Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
The
excessive
up-regulation
of
receptor
for
advanced
glycation
end
products
(RAGE),
a
well-known
pathological
marker,
drives
the
onset
and
progression
Alzheimer's
disease.
Although
lysosome-targeting
protein
degradation
has
emerged
as
an
effective
therapeutic
modality,
limited
lysosome-sorting
efficacy
greatly
hindered
efficiency
target
proteins.
Herein,
lysosome-shuttle-like
nano-chimera
(endoTAC)
is
proposed
based
on
polyvalent
binding
mode
enhanced
RAGE
well
precise
drug
delivery.
endoTAC
shows
high
affinity
to
enhances
due
its
polyvalent-interaction
with
RAGE.
Additionally,
features
increased
accumulation
in
diseased
brain
promise
delivery
system.
After
loading
simvastatin,
SV@endoTAC
proves
successfully
reverse
both
vitro
vivo.
work
proposes
that
combination
chimera
system
can
be
promising
disease
therapy.
Human Brain Mapping,
Год журнала:
2024,
Номер
45(5)
Опубликована: Март 28, 2024
Abstract
Although
Postpartum
depression
(PPD)
and
PPD
with
anxiety
(PPD‐A)
have
been
well
characterized
as
functional
disruptions
within
or
between
multiple
brain
systems,
however,
how
to
quantitatively
delineate
system
irregularity
the
molecular
basis
of
abnormalities
in
PPD‐A
remains
unclear.
Here,
sample
entropy
(SampEn),
resting‐state
connectivity
(RSFC),
transcriptomic
neurotransmitter
density
data
were
used
investigate
irregularity,
associated
for
PPD‐A.
exhibited
higher
SampEn
medial
prefrontal
cortex
(MPFC)
posterior
cingulate
(PPC)
than
healthy
postnatal
women
(HPW)
while
showed
lower
PPC
compared
HPW
The
analysis
MPFC
seed
areas
revealed
decreased
couplings
PCC
paracentral
lobule
angular
gyrus
both
HPW.
Moreover,
abnormal
estrogenic
level
clinical
symptoms
load.
Importantly,
spatial
association
analyses
changes
transcriptome
maps
that
these
primarily
synaptic
signaling,
neuron
projection,
regulation,
amino
acid
metabolism,
cyclic
adenosine
monophosphate
(cAMP)
signaling
pathways,
neurotransmitters
5‐hydroxytryptamine
(5‐HT),
norepinephrine,
glutamate,
dopamine
so
on.
These
results
reveal
connectivities
default
mode
network
(DMN)
link
establish
first
time.
Our
findings
highlight
important
role
DMN
neuropathology
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(9), С. 3568 - 3572
Опубликована: Сен. 1, 2023
Abstract
Involvement
of
the
glutamate
system,
particularly
N-methyl-D-aspartate
(NMDA)
receptor
hypofunction,
has
long
been
postulated
to
be
part
pathophysiology
schizophrenia.
An
important
development
is
provided
by
recent
data
that
strongly
implicate
GRIN2A
,
gene
encoding
NR2A
(GluN2A)
NMDA
subunit,
in
aetiology
disorder.
Rare
variants
and
common
are
both
robustly
associated
with
genetic
risk
for
Some
rare
point
mutations
likely
affecting
channel
function,
but
most
predicted
cause
protein
truncation
thence
result,
like
variants,
reduced
expression.
We
review
genomic
evidence,
findings
from
Grin2a
mutant
mice
other
models
which
give
clues
as
phenotypic
impacts
variation.
suggest
one
consequence
dysfunction
impairment
a
form
hippocampal
synaptic
plasticity,
producing
deficits
short-term
habituation
elevated
dysregulated
levels
attention,
phenotype
relevance
schizophrenia
its
cognitive
aspects.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3733 - 3733
Опубликована: Март 27, 2024
-methyl-d-aspartate
receptors
(NMDARs)
are
the
main
class
of
ionotropic
for
excitatory
neurotransmitter
glutamate.
They
play
a
crucial
role
in
permeability
Ca
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Photobiomodulation
(PBM)
therapy
stands
as
an
innovative
neurostimulation
modality
that
has
demonstrated
both
efficacy
and
safety
in
improving
brain
function.
This
exerts
multifaceted
influences
on
neurons,
blood
vessels,
their
intricate
interplay
known
neurovascular
coupling
(NVC).
Growing
evidence
indicates
NVC
may
present
a
promising
target
for
PBM
intervention.
However,
the
detailed
mechanisms
underlying
its
therapeutic
benefits
remain
to
be
fully
understood.
review
aims
elucidate
potential
metabolic
pathways
signaling
cascades
involved
modulatory
effects
of
PBM,
while
also
exploring
extensive
repertoire
applications
neurologic
psychiatric
conditions.
The
prospects
within
realm
investigation
are
intensively
considered,
providing
deeper
insights
into
powerful
capabilities
revolutionize
treatments.
