L Homme, Год журнала: 2023, Номер 247-248, С. 5 - 40
Опубликована: Дек. 14, 2023
8-29).
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июль 28, 2023
Abstract The transmission of heartbeat through the cerebral vascular system is known to cause intracranial pressure pulsations. Here we describe that arterial pulsations within brain can directly modulate central neuronal activity. In a semi-intact rat preparation, elicit correlated local field oscillations in olfactory bulb (OB) are sensitive hypoxia and block mechanosensitive channels. We find mitral cell spiking activity part synchronized these oscillations. Indeed, awake animals firing subset OB neurons entrained ∼ 20 ms. Several lines evidence indicate expression ion channel membranes, most likely Piezo2, implementing pulsation transduction pathway thus baroreception OB. propose this intrinsic interoceptive mechanism modulates e.g. during arousal also could influence on wider scale.
Язык: Английский
Процитировано
2
Frontiers in Human Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Окт. 7, 2024
Neural oscillations are a prevalent phenomenon observed in various brain regions such as the cerebral cortex, hippocampus, olfactory bulb, and thalamus, playing essential roles functions like wakefulness, sensory information processing, memory, attention, emotion regulation(Hyafil et al. 2015; Hanslmayr 2019). These oscillations, reflecting coordinated regulated activity of neuronal clusters, driven by rhythmic neurons can be categorized into different types based on their response patterns to stimuli: resting-state, evoked, induced, entrained oscillations(Henao 2020). Historically, considerable research has focused neural induced external stimuli visual, auditory, signals(Deng 2024; Xu 2021). More recently, synchronization network internal signals attracted increasing attention(Engelen 2023). Interoception, or perception bodily signals, plays significant role awareness been suggested contribute emotional regulation formation self-consciousness(Tallon-Baudry 2023; Hsueh Feldman 2024).Among sources interoceptive cardiovascular system extensively studied, revealing phenomena neurovascular coupling, vasculo-neural cortical responses heartbeats. Extensive coupling established system's influence via neurotransmitters vasoactive substances(Silvani 2016; Kim 2016). However, groundbreaking findings published February 2024 have proposed novel interaction mechanism(Jammal Salameh 2024). This study demonstrated that pulsations, specifically those from cardiac cycle, directly bulb's excitability through mechanosensitive ion channels, independent traditional synaptic transmission. suggest fundamental shift understanding how blood pressure fluctuations modulate function.The working heart-brainstem preparation (WHBP), developed 1995, serves valuable platform for elucidating mechanisms governing respiratory systems integration both health disease(Paton al.2022) . Veronica Egger's group created an innovative semi-intact perfused nose-olfactory bulb-brainstem rats. model, retaining lobe brainstem, is particularly advantageous examining oscillatory lobe, other peripheral organs. Their prior studies revealed spontaneous slow field potentials could detected even absence odor molecules, rhythm interference, inputs processing cortices, piriform well transmissions limbic structures, including hippocampus(Pérez 2015) To elucidate underlying these phenomena, Luna Jammal conducted series experiments investigate causes. The researchers used peristaltic pump simulate periodic changes caused flow during By analyzing spectral characteristics mitral cell layer comparing them pulse fluctuations, they correlation between main frequencies potentials. was disrupted when pulsations were minimized, indicating potential bulb indeed vessels. Further analysis using hypoxic perfusion methods, which reduce activity, led disappearance local (LFP) supporting neurophysiological origin signals. Statistical harmonics also mediated receptors rather than further examined spatial-temporal stability oscillation finding harmonic occurred only (MCL) maintained frequency amplitude consistently across locations within MCL. robustness suggests pressure-sensitive produced MCL Piezo especially Piezo2, highly suitable tracking vascular waves due its fast activation deactivation kinetics. contribution Piezo2 confirmed pharmacological intervention computer simulation experiment. Finally, vivo corroborated bulb. study, utilizing combination preparations recordings, highlighted arterial significantly direct mechanotransductive pathway, channels. synchronized brain, mechanoreceptors, offering new perspective heart brain. As key component unit, endothelial cells sense shear stress molecular mechanisms, thereby regulating function