Radiation-induced
brain
injury
(RIBI)
is
a
debilitating
sequela
after
cranial
radiotherapy.
Research
on
the
topic
of
RIBI
has
gradually
entered
public
eye,
with
more
innovations
and
applications
evidence-based
research
biological
mechanism
in
field
that.
This
was
first
bibliometric
analysis
RIBI,
assessing
related
to
radiation
articles
that
were
published
during
1998–2023,
provide
an
emerging
theoretical
basis
for
future
development
RIBI.
Literature
obtained
from
Web
Science
Core
Collection
(WOSCC)
its
inception
December
31,
2023.
The
column
publications,
author
details,
affiliated
institutions
countries,
publication
year,
keywords
also
recorded.
A
total
2543
journal
selected.
annual
publications
fluctuated
within
certain
range.
Journal
Neuro-oncology
most
Radiation
Oncology
impactful
one.
LIMOLI
CL
prolific
37
shared
highest
h-index
BARNETT
GH.
top
one
country
USA
University
California
System,
respectively.
Clusters
co-keywords
demonstrated
temporal
trends
this
primarily
focused
imaging
examination
therapy
study
collects,
visualizes,
analyzes
literature
over
last
25
years
map
process,
frontiers
hotspots,
cutting-edge
directions
clinical
practice
mechanisms
Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Янв. 29, 2024
Microglia
is
the
major
contributor
of
post-stroke
neuroinflammation
cascade
and
crucial
cellular
target
for
treatment
ischemic
stroke.
Currently,
endogenous
mechanism
underlying
microglial
activation
following
stroke
remains
elusive.
Serglycin
(SRGN)
a
proteoglycan
expressed
in
immune
cells.
Up
to
now,
role
SRGN
on
largely
unexplored.
Experimental & Molecular Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
Neuroinflammation,
a
significant
contributor
to
various
neurodegenerative
diseases,
is
strongly
associated
with
the
aging
process;
however,
date,
no
efficacious
treatments
for
neuroinflammation
have
been
developed.
In
aged
mouse
brains,
number
of
infiltrating
immune
cells
increases,
and
key
transcription
factor
increased
chemokine
levels
nuclear
kappa
B
(NF-κB).
Exosomes
are
potent
therapeutics
or
drug
delivery
vehicles
materials,
including
proteins
regulatory
genes,
target
cells.
present
study,
we
evaluated
therapeutic
efficacy
exosomes
loaded
nondegradable
form
IκB
(Exo-srIκB),
which
inhibits
translocation
NF-κB
suppress
age-related
neuroinflammation.
Single-cell
RNA
sequencing
revealed
that
these
anti-inflammatory
targeted
macrophages
microglia,
reducing
expression
inflammation-related
genes.
Treatment
Exo-srIκB
also
suppressed
interactions
between
macrophages/microglia
T
in
brain.
We
demonstrated
successfully
alleviates
by
primarily
targeting
activated
partially
modulating
functions
interferon-responsive
microglia
Thus,
our
findings
highlight
as
potential
agent
treating
Journal of Neuroinflammation,
Год журнала:
2023,
Номер
20(1)
Опубликована: Окт. 4, 2023
Abstract
Microglia
are
so
versatile
that
they
not
only
provide
immune
surveillance
for
central
nervous
system,
but
participate
in
neural
circuitry
development,
brain
blood
vessels
formation,
blood–brain
barrier
architecture,
and
intriguingly,
the
regulation
of
emotions
behaviors.
have
a
profound
impact
on
neuronal
survival,
wiring
synaptic
plasticity.
As
professional
phagocytic
cells
brain,
remove
dead
cell
debris
neurotoxic
agents
via
an
elaborate
mechanism.
The
functional
profile
microglia
varies
considerately
depending
age,
gender,
disease
context
other
internal
or
external
environmental
factors.
Numerous
studies
demonstrated
pivotal
involvement
neuropsychiatric
disorders,
including
negative
affection,
social
deficit,
compulsive
behavior,
fear
memory,
pain
symptoms
associated
with
major
depression
disorder,
anxiety
autism
spectrum
disorder
schizophrenia.
In
this
review,
we
summarized
latest
discoveries
regarding
microglial
ontogeny,
subtypes
state
spectrum,
biological
functions
mechanistic
underpinnings
emotional
behavioral
disorders.
Furthermore,
highlight
potential
microglia-targeted
therapies
propose
outstanding
questions
to
be
addressed
future
research
human
microglia.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101568 - 101568
Опубликована: Фев. 11, 2025
Acute
exposure
to
high-dose
radiation
during
head
and
neck
tumors
radiotherapy
can
result
in
radiation-induced
brain
injury
(RIBI),
characterized
by
neurocognitive
deficits,
dementia,
epilepsy.
Asparagine
endopeptidase
(AEP),
a
cysteine
proteinase,
is
effective
preventing
neurodegenerative
diseases
RIBI.
However,
the
limited
permeability
of
selective
AEP
inhibitor
(AEPI)
delivery
reduces
its
effectiveness
This
study
constructed
nose-to-brain
platform
for
AEPI
encapsulating
it
liposomes
that
are
surface
modified
with
rabies
virus
glycoprotein
(RVG29),
creating
RVG29-AEPI
liposomes.
These
demonstrated
efficient
cellular
uptake
blood-brain
barrier
penetration
vitro
vivo.
effectively
shielded
DNA
from
damage
resulted
more
reactive
oxygen
species
removal
than
primary
neurons
microglial
cells.
Notably,
treatment
(10
mg/kg
AEPI)
was
highly
systemically
safe
significantly
reduced
injury.
Behavioral
tests
liposomes-treated
mice
had
less
motor
dysfunction.
Moreover,
prevented
neuronal
microglia
cell
activation
under
photon
modern
proton
irradiation.
findings
demonstrate
potential
medication
radioprotection,
indicating
viable
technique
enormous
clinical
translation.
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Background
Spinal
cord
injury
(SCI)
is
a
severe
condition
leading
to
significant
disability
and
high
mortality.
The
role
of
the
secreted
phosphoprotein
1
(SPP1)
signaling
pathway
in
SCI,
which
quickly
activated
after
injury,
critical
for
intercellular
communication
but
remains
poorly
understood.
Aims
This
study
aimed
explore
function
regulatory
mechanisms
SPP1
SCI
investigate
its
potential
as
therapeutic
target
improving
functional
recovery
injury.
Materials
Methods
Single‐cell
RNA
sequencing
(scRNA‐seq)
was
employed
identify
ligands
receptors
pathway,
particularly
microglia/macrophages.
Recombinant
(rSPP1)
used
vitro
vivo
assess
effects
on
neuronal
maturation,
mitochondrial
energy
axons,
SCI.
Pseudotime
analysis
conducted
examine
Spp1
microglial
activation
proliferation.
DNA‐pulldown
experiments
were
performed
upstream
proteins
.
Results
primarily
localized
microglia
with
rSPP1
promoting
maturation
enhancing
axons.
Injection
into
injured
spinal
resulted
improvement
recovery.
indicated
that
involved
proliferation
microglia.
Histone
H4
lysine
12
lactylation
(H4K12la)
found
promote
transcription
reprogrammed
postinjury.
Discussion
Our
findings
reveal
novel
mechanism
involving
activation,
function,
glycolytic
reprogramming.
new
insight
provides
deeper
understanding
contribution
response.
Conclusion
uncovers
previously
unreported
offering
