Reward-based option competition in human dorsal stream and transition from stochastic exploration to exploitation in continuous space

Science Advances, Год журнала: 2024, Номер 10(8)

Опубликована: Фев. 23, 2024

Primates exploring and exploiting a continuous sensorimotor space rely on dynamic maps in the dorsal stream. Two complementary perspectives exist how these encode rewards. Reinforcement learning models integrate rewards incrementally over time, efficiently resolving exploration/exploitation dilemma. Working memory buffer explain rapid plasticity of parietal but lack plausible policy. The reinforcement model presented here unifies both accounts, enabling rapid, information-compressing map updates efficient transition from exploration to exploitation. As predicted by our model, activity human frontoparietal stream regions, not MT+, tracks number competing options, as preferred options are selectively maintained map, while spatiotemporally distant alternatives compressed out. When valuable new uncovered, posterior β 1 /α oscillations desynchronize within 0.4 0.7 s, consistent with option encoding -stabilized subpopulations. Together, outcomes matching locally cached reward representations rapidly update maps, biasing choices toward often-sampled, rewarded options.

Язык: Английский

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Differential stability of task variable representations in retrosplenial cortex

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 11, 2024

Abstract Cortical neurons store information across different timescales, from seconds to years. Although stability is variable regions, it can vary within a region as well. Association areas are known multiplex behaviorally relevant variables, but the of their representations not well understood. Here, we longitudinally recorded activity neuronal populations in mouse retrosplenial cortex (RSC) during performance context-choice association task. We found that exhibits levels days. Using linear classifiers, quantified three task-relevant variables. find RSC context and trial outcome display higher than motor choice, both at single cell population levels. Together, our findings show an important characteristic areas, where diverse streams stored with varying stability, which may balance representational reliability flexibility according behavioral demands.

Язык: Английский

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Behavioral strategy shapes activation of the Vip-Sst disinhibitory circuit in visual cortex

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Апрель 29, 2023

Abstract In complex environments, animals can adopt diverse strategies to find rewards. How distinct differentially engage brain circuits is not well understood. Here we investigate this question, focusing on the cortical Vip-Sst disinhibitory circuit. We characterize behavioral used by mice during a visual change detection task. Using dynamic logistic regression model individual use mixtures of comparison strategy and statistical timing strategy. Separately, also have periods task engagement disengagement. Two-photon calcium imaging shows large dependent differences in neural activity excitatory, Sst inhibitory, Vip inhibitory cells response both image changes omissions. contrast, has limited effects population activity. diversity correlates be understood parsimoniously as increased activation circuit which facilitates appropriate responses.

Язык: Английский

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New information triggers prospective codes to adapt for flexible navigation

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 1, 2023

ABSTRACT Navigating a dynamic world requires rapidly updating choices by integrating past experiences with new information. In hippocampus and prefrontal cortex, neural activity representing future goals is theorized to support planning. However, it remains unknown how prospective goal representations incorporate new, pivotal Accordingly, we designed novel task that precisely introduces information using virtual reality, recorded as mice flexibly adapted their planned destinations. We found triggered increased hippocampal of both possible goals; while in caused shift the choice. When did not adapt, choice codes failed switch, despite relatively intact representations. Prospective code depended on commitment initial degree adaptation needed. Thus, show update adapt ongoing navigational plans.

Язык: Английский

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Locomotion-dependent auditory gating to the parietal cortex mediates flexible multisensory decisions

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 17, 2024

Abstract Decision-making in mammals is fundamentally based on the integration of several senses. When different sensory inputs guide conflicting outcomes, animals make decisions following prepotent modality. However, neural basis state-dependent flexibility dominance and multisensory remains obscure. Here, we found that locomotion switched auditory-dominant to visual-dominant ones mice with audiovisual conflicts. made decisions, visual representation posterior parietal cortex (PPC) was weakened. Prolonged restored PPC induced visually dominant by inhibiting auditory cortical neurons projecting (AC ). In contrast, it had no effect AC projection striatum, which mediated decisions. Locomotion activated AC-projecting secondary motor neurons, preferentially inhibited neurons. Our findings demonstrate flexible gating afferents association depending locomotor conditions.

Язык: Английский

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