Organization of the human cerebral cortex estimated within individuals: networks, global topography, and function

Journal of Neurophysiology, Год журнала: 2024, Номер 131(6), С. 1014 - 1082

Опубликована: Март 15, 2024

The organization of cerebral networks was estimated within individuals with intensive, repeat sampling fMRI data. A hierarchical emerged in each individual that delineated first-, second-, and third-order cortical networks. Regions distinct association consistently exhibited side-by-side juxtapositions repeated across multiple zones, clear robust functional specialization among the embedded regions.

Язык: Английский

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Dynamic computational phenotyping of human cognition

Nature Human Behaviour, Год журнала: 2024, Номер 8(5), С. 917 - 931

Опубликована: Фев. 8, 2024

Abstract Computational phenotyping has emerged as a powerful tool for characterizing individual variability across variety of cognitive domains. An individual’s computational phenotype is defined set mechanistically interpretable parameters obtained from fitting models to behavioural data. However, the interpretation these hinges critically on their psychometric properties, which are rarely studied. To identify sources governing temporal phenotype, we carried out 12-week longitudinal study using battery seven tasks that measure aspects human learning, memory, perception and decision making. examine influence state effects, each week, participants provided reports tracking mood, habits daily activities. We developed dynamic framework, allowed us tease apart time-varying effects practice internal states such affective valence arousal. Our results show many dimensions covary with factors, indicating what appears be unreliability may reflect previously unmeasured structure. These support fundamentally understanding within an individual.

Язык: Английский

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Two what, two where, visual cortical streams in humans

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 160, С. 105650 - 105650

Опубликована: Апрель 3, 2024

ROLLS, E. T. Two What, Where, Visual Cortical Streams in Humans. NEUROSCI BIOBEHAV REV 2024. Recent cortical connectivity investigations lead to new concepts about 'What' and 'Where' visual streams humans, how they connect other systems. A ventrolateral stream leads the inferior temporal cortex for object face identity, provides information hippocampal episodic memory system, anterior lobe semantic orbitofrontal emotion system. superior sulcus (STS) utilising from parietal responds moving objects faces, expression, connects social behaviour. ventromedial builds feature combinations scenes, inputs via parahippocampal scene area system that are also useful landmark-based navigation. The dorsal pathway actions space, but coordinate transforms provide self-motion update of locations scenes dark or when view is obscured.

Язык: Английский

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Specialization of the human hippocampal long axis revisited

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(3)

Опубликована: Янв. 14, 2025

The hippocampus possesses anatomical differences along its long axis. Here, we explored the functional specialization of human hippocampal axis using network-anchored precision MRI in two independent datasets (N = 11 and N 9) paired with behavioral analysis 266 238). Functional connectivity analyses demonstrated that anterior was preferentially correlated a cerebral network associated remembering, while posterior selectively contained region distinct salience. Seed regions placed within recapitulated networks. characterization task data identified replicated double dissociation. sensitive to remembering imagining future, specifically tracking process scene construction, displayed transient responses targets an oddball detection transitions between blocks. These findings suggest unexpected differential reflecting properties partner

Язык: Английский

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Human striatal association megaclusters

Journal of Neurophysiology, Год журнала: 2024, Номер 131(6), С. 1083 - 1100

Опубликована: Март 20, 2024

The striatum receives projections from multiple regions of the cerebral cortex consistent with role basal ganglia in diverse motor, affective, and cognitive functions. Within striatum, caudate association cortex, including distinct prefrontal cortex. Building on recent insights about details how juxtaposed cortical networks are specialized for aspects higher-order cognition, we revisited organization using within-individual precision neuroimaging initially two intensively scanned individuals (each 31 times). Results revealed that has side-by-side coupled to at least five distributed networks, paralleling observed We refer these spatial groupings as striatal megaclusters. Correlation maps closely seed placed within megaclusters recapitulated their spatially regions. Striatal were explored 15 additional participants 8 times), finding presence generalizes new participants. Analysis laterality further they possess asymmetries counterparts. For example, linked language network left lateralized. These results extend general notion parallel circuits discovery that, even caudate, there is fine-grained separation reflects lateralization found

Язык: Английский

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Exploring the role of dimensionality transformation in episodic memory

Trends in Cognitive Sciences, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Episodic memory must accomplish two adversarial goals: encoding and storing a multitude of experiences without exceeding the finite neuronal structure brain, recalling memories in vivid detail. Dimensionality reduction expansion ('dimensionality transformation') enable brain to meet these demands. Reduction compresses sensory input into simplified, storable codes, while reconstructs details. Although processes are essential memory, their neural mechanisms for episodic remain unclear. Drawing on recent insights from cognitive psychology, systems neuroscience, neuroanatomy, we propose accounts how dimensionality transformation occurs brain: structurally (via corticohippocampal pathways) functionally (through oscillations). By examining cross-species evidence, highlight that may support identify crucial questions future research.

