Antagonistic circuits mediating infanticide and maternal care in female mice

Nature, Год журнала: 2023, Номер 618(7967), С. 1006 - 1016

Опубликована: Июнь 7, 2023

Язык: Английский

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Hypothalamic control of innate social behaviors

Science, Год журнала: 2023, Номер 382(6669), С. 399 - 404

Опубликована: Окт. 26, 2023

Sexual, parental, and aggressive behaviors are central to the reproductive success of individuals species survival thus supported by hardwired neural circuits. The behavior control column (RBCC), which comprises medial preoptic nucleus (MPN), ventrolateral part ventromedial hypothalamus (VMHvl), ventral premammillary (PMv), is essential for all social behaviors. RBCC integrates diverse hormonal metabolic cues adjusts an animal's physical activity, hence chance encounters. further engages mesolimbic dopamine system maintain interest reinforces actions that time-locked with We propose brainstem form a dual-control generating moment-to-moment actions. This Review summarizes recent progress regarding identities cells their pathways drive different aspects

Язык: Английский

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A dedicated hypothalamic oxytocin circuit controls aversive social learning

Nature, Год журнала: 2024, Номер unknown

Опубликована: Янв. 24, 2024

Язык: Английский

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Experience-dependent dopamine modulation of male aggression

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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Hyperexcited limbic neurons represent sexual satiety and reduce mating motivation

Science, Год журнала: 2023, Номер 379(6634), С. 820 - 825

Опубликована: Фев. 9, 2023

Transient sexual experiences can have long-lasting effects on behavioral decisions, but the neural coding that accounts for this change is unclear. We found ejaculation experience selectively activated estrogen receptor 2 (Esr2)-expressing neurons in bed nucleus of stria terminalis (BNST)-BNSTEsr2-and led to persistent decreases firing threshold days, during which time mice displayed satiety. Inhibition hyperexcited BNSTEsr2 elicited fast mating recovery satiated both sexes. In males, such hyperexcitability reduced motivation and was partially mediated by larger HCN (hyperpolarization-activated cyclic nucleotide-gated) currents. Thus, not only encode a specific action also represent state satiety, alterations neuronal ion channel contribute experience-dependent long-term changes drive.

Язык: Английский

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A hypothalamic pathway that suppresses aggression toward superior opponents

Nature Neuroscience, Год журнала: 2023, Номер 26(5), С. 774 - 787

Опубликована: Апрель 10, 2023

Язык: Английский

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Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors

Nature Neuroscience, Год журнала: 2023, Номер 26(12), С. 2131 - 2146

Опубликована: Ноя. 9, 2023

Social behaviors are innate and supported by dedicated neural circuits, but the molecular identities of these circuits how they established developmentally shaped experience remain unclear. Here we show that medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages have distinct response patterns functions in social behavior male mice. MeA expressing transcription factor Foxp2 (MeA

Язык: Английский

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A line attractor encoding a persistent internal state requires neuropeptide signaling

Cell, Год журнала: 2024, Номер 187(21), С. 5998 - 6015.e18

Опубликована: Авг. 26, 2024

Язык: Английский

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The multi-stage plasticity in the aggression circuit underlying the winner effect

Cell, Год журнала: 2024, Номер 187(24), С. 6785 - 6803.e18

Опубликована: Окт. 14, 2024

Язык: Английский

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Neurocircuits for motivation

Science, Год журнала: 2023, Номер 382(6669), С. 394 - 398

Опубликована: Окт. 26, 2023

The nervous system coordinates various motivated behaviors such as feeding, drinking, and escape to promote survival evolutionary fitness. Although the precise behavioral repertoires required for distinct are diverse, common features approach or avoidance suggest that brain substrates a wide range of behaviors. In this Review, I describe framework by which neural circuits specified some innate drives regulate activity ventral tegmental area (VTA) dopamine neurons reinforce ongoing planned actions fulfill motivational demands. This may explain why signaling from VTA is ubiquitously involved in many types diverse volitional actions, well how sensory interoceptive cues can initiate specific goal-directed actions.

Язык: Английский

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