regional
asymmetries
in
thickness
or
surface
area,
alongside
a
macro-scale
twisting
called
cerebral
petalia
which
right
hemisphere
protrudes
anteriorly
past
left.
Here,
we
ask
whether
neuroanatomical
can
be
observed
mice,
leveraging
6
mouse
neuroimaging
cohorts
from
5
different
research
groups
(∼3,500
animals).
We
found
an
anterior-posterior
pattern
volume
with
anterior
larger
on
posterior
This
appears
driven
by
similar
trends
area
positional
asymmetries,
results
together
indicating
small
brain-wide
pattern,
to
petalia.
Furthermore,
no
apparent
relationship
known
functional
emphasizing
complexity
structure-function
asymmetry.
Our
recapitulate
extend
previous
patterns
two
published
studies
as
well
capture
well-established,
bilateral
male-female
differences
positive
control.
By
establishing
signature
aim
provide
foundation
future
probe
mechanistic
underpinnings
seen
humans
-
feature
extremely
understanding.
Neuron,
Год журнала:
2024,
Номер
112(9), С. 1498 - 1517.e8
Опубликована: Март 1, 2024
Recognizing
the
affective
states
of
social
counterparts
and
responding
appropriately
fosters
successful
interactions.
However,
little
is
known
about
how
are
expressed
perceived
they
influence
decisions.
Here,
we
show
that
male
female
mice
emit
distinct
olfactory
cues
after
experiencing
distress.
These
activate
neural
circuits
in
piriform
cortex
(PiC)
evoke
sexually
dimorphic
empathic
behaviors
observers.
Specifically,
PiC
→
PrL
pathway
activated
observers,
inducing
a
preference
for
distressed
counterpart.
Conversely,
MeA
evoking
excessive
self-grooming
behaviors.
pathways
originate
from
non-overlapping
neuron
populations
with
gene
expression
signatures
regulated
by
transcription
factors
sex
hormones.
Our
study
unveils
internal
processed
through
mechanisms
at
molecular,
cellular,
circuit
levels
offers
insights
into
underpinning
differences
higher
brain
functions.
