Neurobiology of Stress,
Год журнала:
2024,
Номер
34, С. 100704 - 100704
Опубликована: Дек. 17, 2024
Inescapable
stressful
events
often
precipitate
long-term
alterations
in
emotion-related
behaviors
and
poor
sleep
quality,
with
anxiety
being
a
prevalent
associated
disorder.
The
defensive
burying
behavior
of
rodents
is
response
to
imminent
threats
that
becomes
markedly
pronounced
anxiety.
However,
the
neural
foundations
etiology
remain
largely
unknown.
In
this
study,
we
established
model
employing
object
binding
elicit
increased
mice,
thereby
enhancing
fear
resolution
subsequently
reducing
anxious
behaviors.
Notably,
mice
shock
an
exhibited
less
exploration
zona
incerta
(ZI)
neurons
showed
higher
calcium
activity
during
as
compared
Shock
only
mice.
Although
ZI
Object
was
identical
more
behavior.
Furthermore,
time
spent
center
open-field
test
directly
proportional
duration
Chemogenetic
activation
extended
concomitantly
ameliorated
anxiety-like
Importantly,
chemogenetic
enhancement
projection
from
ventral
periaqueductal
gray
(vPAG),
brain
region
plays
critical
role
autonomic
function,
normalizes
without
influencing
Collectively,
these
findings
systematically
reveal
functions
underlying
mechanisms
ZI-vPAG
circuit
controlling
akin
anxiety,
offering
significant
insights
into
ZI's
pathophysiology
disorders.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Янв. 5, 2023
The
lateral
hypothalamus
(LH)
is
physiologically
critical
in
brain
functions.
LH
also
plays
an
important
role
drug
addiction.
However,
neural
circuits
underlying
involvement
of
addiction
remain
obscure.
In
the
present
study,our
results
showed
that
male
mice,
during
context-induced
expression
morphine
withdrawal
memory,
glutamatergic
neurons
played
role;
dopamine
D1
receptor-expressing
medium
spiny
(D1-MSNs)
projecting
from
core
nucleus
accumbens
(NAcC)
to
were
upstream
circuit
activate
neurons;
D1-MSNs
NAcC
activated
through
inhibiting
local
gamma-aminobutyric
acid
(GABA)
neurons.
These
suggest
disinhibited
by
importantly
contribute
memory.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Окт. 28, 2023
Abstract
The
ventral
striatum
is
a
reward
center
implicated
in
the
pathophysiology
of
depression.
It
contains
islands
Calleja,
clusters
dopamine
D3
receptor-expressing
granule
cells,
predominantly
olfactory
tubercle
(OT).
These
OT
neurons
regulate
self-grooming,
repetitive
behavior
manifested
affective
disorders.
Here
we
show
that
chronic
restraint
stress
(CRS)
induces
robust
depression-like
behaviors
mice
and
decreases
excitability
neurons.
Ablation
or
inhibition
these
leads
to
behaviors,
whereas
their
activation
ameliorates
CRS-induced
behaviors.
Moreover,
has
rewarding
effect,
which
diminishes
when
grooming
blocked.
Finally,
propose
model
explains
how
may
influence
release
via
synaptic
connections
with
spiny
projection
(SPNs)
project
midbrain
Our
study
reveals
crucial
role
bidirectionally
mediating
suggesting
potential
therapeutic
target.
Stress
coping
involves
innate
and
active
motivational
behaviors
that
reduce
anxiety
under
stressful
situations.
However,
the
neuronal
bases
directly
linking
stress,
anxiety,
motivation
are
largely
unknown.
Here,
we
show
acute
stressors
activate
mouse
GABAergic
neurons
in
interpeduncular
nucleus
(IPN).
Stress-coping
behavior
including
self-grooming
reward
sucrose
consumption
inherently
reduced
IPN
neuron
activity.
Optogenetic
silencing
of
activation
during
stress
episodes
mimicked
strategies
alleviated
anxiety-like
behavior.
In
a
model
stress-enhanced
for
seeking,
photoinhibition
stress-induced
sucrose,
whereas
photoactivation
or
excitatory
inputs
from
medial
habenula
potentiated
seeking.
Single-cell
sequencing,
fiber
photometry,
optogenetic
experiments
revealed
stress-activated
drive
motivated
seeking
express
somatostatin.
Together,
these
data
suggest
induces
motivates
to
oppose
as
an
anxiolytic
stress-coping
mechanism.
ACS Chemical Neuroscience,
Год журнала:
2023,
Номер
14(19), С. 3588 - 3598
Опубликована: Сен. 13, 2023
Re-examining
the
relationship
between
neuropeptide
systems
and
neural
circuits
will
help
us
to
understand
more
intensively
critical
role
of
neuropeptides
in
brain
function
as
responsible
for
specific
functions
are
gradually
revealed.
Gastrin-releasing
peptide
receptors
(GRPRs)
Gαq-coupling
widely
distributed
brain,
including
hippocampus,
amygdala,
hypothalamus,
nucleus
tractus
solitarius
(NTS),
suprachiasmatic
(SCN),
paraventricular
hypothalamus
(PVN),
preoptic
area
(POA),
preBötzinger
complex
(preBötC),
etc.,
implying
GRP/GRPR
system
is
involved
modulating
multiple
functions.
In
this
review,
we
focus
on
functionality
GRPR
neurons
regulatory
memory
cognition,
fear,
depression
anxiety,
circadian
rhythms,
contagious
itch,
gastric
acid
secretion,
food
intake,
body
temperature,
sighing
behavior.
It
can
be
found
that
usually
centered
a
certain
or
anatomical
structure
modulates
richer
behaviors
by
connecting
with
additional
different
nuclei.
order
explain
mechanism
system,
precise
intervention
methods
needed.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Depression
represents
a
prevalent
and
enduring
mental
disorder
of
significant
concern
within
the
clinical
domain.
Extensive
research
indicates
that
depression
is
very
complex,
with
many
interconnected
pathways
involved.
Most
related
to
focuses
on
monoamines,
neurotrophic
factors,
hypothalamic-pituitary-adrenal
axis,
tryptophan
metabolism,
energy
mitochondrial
function,
gut-brain
glial
cell-mediated
inflammation,
myelination,
homeostasis,
brain
neural
networks.
However,
recently,
Ketamine,
an
ionotropic
N-methyl-D-aspartate
(NMDA)
receptor
antagonist,
has
been
discovered
have
rapid
antidepressant
effects
in
patients,
leading
novel
successful
treatment
approaches
for
mood
disorders.
This
review
aims
summarize
latest
findings
insights
into
various
signaling
systems
observed
patients
animal
models,
providing
more
comprehensive
view
neurobiology
anxious-depressive-like
behavior.
Specifically,
it
highlights
key
mechanisms
ketamine
as
rapid-acting
antidepressant,
aiming
enhance
neuropsychiatric
Moreover,
we
discuss
potential
prophylactic
or
therapeutic
intervention
stress-related
psychiatric
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 5, 2024
Dopaminergic
(DA)
neurons
are
known
to
play
a
key
role
in
controlling
behaviors.
While
DA
other
brain
regions
extensively
characterized,
those
zona
incerta
(ZI
