Mesocorticolimbic circuit mechanisms of social dominance behavior DOI Creative Commons
Tae-Yong Choi, Se‐Jin Jeong, Ja Wook Koo

и другие.

Experimental & Molecular Medicine, Год журнала: 2024, Номер 56(9), С. 1889 - 1899

Опубликована: Сен. 2, 2024

Abstract Social animals, including rodents, primates, and humans, partake in competition for finite resources, thereby establishing social hierarchies wherein an individual’s standing influences diverse behaviors. Understanding the neurobiological underpinnings of dominance is imperative, given its ramifications health, survival, reproduction. behavior comprises several facets, recognition, decision-making, actions, indicating concerted involvement multiple brain regions orchestrating this behavior. While extensive research has been dedicated to elucidating neurobiology interaction, recent studies have increasingly delved into adverse behaviors such as hierarchy. This review focuses on latest advancements comprehending mechanisms mesocorticolimbic circuit governing dominance, with a specific focus rodent studies, intricate dynamics their implications individual well-being adaptation.

Язык: Английский

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons DOI Creative Commons
Nilüfer Sayar, Yavuz Yavuz,

Connor Laule

и другие.

Cell Reports, Год журнала: 2024, Номер 43(1), С. 113630 - 113630

Опубликована: Янв. 1, 2024

Opioids are generally known to promote hedonic food consumption. Although much of the existing evidence is primarily based on studies mesolimbic pathway, endogenous opioids and their receptors widely expressed in hypothalamic appetite circuits as well; however, role homeostatic feeding remains unclear. Using a fluorescent opioid sensor, deltaLight, here we report that mediobasal levels increase by feeding, which directly indirectly inhibits agouti-related protein (AgRP)-expressing neurons through μ-opioid receptor (MOR). AgRP-specific MOR expression increases energy surfeit contributes opioid-induced suppression appetite. Conversely, its antagonists diminish AgRP neuron activity satiety hormones. Mice with neuron-specific ablation have increased fat preference without motivation. These results suggest post-ingestion release inhibition shape choice signaling.

Язык: Английский

Процитировано

3

Morphine- and foot shock-responsive neuronal ensembles in the VTA possess different connectivity and biased GPCR signaling pathway DOI Creative Commons
Fan Wang,

C. Liu,

Yi Wang

и другие.

Theranostics, Год журнала: 2024, Номер 14(3), С. 1126 - 1146

Опубликована: Янв. 1, 2024

Neurons in the ventral tegmental area (VTA) are sensitive to stress and their maladaptation have been implicated psychiatric disorders such as anxiety addiction,

Язык: Английский

Процитировано

3

Early-life stress alters chromatin modifications in VTA to prime stress sensitivity DOI Open Access
Luke T. Geiger, Julie‐Anne Balouek, Lorna A. Farrelly

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 14, 2024

ABSTRACT Early-life stress increases sensitivity to subsequent stress, which has been observed among humans, other animals, at the level of cellular activity, and gene expression. However, molecular mechanisms underlying such long-lasting are poorly understood. We tested hypothesis that persistent changes in transcription transcriptional potential were maintained epigenome, through chromatin. used a combination bottom-up mass spectrometry, viral-mediated epigenome-editing, behavioral quantification, RNA-sequencing mouse model early-life focusing on ventral tegmental area (VTA), brain region critically implicated motivation, reward learning, response, mood drug disorders. find mice alters histone dynamics VTA majority these modifications associated with an open chromatin state would predict active, primed, or poised expression, including enriched histone-3 lysine-4 methylation H3K4 monomethylase Setd7. Mimicking ELS over-expression Setd7 enrichment H3K4me1 recapitulates ELS-induced hypersensitivity future stress. These findings enrich our understanding epigenetic linking environmental experiences long-term alterations reactivity within brain’s circuitry, implications for potentially treating anxiety disorders humans.

Язык: Английский

Процитировано

3

A ventral hippocampal-lateral septum pathway regulates social novelty preference DOI Open Access

Maha Rashid,

Sarah Thomas, Jennifer Isaac

и другие.

Опубликована: Май 20, 2024

The ability to distinguish strangers from familiar individuals is crucial for the survival of most mammalian species. In humans, an inability recognize kin and engage in appropriate behaviors associated with several types dementia, including Alzheimer’s disease. Mice preferentially spend more time investigating a novel individual relative individual. Yet, how social novelty related information drives increased investigation animal remains poorly understood. Recent evidence has implicated ventral hippocampus (vHPC) as key node encoding about conspecific identity. Of particular interest are vHPC projections lateral septum (LS), region that been driving wide range motivated behaviors. this study using chemogenetics, optogenetics monosynaptic rabies tracing, we identified vHPC-LS-ventral tegmental area (VTA) pathway necessary mice investigate conspecifics. Using established LS neurons make direct connections onto dopaminergic VTA. Thus, have potential via which identity could be transformed drive

Язык: Английский

Процитировано

3

Interconnected neural circuits mediating social reward DOI
Jennifer Isaac, Malavika Murugan

Trends in Neurosciences, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

3

Heterogeneity of mesencephalic dopaminergic neurons: From molecular classifications, electrophysiological properties to functional connectivity DOI

Xiaying Lu,

Jinhua Xue,

Yudong Lai

и другие.

The FASEB Journal, Год журнала: 2024, Номер 38(3)

Опубликована: Фев. 5, 2024

Abstract The mesencephalic dopamine (DA) system is composed of neuronal subtypes that are molecularly and functionally distinct, responsible for specific behaviors, closely associated with numerous brain disorders. Existing research has made significant advances in identifying the heterogeneity DA neurons, which necessary understanding their diverse physiological functions disease susceptibility. Moreover, there a conflict regarding electrophysiological properties distinct subsets midbrain neurons. This review aimed to elucidate recent developments including subpopulation categorization, characteristics, functional connectivity provide new strategies accurately neurons investigating underlying mechanisms these various diseases.

Язык: Английский

Процитировано

2

Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors DOI Creative Commons
Ioannis Koutlas,

Lefkothea Patrikiou,

Stef E. van der Starre

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 30, 2024

Abstract Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransmitters (NT). However, function in does not parse along NT-boundaries as, within each NT-class, certain neurons excited by reward and others stressors. Here we identify co-activated mouse neuronal ensembles stress, determine their role behaviors. We show that of opposite (opioid vs acute social stress) recruit two segregated intermingled small ensembles. These continue be preferentially engaged congruent stimuli. Stimulation stress- or aversive/reinforcing, respectively. Strikingly, external fully require activity these discrete conferring approach/avoidance outcomes. Overall, our study identifies distinct positive negative coding shows indispensability behavior.

Язык: Английский

Процитировано

1

Adaptive circuits for action and value information in rodent operant learning DOI Creative Commons
Alain Ríos, Kyohei Fujita, Yoshikazu Isomura

и другие.

Neuroscience Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

1

Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories DOI Creative Commons
Alejandro Pan-Vazquez,

Yoel Sanchez Araujo,

Brenna McMannon

и другие.

Current Biology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1

Molecular heterogeneity and development of the ventral tegmental area DOI
Catherine J. Peña, Michael DeBerardine, Kaitlin E. Sullivan

и другие.

Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 61, С. 101478 - 101478

Опубликована: Дек. 21, 2024

Язык: Английский

Процитировано

1