Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 21, 2024
Aging-related
memory
impairment
and
pathological
disorders
such
as
Alzheimer’s
disease
differ
between
males
females,
yet
little
is
known
about
how
aging-related
changes
in
the
transcriptome
chromatin
environment
sexes
hippocampus.
To
investigate
this
question,
we
compared
accessibility
landscape
gene
expression/alternative
splicing
pattern
of
young
adult
aged
mouse
hippocampus
both
females
using
ATAC-seq
RNA-seq.
We
detected
significant
aging-dependent
expression
genes
involved
immune
response
synaptic
function
alternative
myelin
sheath
genes.
found
sex-bias
hundreds
genes,
including
female-biased
male-biased
function.
Aging
was
associated
with
increased
male
female
hippocampus,
especially
repetitive
elements,
an
increase
LINE-1
transcription.
autosomes
X
chromosome,
enriched
at
promoters
CpG-rich
regions.
Sex
differences
were
amplified
aging,
findings
that
may
shed
light
on
sex
loss.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(18)
Опубликована: Март 27, 2024
Repairing
spinal
cord
injury
(SCI)
is
a
global
medical
challenge
lacking
effective
clinical
treatment.
Developing
human-engineered
tissues
that
can
replenish
lost
cells
and
restore
regenerative
microenvironment
offers
promising
potential
for
SCI
therapy.
However,
creating
vascularized
human
cord-like
(VSCT)
mimic
the
diverse
cell
types
longitudinal
parallel
structural
features
of
remains
significant
hurdle.
In
present
study,
VSCTs
are
engineered
using
embryonic
cord-derived
neural
endothelial
on
linear-ordered
collagen
scaffolds
(LOCS).
Studies
have
shown
astrocytes
align
along
in
VSCT,
supporting
axon
extension
from
various
neurons
myelinated
by
oligodendrocytes.
After
transplantation
into
rats,
VSCT
survives
at
sites
promotes
endogenous
regeneration
vascularization,
ultimately
reducing
scarring
enhancing
behavioral
functional
recovery.
It
suggests
pre-vascularization
beneficial
treatment
highlights
important
role
exogenous
tissue
engineering.
Diagnostics,
Год журнала:
2024,
Номер
14(11), С. 1120 - 1120
Опубликована: Май 28, 2024
Brain
and
spinal
cord
imaging
plays
a
pivotal
role
in
aiding
clinicians
with
the
diagnosis
monitoring
of
multiple
sclerosis.
Nevertheless,
significance
magnetic
resonance
MS
extends
beyond
its
clinical
utility.
Advanced
modalities
have
facilitated
vivo
detection
various
components
pathogenesis,
and,
recent
years,
MRI
biomarkers
been
utilized
to
assess
response
patients
relapsing-remitting
available
treatments.
Similarly,
indicators
neurodegeneration
demonstrate
potential
as
primary
secondary
endpoints
trials
targeting
progressive
phenotypes.
This
review
aims
provide
an
overview
latest
advancements
brain
neuroimaging
MS.
Trends in Neurosciences,
Год журнала:
2024,
Номер
47(9), С. 677 - 692
Опубликована: Авг. 10, 2024
Traumatic
brain
injury
(TBI)
is
a
complex
condition
that
can
resolve
over
time
but
all
too
often
leads
to
persistent
symptoms,
and
the
risk
of
poor
patient
outcomes
increases
with
aging.
TBI
damages
neurons
long
axons
within
white
matter
tracts
are
critical
for
communication
between
regions;
this
causes
slowed
information
processing
neuronal
circuit
dysfunction.
This
review
focuses
on
after
multifactorial
processes
underlie
damage,
potential
recovery,
progression
degeneration.
A
multiscale
perspective
across
clinical
preclinical
advances
presented
encourage
interdisciplinary
insights
from
whole-brain
neuroimaging
down
cellular
molecular
responses
axons,
myelin,
glial
cells
tissue.
Glia,
Год журнала:
2023,
Номер
71(11), С. 2573 - 2590
Опубликована: Июль 17, 2023
Abstract
Demyelination
in
the
central
nervous
system
(CNS)
is
a
hallmark
of
many
neurodegenerative
diseases
such
as
multiple
sclerosis
(MS)
and
others.
Here,
we
studied
astrocytes
during
de‐
remyelination
cuprizone
mouse
model.
To
this
end,
exploited
ribosomal
tagging
(RiboTag)
technology
that
based
on
Cre‐mediated
cell
type‐selective
HA‐tagging
ribosomes.
Analyses
were
performed
corpus
callosum
GFAP‐Cre
+/−
Rpl22
HA/wt
mice
5
weeks
after
feeding,
at
peak
demyelination,
0.5
2
withdrawal,
when
tissue
repair
initiated.
After
reactive
showed
inflammatory
signatures
with
enhanced
expression
genes
modulate
leukocyte
migration
(
Tlr2
,
Cd86
Parp14
)
they
produced
chemokine
CXCL10,
verified
by
histology.
Furthermore,
demyelination‐induced
expressed
numerous
ligands
including
Cx3cl1
Csf1
Il34
Gas6
act
homeostatic
well
activated
microglia
thus
potentially
mediate
activation
recruitment
enhancement
their
phagocytotic
activity.
During
early
remyelination,
HA‐tagged
cells
displayed
reduced
response
signatures,
indicated
shutdown
CXCL10
production,
osteopontin
(SPP1)
factors
are
relevant
for
remodeling
Timp1
),
regeneration
axonal
repair.
late
shifted
towards
resolving
inflammation
active
suppression
lymphocyte
differentiation
support
glia
differentiation.
In
conclusion,
detected
highly
dynamic
astroglial
transcriptomic
model,
which
reflects
excessive
communication
among
highlights
different
astrocyte
functions
neurodegeneration
regeneration.
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Янв. 21, 2024
Aging-related
memory
impairment
and
pathological
disorders
such
as
Alzheimer’s
disease
differ
between
males
females,
yet
little
is
known
about
how
aging-related
changes
in
the
transcriptome
chromatin
environment
sexes
hippocampus.
To
investigate
this
question,
we
compared
accessibility
landscape
gene
expression/alternative
splicing
pattern
of
young
adult
aged
mouse
hippocampus
both
females
using
ATAC-seq
RNA-seq.
We
detected
significant
aging-dependent
expression
genes
involved
immune
response
synaptic
function
alternative
myelin
sheath
genes.
found
sex-bias
hundreds
genes,
including
female-biased
male-biased
function.
Aging
was
associated
with
increased
male
female
hippocampus,
especially
repetitive
elements,
an
increase
LINE-1
transcription.
autosomes
X
chromosome,
enriched
at
promoters
CpG-rich
regions.
Sex
differences
were
amplified
aging,
findings
that
may
shed
light
on
sex
loss.
