A general framework for characterizing optimal communication in brain networks DOI Creative Commons
Kayson Fakhar, Fatemeh Hadaeghi, Caio Seguin

и другие.

eLife, Год журнала: 2025, Номер 13

Опубликована: Март 25, 2025

Efficient communication in brain networks is foundational for cognitive function and behavior. However, how efficiency defined depends on the assumed model of signaling dynamics, e.g., shortest path signaling, random walker navigation, broadcasting, diffusive processes. Thus, a general model-agnostic framework characterizing optimal neural needed. We address this challenge by assigning through virtual multi-site lesioning regime combined with game theory, applied to large-scale models human dynamics. Our quantifies exact influence each node exerts over every other, generating maps given underlying These descriptions reveal patterns unfold if regions are set maximize their one another. Comparing these variety showed that closely resembles broadcasting which leverage multiple parallel channels information dissemination. Moreover, we found brain’s most influential its rich-club, exploiting topological vantage point across numerous pathways enhance reach even connections weak. Altogether, our work provides rigorous versatile communication, uncovers regions, features influence.

Язык: Английский

Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences DOI Open Access
Ning Wang, Yimeng Wang,

Mingkun Guo

и другие.

Опубликована: Апрель 3, 2025

The experience-dependent spatial cognitive process requires sequential organization of hippocampal neural activities by theta rhythm, which develops to represent highly compressed information for rapid learning. However, how the sequences were developed in a finer time scale within cycles remains unclear. In this study, we found that sweep-ahead structure developing with exploration was predominantly dependent on relatively large proportion FG-cells, i.e. subset place cells dominantly phase-locked fast gamma rhythms. These ensembles integrated consistently firing at precessing slow phases cycle. Accordingly, FG-cell positively correlated intensity phase precession, particular during early development sequences. findings highlight dynamic network-modulation and may further facilitate memory encoding retrieval.

Язык: Английский

Процитировано

0
The Role of the Dorsolateral Prefrontal Cortex in Ego Dissolution and Emotional Arousal During the Psychedelic State DOI Creative Commons

Clayton R. Coleman,

Kenneth Shinozuka, Robert Tromm

и другие.

Human Brain Mapping, Год журнала: 2025, Номер 46(5)

Опубликована: Апрель 1, 2025

ABSTRACT Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces profoundly altered conscious state. In conjunction with psychological support, it currently being explored as treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) brain region known to be involved in mood regulation disorders; hypofunction the left DLPFC associated This study investigated role of psycho‐emotional effects LSD functional magnetic resonance imaging (fMRI) magnetoencephalography (MEG) data healthy human participants during acute experience. fMRI data, we measured correlation between changes resting‐state connectivity (RSFC) post‐scan subjective ratings positive mood, emotional arousal, ego dissolution. We found significant, correlations dissolution & right DLPFC, thalamus, higher‐order visual area, fusiform face area (FFA). Additionally, arousal was significantly increased intraparietal sulcus (IPS), salience network (SN). A confirmational “reverse” analysis, which outputs original RSFC analysis were used input seeds, substantiated aforementioned regions both arousal. Subsequently, on directed MEG source‐localized output reverse analyses. Granger causality (GC) revealed information flow two nodes ‘ego network’, thalamus theta band, substantiating hypothesis disruptions thalamic gating underlie experience Overall, this multimodal elucidates LSD‐induced states consciousness sheds more light basis

Язык: Английский

Процитировано

0
Top-down and bottom-up interactions rely on nested brain oscillations to shape rhythmic visual attention sampling DOI Creative Commons
Jelena Trajkovic, Domenica Veniero,

Simon Hanslmayr

и другие.

PLoS Biology, Год журнала: 2025, Номер 23(4), С. e3002688 - e3002688

Опубликована: Апрель 10, 2025

Adaptive visual processing is enabled through the dynamic interplay between top-down and bottom-up (feedback/feedforward) information exchange, presumably propagated brain oscillations. Here, we causally tested for oscillatory mechanisms governing this interaction in human system. Using concurrent transcranial magnetic stimulation-electroencephalography (TMS-EEG), emulated signals by a single TMS pulse over frontal eye field (right FEF), while manipulating strength of sensory input presentation moving concentric gratings (compared to control-TMS site). FEF-TMS without led modulated occipital phase realignment, alongside higher fronto-occipital connectivity, alpha/beta band. Sensory absence increased gamma activity. Crucially, testing processes (FEF-TMS during input) revealed an nesting activity alpha/beta-band cycles. This establishes causal link phase-to-power coupling modulation feedforward signals, providing novel mechanistic insights into how attention interacts with at neural level, shaping rhythmic sampling.

Язык: Английский

Процитировано

0
Dynamic gamma modulation of hippocampal place cells predominates development of theta sequences DOI Creative Commons
Ning Wang, Yimeng Wang,

Mingkun Guo

и другие.

eLife, Год журнала: 2025, Номер 13

Опубликована: Апрель 11, 2025

The experience-dependent spatial cognitive process requires sequential organization of hippocampal neural activities by theta rhythm, which develops to represent highly compressed information for rapid learning. However, how the sequences were developed in a finer timescale within cycles remains unclear. In this study, we found rats that sweep-ahead structure developing with exploration was predominantly dependent on relatively large proportion FG-cells, is subset place cells dominantly phase-locked fast gamma rhythms. These ensembles integrated consistently firing at precessing slow phases cycle. Accordingly, FG-cell positively correlated intensity phase precession, particular during early development sequences. findings highlight dynamic network modulation and may further facilitate memory encoding retrieval.

Язык: Английский

Процитировано

0
A general framework for characterizing optimal communication in brain networks DOI Creative Commons
Kayson Fakhar, Fatemeh Hadaeghi, Caio Seguin

и другие.

eLife, Год журнала: 2025, Номер 13

Опубликована: Март 25, 2025

Efficient communication in brain networks is foundational for cognitive function and behavior. However, how efficiency defined depends on the assumed model of signaling dynamics, e.g., shortest path signaling, random walker navigation, broadcasting, diffusive processes. Thus, a general model-agnostic framework characterizing optimal neural needed. We address this challenge by assigning through virtual multi-site lesioning regime combined with game theory, applied to large-scale models human dynamics. Our quantifies exact influence each node exerts over every other, generating maps given underlying These descriptions reveal patterns unfold if regions are set maximize their one another. Comparing these variety showed that closely resembles broadcasting which leverage multiple parallel channels information dissemination. Moreover, we found brain’s most influential its rich-club, exploiting topological vantage point across numerous pathways enhance reach even connections weak. Altogether, our work provides rigorous versatile communication, uncovers regions, features influence.

Язык: Английский

Процитировано

0