Journal of Neurochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 11, 2024
Abstract
Depressive
disorders
are
a
common
and
debilitating
form
of
mental
illness
with
significant
impacts
on
individuals
society.
Despite
the
high
prevalence,
underlying
causes
mechanisms
depressive
still
poorly
understood.
Neurochemical
systems,
including
serotonin,
norepinephrine,
dopamine,
have
been
implicated
in
development
perpetuation
symptoms.
Current
treatments
for
depression
target
these
neuromodulator
but
there
is
need
better
understanding
their
role
order
to
develop
more
effective
treatments.
Monitoring
neurochemical
dynamics
during
symptoms
crucial
gaining
involvement
disorders.
Genetically
encoded
sensors
emerged
recently
that
offer
spatial–temporal
resolution
ability
monitor
real
time.
This
review
explores
systems
involved
discusses
applications
limitations
current
monitoring
tools
dynamics.
It
also
highlights
potential
genetically
characterizing
depression‐related
behaviors.
Furthermore,
improvements
discussed
meet
requirements
research.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
ABSTRACT
Classic
theories
propose
opponent
functions
for
striatal
dopamine
(DA)
and
serotonin
(5-hydroxytryptamine;
5HT),
with
DA
promoting
approach
5HT
patience
or
avoidance.
How
these
neuromodulators
regulate
downstream
circuits
to
achieve
such
antagonistic
effects
remains
mysterious.
Here,
we
mapped
receptor
expression
recorded
from
genetically-identified
neurons
demonstrate
that
selectively
activate
distinct
populations
of
exert
control
over
output.
Journal of Neurochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 11, 2024
Abstract
Depressive
disorders
are
a
common
and
debilitating
form
of
mental
illness
with
significant
impacts
on
individuals
society.
Despite
the
high
prevalence,
underlying
causes
mechanisms
depressive
still
poorly
understood.
Neurochemical
systems,
including
serotonin,
norepinephrine,
dopamine,
have
been
implicated
in
development
perpetuation
symptoms.
Current
treatments
for
depression
target
these
neuromodulator
but
there
is
need
better
understanding
their
role
order
to
develop
more
effective
treatments.
Monitoring
neurochemical
dynamics
during
symptoms
crucial
gaining
involvement
disorders.
Genetically
encoded
sensors
emerged
recently
that
offer
spatial–temporal
resolution
ability
monitor
real
time.
This
review
explores
systems
involved
discusses
applications
limitations
current
monitoring
tools
dynamics.
It
also
highlights
potential
genetically
characterizing
depression‐related
behaviors.
Furthermore,
improvements
discussed
meet
requirements
research.