Язык: Английский

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A ventromedial visual cortical ‘Where’ stream to the human hippocampus for spatial scenes revealed with magnetoencephalography

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Авг. 25, 2024

Abstract The primate including the human hippocampus implicated in episodic memory and navigation represents a spatial view, very different from place representations rodents. To understand this system humans, computations performed, pathway for view information to reach was analysed humans. Whole-brain effective connectivity measured with magnetoencephalography between 30 visual cortical regions 150 other using HCP-MMP1 atlas 21 participants while performing 0-back scene task. In ventromedial stream, V1–V4 connect ProStriate region where retrosplenial area is located. has VMV1–3 VVC. These medial parahippocampal PHA1–3, which, VMV regions, include area. have entorhinal cortex, perirhinal hippocampus. contrast, when viewing faces, more through ventrolateral stream via fusiform face cortex inferior temporal TE2p TE2a. A ‘Where’ scenes supported by diffusion topography 171 HCP at 7 T.

Язык: Английский

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Within-Individual Organization of the Human Cerebral Cortex: Networks, Global Topography, and Function

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Авг. 10, 2023

The human cerebral cortex is populated by specialized regions that are organized into networks. Here we estimated networks using a Multi-Session Hierarchical Bayesian sModel (MS-HBM) applied to intensively sampled within-individual functional MRI (fMRI) data. network estimation procedure was initially developed and tested in two participants (each scanned 31 times) then prospectively 15 new 8 11 times). Detailed analysis of the revealed global organization. Locally first-order sensory motor were surrounded spatially adjacent second-order also linked distant regions. Third-order each possessed distributed widely throughout association cortex. Moreover, distinct third-order displayed side-by-side juxtapositions with pattern repeated similarly across multiple cortical zones. We refer these as Supra-Areal Association Megaclusters (SAAMs). Within SAAM, candidate control typically three separate domain-specialized Independent task data analyzed explore response properties. somatomotor visual responded body movements stimulation, respectively. A subset transients an oddball detection task, consistent role orienting salient or novel events. networks, including within showed levels specialization. Regions working memory load stimulus domains. remaining SAAM did not track but rather dissociated language, social, spatial / episodic processing These results support model which progressively higher-order nest outwards from primary cortices. apex zones there specialization large-scale divides domain-flexible repeatedly parietal, temporal, prefrontal discuss implications findings how repeating organizational motifs may emerge during development.

Язык: Английский

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Dynamic computational phenotyping of human cognition

Опубликована: Июнь 26, 2023

Computational phenotyping has emerged as a powerful tool for characterizing individual variability across variety of cognitive domains. An individual's computational phenotype is defined set mechanistically interpretable parameters obtained from fitting models to behavioral data. However, the interpretation these hinges critically on their psychometric properties, which are rarely studied. In order identify sources governing temporal phenotype, we carried out 12-week longitudinal study using battery seven tasks that measure aspects human learning, memory, perception, and decision making. To examine influence state-like effects, each week participants provided reports tracking mood, habits daily activities. We developed dynamic framework, allowed us tease apart time-varying effects practice internal states such affective valence arousal. Our results show many dimensions covary with factors, indicating what appears be unreliability may reflect previously unmeasured structure. These support fundamentally understanding within an individual.

Язык: Английский

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Selective Brain Activations and Connectivities Related to the Storage and Recall of Human Object‐Location, Reward‐Location, and Word‐Pair Episodic Memories

Human Brain Mapping, Год журнала: 2024, Номер 45(15)

Опубликована: Окт. 15, 2024

ABSTRACT Different cortical systems to the hippocampus were activated using fMRI during different types of episodic memory task. For object with scene location memory, activations high in involved spatial processing, including ventromedial visual and medial parahippocampal system. These for system higher right hemisphere. The face processing ventrolateral stream regions FFC, PIT, V8 TE2p object‐location task than reward‐location task, also hippocampus, but selectively storage key reward (ventromedial prefrontal 10r, 10v, 10d; pregenual anterior cingulate d32, p24, p32, s32; orbitofrontal cortex reward‐related pOFC, 11l, OFC). word‐pair lower stream, language‐related Broca's area (44, 45, 47l), left hemisphere these many highly connected inferior frontal gyrus Further, effective connectivity analyses tasks showed that direction was from early V2–V4 VMV1–3 VVC processing; hippocampal system; FFC/V8/PIT temporal cortex, which has lateral TF, turn forward hippocampus.

Язык: Английский

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