Linking cognitive integrity to working memory dynamics in the aging human brain

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 21, 2023

Abstract Aging is accompanied by a decline of multiple cognitive capacities, including working memory: the ability to maintain information online for flexible control behavior. Working memory involves stimulus-selective neural activity, persisting after stimulus presentation in widely distributed cortical areas. Here, we unraveled mechanisms healthy older adults and patients with mild impairment (MCI), condition associated increased risk developing dementia. We studied sample 19 diagnosed MCI 20 controls using combination model-based behavioral psychophysics, neuropsychological assessment, magnetoencephalographic (MEG) recordings brain activity. Twenty-one younger were psychophysics only. All subjects performed visuo-spatial delayed-match-to-sample task under systematic manipulation temporal delay spatial distance between successively presented test stimuli. developed computational model latent dynamics underlying behavior fit this individual In model, representations diffused over time, threshold was applied produce match/non-match decision about locations, occasional lapses produced random decisions. For participants, related parameters summary measure integrity obtained from large battery, as well MEG activity during interval task. all groups, accuracy decreased duration sample-test distance. When sample/test distances small, exhibited larger false alarm rates than adults. The effects captured which explained age-related differences terms deterioration quality representations, rather strategy (i.e., parameter). Task governing stochasticity (diffusion noise lapse rate combined) correlated overall group, but not controls. Individual rate) also interval, assessed decoding signals, corroborating their validity markers mechanisms. Our findings provide insight into mechanistic basis aging-related changes maintenance reveal link MCI.

Язык: Английский

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Rule-based modulation of a sensorimotor transformation across cortical areas

eLife, Год журнала: 2023, Номер 12

Опубликована: Дек. 28, 2023

Flexible responses to sensory stimuli based on changing rules are critical for adapting a dynamic environment. However, it remains unclear how the brain encodes and uses rule information guide behavior. Here, we made single-unit recordings while head-fixed mice performed cross-modal selection task where they switched between two rules: licking in response tactile rejecting visual stimuli, or vice versa. Along cortical sensorimotor processing stream including primary (S1) secondary (S2) somatosensory areas, medial (MM) anterolateral (ALM) motor single-neuron activity distinguished both prior stimulus. We hypothesized that neural populations these areas would show rule-dependent preparatory states, which shape subsequent This hypothesis was supported (MM ALM) by findings (1) current could be decoded from pre-stimulus population activity; (2) subspaces containing differed rules; (3) optogenetic disruption of states impaired performance. Our indicate flexible action input can occur via configuration cortex.

Язык: Английский

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Rule-based modulation of a sensorimotor transformation across cortical areas

Опубликована: Май 20, 2024

Flexible responses to sensory stimuli based on changing rules are critical for adapting a dynamic environment. However, it remains unclear how the brain encodes rule information and uses this guide behavioral stimuli. Here, we made single-unit recordings while head-fixed mice performed cross-modal selection task in which they switched between two different blocks of trials: licking response tactile applied whisker rejecting visual stimuli, or Along cortical sensorimotor processing stream including primary (S1) secondary (S2) somatosensory areas, medial (MM) anterolateral (ALM) motor single-trial activity individual neurons distinguished both prior stimulus. Variable rule-dependent identical could principle occur via appropriate configuration pre-stimulus preparatory states neural population, would shape subsequent response. We hypothesized that populations S1, S2, MM ALM show were set manner cause according current rule. This hypothesis was supported areas by findings (1) be decoded from population MM; (2) subspaces containing differed rules; (3) optogenetic disruption within impaired performance. Our indicate flexible an action input can cortex.Task reflected cortices.Neural signals depend rule.Motor tracks switches is required rule-guided behavior.

Язык: Английский

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Rule-based modulation of a sensorimotor transformation across cortical areas

eLife, Год журнала: 2024, Номер 12

Опубликована: Июнь 6, 2024

Flexible responses to sensory stimuli based on changing rules are critical for adapting a dynamic environment. However, it remains unclear how the brain encodes and uses rule information guide behavior. Here, we made single-unit recordings while head-fixed mice performed cross-modal selection task where they switched between two rules: licking in response tactile rejecting visual stimuli, or vice versa. Along cortical sensorimotor processing stream including primary (S1) secondary (S2) somatosensory areas, medial (MM) anterolateral (ALM) motor single-neuron activity distinguished both prior stimulus. We hypothesized that neural populations these areas would show rule-dependent preparatory states, which shape subsequent This hypothesis was supported (MM ALM) by findings (1) current could be decoded from pre-stimulus population activity; (2) subspaces containing differed rules; (3) optogenetic disruption of states impaired performance. Our indicate flexible action input can occur via configuration cortex.

Язык: Английский

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Rule-based modulation of a sensorimotor transformation across cortical areas

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 22, 2023

ABSTRACT Flexible responses to sensory stimuli based on changing rules are critical for adapting a dynamic environment. However, it remains unclear how the brain encodes rule information and uses this guide behavioral stimuli. Here, we made single-unit recordings while head-fixed mice performed cross-modal selection task in which they switched between two different blocks of trials: licking response tactile applied whisker rejecting visual stimuli, or Along cortical sensorimotor processing stream including primary (S1) secondary (S2) somatosensory areas, medial (MM) anterolateral (ALM) motor single-trial activity individual neurons distinguished both prior stimulus. Variable rule-dependent identical could principle occur via appropriate configuration pre-stimulus preparatory states neural population, would shape subsequent response. We hypothesized that populations S1, S2, MM ALM show were set manner cause according current rule. This hypothesis was supported areas by findings (1) be decoded from population MM; (2) subspaces containing differed rules; (3) optogenetic disruption within impaired performance. Our indicate flexible an action input can cortex. HIGHLIGHTS Task reflected cortices. Neural signals depend Motor tracks switches is required rule-guided behavior.

Язык: Английский

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Rule-based modulation of a sensorimotor transformation across cortical areas

Опубликована: Дек. 28, 2023

Flexible responses to sensory stimuli based on changing rules are critical for adapting a dynamic environment. However, it remains unclear how the brain encodes rule information and uses this guide behavioral stimuli. Here, we made single-unit recordings while head-fixed mice performed cross-modal selection task in which they switched between two different blocks of trials: licking response tactile applied whisker rejecting visual stimuli, or Along cortical sensorimotor processing stream including primary (S1) secondary (S2) somatosensory areas, medial (MM) anterolateral (ALM) motor single-trial activity individual neurons distinguished both prior stimulus. Variable rule-dependent identical could principle occur via appropriate configuration pre-stimulus preparatory states neural population, would shape subsequent response. We hypothesized that populations S1, S2, MM ALM show were set manner cause according current rule. This hypothesis was supported areas by findings (1) be decoded from population MM; (2) subspaces containing differed stimulus during stimulus-evoked response; (3) optogenetic disruption within impaired performance. Our indicate flexible an action input can cortex.Task reflected cortices.Neural signals depend rule.Motor tracks switches is required rule-guided behavior.

Язык: Английский

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