maintaining overall hemodynamic stability(Aitken process crucial physiological tone, remodeling, inflammatory responses, function. During sensing stress, release substances affect nitric oxide (NO), ATP, prostaglandins(Bahr-Hosseini Whether indirectly regulate astrocytes achieve vasculo-neuronal communication question worth exploring. Besides cells, express channels pressure(Turovsky Studies found respond TRPV4 Piezo1 leading increase intracellular Ca2+, turn triggers glutamate, surrounding neurons(Kim Chi 2022). In contrast this importantly highlights transmitted without involvement cellular components. need input. Mechanosensitive belonging family, instrumental process. mechanical stretch converting physical electrical biochemical neurons. discovery underscores fast, intrinsic mechanism play critical processes perception, states arousal alertness. Moreover, study's offer insights dynamics. cortex's olfactory-related learning, sensitivity, associative memory animals, influenced ranges beta (15-30Hz rodents), gamma (40-100Hz theta (4-12Hz rodents) oscillations. bands rhythms, nasal inhalation flow, stimuli, highlighting complex interplay processes. conclusion, recent underscore critical, fast-responding impact illustrated Figure1. operates independently interactions, invites exploration regulation, potentially self-awareness. implications interactions extend beyond system, suggesting similar active cognitive contexts, fruitful area future research. presents several issues warrant attention. Firstly, while authors propose candidate channel mediating use non-specific blockers introduces some uncertainty regarding conclusion. Secondly, experiment results indicate 15% recorded spikes with heartbeat, proportion lower breathing. discrepancy prompts inquiries whether too subtle obscured background noise, if might integrate networks manner. Determining represent merely intriguing epiphenomenon more substantial remains challenge. Utilizing conditionally knocked-out mice may provide definitive answers questions. interoception. Interoception foundational subjective experience one's body, closely linked 2018) fact do not require input modulated forces provides body communicates internally. imply our shaping moment-to-moment self, influencing self-awareness ways. open up areas similarly continuous self-consciousness development(Park Blanke 2019) lead deeper relationship mental states, informing therapeutic strategies disorders where disrupted.
Язык: Английский
Процитировано
0
Australian Occupational Therapy Journal, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 6, 2024
Abstract Introduction Paediatric occupational therapists assess and provide intervention for children presenting with sensory processing challenges that impact their daily performance. Interoception, the ability to sense internal body signals, is an emerging practice area, yet it remains unclear how why paediatric clinicians are applying interoception related concepts in practice. Methods A scoping review was conducted report on current of published literature its application therapy comprehensive search 10 electronic databases grey conducted. Title abstract screening were completed prior full‐text evidence. The PRISMA‐ScR Checklist Crowe Critical Appraisal Tool used support a systematic process increase robust extraction appraisal data. Narrative synthesis analyse synthesise Consumer Community Involvement No consumer community involvement. Results total 18 articles included this review, including original research ( n = 8), books 4), theses/dissertations 3), opinion pieces 2), one government document. analysis identified six themes: (1) principles relevant , (2) what interoception? 3) assessment (4) clinical (5) populations receiving interoception‐based (6) relationships between other performance components . Findings indicated integrating alongside inform processes. Several assessments interventions utilised children; however, evidence strengthen use lacking. Further, there limited occupation‐based programs address deficits children. Conclusion from contribute empirical These findings informed basis by area. PLAIN LANGUAGE SUMMARY Interoception allows us feel going inside our helps notice might be feeling (e.g. if stomach grumbles, we hungry; heart beating very fast, scared; sweating, overheated). Some may present problems recognising interoceptive feelings bodies. Therefore, can help learn about own This new topic therapists, they need know more so best families. There not lot information practice, wanted already exists therapy. provides summary knowledge available summarises it. relates services found, but needed.
Язык: Английский
Процитировано
0
L Homme, Год журнала: 2023, Номер 247-248, С. 5 - 40
Опубликована: Дек. 14, 2023
8-29).
Процитировано
0