A ventral hippocampal-lateral septum pathway regulates social novelty preference DOI Open Access

Maha Rashid,

Sarah Thomas, Jennifer Isaac

и другие.

Опубликована: Май 20, 2024

The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability recognize kin and engage in appropriate behaviors associated with several types dementia, including Alzheimer’s disease. Mice preferentially spend more time investigating a novel individual relative individual. Yet, how social novelty related information drives increased investigation animal remains poorly understood. Recent evidence has implicated ventral hippocampus (vHPC) as key node encoding about conspecific identity. Of particular interest are vHPC projections lateral septum (LS), region that been driving wide range motivated behaviors. this study using chemogenetics, optogenetics monosynaptic rabies tracing, we identified vHPC-LS-ventral tegmental area (VTA) pathway necessary mice investigate conspecifics. Using established LS neurons make direct connections onto dopaminergic VTA. Thus, have potential via which identity could be transformed drive

Язык: Английский

Morphine- and foot shock-responsive neuronal ensembles in the VTA possess different connectivity and biased GPCR signaling pathway DOI Creative Commons
Fan Wang,

C. Liu,

Yi Wang

и другие.

Theranostics, Год журнала: 2024, Номер 14(3), С. 1126 - 1146

Опубликована: Янв. 1, 2024

Neurons in the ventral tegmental area (VTA) are sensitive to stress and their maladaptation have been implicated psychiatric disorders such as anxiety addiction,

Язык: Английский

Процитировано

3

Early-life stress alters chromatin modifications in VTA to prime stress sensitivity DOI Open Access
Luke T. Geiger, Julie‐Anne Balouek, Lorna A. Farrelly

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 14, 2024

ABSTRACT Early-life stress increases sensitivity to subsequent stress, which has been observed among humans, other animals, at the level of cellular activity, and gene expression. However, molecular mechanisms underlying such long-lasting are poorly understood. We tested hypothesis that persistent changes in transcription transcriptional potential were maintained epigenome, through chromatin. used a combination bottom-up mass spectrometry, viral-mediated epigenome-editing, behavioral quantification, RNA-sequencing mouse model early-life focusing on ventral tegmental area (VTA), brain region critically implicated motivation, reward learning, response, mood drug disorders. find mice alters histone dynamics VTA majority these modifications associated with an open chromatin state would predict active, primed, or poised expression, including enriched histone-3 lysine-4 methylation H3K4 monomethylase Setd7. Mimicking ELS over-expression Setd7 enrichment H3K4me1 recapitulates ELS-induced hypersensitivity future stress. These findings enrich our understanding epigenetic linking environmental experiences long-term alterations reactivity within brain’s circuitry, implications for potentially treating anxiety disorders humans.

Язык: Английский

Процитировано

3

A ventral hippocampal-lateral septum pathway regulates social novelty preference DOI Open Access

Maha Rashid,

Sarah Thomas, Jennifer Isaac

и другие.

Опубликована: Май 20, 2024

The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability recognize kin and engage in appropriate behaviors associated with several types dementia, including Alzheimer’s disease. Mice preferentially spend more time investigating a novel individual relative individual. Yet, how social novelty related information drives increased investigation animal remains poorly understood. Recent evidence has implicated ventral hippocampus (vHPC) as key node encoding about conspecific identity. Of particular interest are vHPC projections lateral septum (LS), region that been driving wide range motivated behaviors. this study using chemogenetics, optogenetics monosynaptic rabies tracing, we identified vHPC-LS-ventral tegmental area (VTA) pathway necessary mice investigate conspecifics. Using established LS neurons make direct connections onto dopaminergic VTA. Thus, have potential via which identity could be transformed drive

Язык: Английский

Процитировано

3

Prospective contingency explains behavior and dopamine signals during associative learning DOI
Lechen Qian, Mark Burrell, Jay A. Hennig

и другие.

Nature Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

Процитировано

0

Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors DOI Creative Commons
Ioannis Koutlas,

Lefkothea Patrikiou,

Stef E. van der Starre

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 2, 2025

Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransmitters (NT). However, function in does not parse along NT-boundaries as, within each NT-class, certain neurons excited by reward and others stressors. Here we identify, male mice, co-activated neuronal ensembles stress, determine their role behaviors. We show that of opposite (opioid vs acute social stress) recruit two distinct ensembles. These continue be preferentially engaged congruent stimuli. Stimulation stress- or aversive/reinforcing, respectively. Strikingly, external fully require activity these small discrete conferring approach/avoidance outcomes. Overall, our study identifies positive negative coding shows indispensability behavior.

Язык: Английский

Процитировано

0

Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats DOI Creative Commons
Jaume F. Lalanza, John Chukwuma Oyem, Patty T. Huijgens

и другие.

Appetite, Год журнала: 2025, Номер unknown, С. 108146 - 108146

Опубликована: Май 1, 2025

The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, characterized by its high palatability, particularly associated with the potential excessive consumption. While prior studies indicate that junk food intake can impact circuitry, precise mechanisms underlying these effects remain elusive. Furthermore, it unclear whether functionality of this neural similarly altered other natural rewards. In study, we used fiber photometry combined a behavioral test investigate six weeks cafeteria (CAF) diet consumption on ventral tegmental area (VTA) activity responses sexual rewards female rats. Our findings demonstrate prolonged exposure CAF reduced exploration These changes were accompanied attenuated VTA. Similarly, reductions VTA observed partner, although no significant differences detected during interactions. Moreover, two-week reversal standard chow proved insufficient restore CAF-exposed animals, which continued exhibit decreased both partners. results suggest induces desensitization VTA, resulting responsiveness

Язык: Английский

Процитировано

0

Heterogeneity of mesencephalic dopaminergic neurons: From molecular classifications, electrophysiological properties to functional connectivity DOI

Xiaying Lu,

Jinhua Xue,

Yudong Lai

и другие.

The FASEB Journal, Год журнала: 2024, Номер 38(3)

Опубликована: Фев. 5, 2024

Abstract The mesencephalic dopamine (DA) system is composed of neuronal subtypes that are molecularly and functionally distinct, responsible for specific behaviors, closely associated with numerous brain disorders. Existing research has made significant advances in identifying the heterogeneity DA neurons, which necessary understanding their diverse physiological functions disease susceptibility. Moreover, there a conflict regarding electrophysiological properties distinct subsets midbrain neurons. This review aimed to elucidate recent developments including subpopulation categorization, characteristics, functional connectivity provide new strategies accurately neurons investigating underlying mechanisms these various diseases.

Язык: Английский

Процитировано

2

Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories DOI Creative Commons
Alejandro Pan-Vazquez,

Yoel Sanchez Araujo,

Brenna McMannon

и другие.

Current Biology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1

Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors DOI Creative Commons
Ioannis Koutlas,

Lefkothea Patrikiou,

Stef E. van der Starre

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 30, 2024

Abstract Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransmitters (NT). However, function in does not parse along NT-boundaries as, within each NT-class, certain neurons excited by reward and others stressors. Here we identify co-activated mouse neuronal ensembles stress, determine their role behaviors. We show that of opposite (opioid vs acute social stress) recruit two segregated intermingled small ensembles. These continue be preferentially engaged congruent stimuli. Stimulation stress- or aversive/reinforcing, respectively. Strikingly, external fully require activity these discrete conferring approach/avoidance outcomes. Overall, our study identifies distinct positive negative coding shows indispensability behavior.

Язык: Английский

Процитировано

1

Adaptive circuits for action and value information in rodent operant learning DOI Creative Commons
Alain Ríos, Kyohei Fujita, Yoshikazu Isomura

и другие.

Neuroscience Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1