bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 6, 2023
Abstract
Diverse
neuron
classes
in
hippocampal
CA1
have
been
identified
through
the
heterogeneity
of
their
cellular/molecular
composition.
How
these
relate
to
function
and
network
dynamics
that
support
cognition
primates
remains
unclear.
Here
we
report
inhibitory
functional
cell
groups
freely-moving
macaques
whose
diverse
response
profiles
states
each
other
suggest
distinct
specific
roles
microcircuit
CA1.
In
addition,
pyramidal
cells
were
segregated
into
superficial
deep
layers
differed
firing
rate,
burstiness,
sharp-wave
ripple-associated
firing.
They
also
showed
strata-specific
spike-timing
interactions
with
groups,
suggestive
neural
populations.
Furthermore,
ensemble
recordings
revealed
assemblies
preferentially
organized
according
strata.
These
results
sublayer-specific
circuit
organization
may
underlie
its
role
cognition.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Фев. 20, 2024
The
study
of
brain
connectivity
has
been
a
cornerstone
in
understanding
the
complexities
neurological
and
psychiatric
disorders.
It
provided
invaluable
insights
into
functional
architecture
how
it
is
perturbed
However,
persistent
challenge
achieving
proper
spatial
resolution,
developing
computational
algorithms
to
address
biological
questions
at
multi-cellular
level,
scale
often
referred
as
mesoscale.
Historically,
neuroimaging
studies
have
predominantly
focused
on
macroscale,
providing
inter-regional
connections
but
falling
short
resolving
intricacies
neural
circuitry
cellular
or
mesoscale
level.
This
limitation
hindered
our
ability
fully
comprehend
underlying
mechanisms
disorders
develop
targeted
interventions.
In
light
this
issue,
review
manuscript
seeks
bridge
critical
gap
by
delving
domain
neuroimaging.
We
aim
provide
comprehensive
overview
conditions
affected
aberrant
connections,
image
acquisition
techniques,
feature
extraction,
data
analysis
methods
that
are
specifically
tailored
further
delineate
potential
research
elucidate
complex
questions,
with
particular
focus
schizophrenia
epilepsy.
encompasses
topics
such
dendritic
spine
quantification,
single
neuron
morphology,
region
connectivity.
showcase
applicability
significance
techniques
field
neuroscience,
highlighting
their
for
gaining
Science,
Год журнала:
2024,
Номер
385(6713), С. 1120 - 1127
Опубликована: Сен. 5, 2024
New
memories
are
integrated
into
prior
knowledge
of
the
world.
But
what
if
consecutive
exert
opposing
demands
on
host
brain
network?
We
report
that
acquiring
a
robust
(food-context)
memory
constrains
mouse
hippocampus
within
population
activity
space
highly
correlated
spike
trains
prevents
subsequent
computation
flexible
(object-location)
memory.
This
densely
firing
structure
developed
over
repeated
mnemonic
experience,
gradually
coupling
neurons
in
superficial
sublayer
CA1
stratum
pyramidale
to
whole-population
activity.
Applying
hippocampal
theta-driven
closed-loop
optogenetic
suppression
mitigate
this
neuronal
recruitment
during
formation
relaxed
topological
constraint
coactivity
and
restored
These
findings
uncover
an
organizational
principle
for
peer-to-peer
cell
meet
demands.
Cell Reports,
Год журнала:
2024,
Номер
43(8), С. 114519 - 114519
Опубликована: Июль 16, 2024
Diverse
neuron
classes
in
hippocampal
CA1
have
been
identified
through
the
heterogeneity
of
their
cellular/molecular
composition.
How
these
relate
to
function
and
network
dynamics
that
support
cognition
primates
remains
unclear.
Here,
we
report
inhibitory
functional
cell
groups
freely
moving
macaques
whose
diverse
response
profiles
states
each
other
suggest
distinct
specific
roles
microcircuit
CA1.
In
addition,
pyramidal
cells
were
grouped
by
superficial
or
deep
layer
position
differed
firing
rate,
burstiness,
sharp-wave
ripple-associated
firing.
They
also
showed
strata-specific
spike-timing
interactions
with
groups,
suggestive
segregated
neural
populations.
Furthermore,
ensemble
recordings
revealed
assemblies
preferentially
organized
according
strata.
These
results
bears
a
sublayer-specific
circuit
organization
may
shape
its
role
cognition.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Summary
Hippocampal
ripples
are
highly
synchronized
neuronal
population
patterns
reactivating
past
waking
experiences
in
the
offline
brain.
Whether
level,
structure,
and
content
of
ripple-nested
activity
consistent
across
consecutive
events
or
tuned
each
event
remains
unclear.
By
profiling
individual
using
laminar
currents
mouse
hippocampus
during
sleep/rest,
we
identified
Rad
sink
LM
featuring
current
sinks
stratum
radiatum
versus
lacunosum-moleculare
,
respectively.
These
two
ripple
profiles
recruit
neurons
differently.
integrate
recent
motifs
coactivity,
combining
superficial
deep
CA1
principal
cells
into
denser,
higher-dimensional
that
undergo
hour-long
stable
reactivation.
In
contrast,
contain
core
prior
engaging
sparser,
lower-dimensional
a
reactivation
drift,
gradually
updating
their
pre-structured
for
wakefulness.
We
propose
ripple-by-ripple
diversity
instantiates
parallel
channels
integration
wakefulness
flexible
internal
representations.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Abstract
Memory
formation
requires
neural
activity
reorganization
during
experience
that
persists
in
sleep.
How
these
processes
promote
learning
while
preserving
established
memories
remains
unclear.
We
recorded
ensemble
from
hippocampal
and
associated
regions
freely
moving
macaques
as
they
recalled
item
sequences
presented
day
(“new”),
one
prior
(“recent”),
or
over
two
weeks
(“old”).
Cell
assemblies
biased
for
old
showed
less
drift,
greater
network
connectivity,
stronger
sleep
reactivation
than
new-biased
assemblies.
Pairs
of
recent
formed
persistent
task-to-sleep
coupling
(“metassemblies”),
unlike
new
assembly
pairs.
In
the
hippocampus,
propensity
superficial
deep
CA1
pyramidal
cells
to
form
integrated
increased
with
memory
age.
These
findings
reveal
rapid
organization
stabilization
primate
brain,
suggesting
potential
mechanisms
balancing
linking
durability.
Cell Reports,
Год журнала:
2025,
Номер
44(6), С. 115808 - 115808
Опубликована: Июнь 1, 2025
Understanding
how
coordinated
neural
networks
support
brain
functions
remains
a
central
goal
in
neuroscience.
The
hippocampus,
with
its
layered
architecture
and
structured
inputs
to
diverse
cell
populations,
is
tractable
model
for
dissecting
operating
microcircuits
through
the
analysis
of
electrophysiological
signatures.
We
investigated
hippocampal
network
patterns
behaving
mice
by
developing
low-dimensional
embedding
local
field
potentials
recorded
along
CA1-to-dentate
gyrus
axis.
This
revealed
layer-specific
gamma
profiles
reflecting
spatially
organized
rhythms
their
associated
principal
cell-interneuron
firing
motifs.
Moreover,
behaviors
CA1
radial
axis
distinguished
between
deep
superficial
cells,
as
well
interneurons
from
pyramidal,
radiatum,
lacunosum-moleculare
layers.
These
findings
provide
comprehensive
map
spatiotemporal
activity
underlying
functions.
Frontiers in Cellular Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Дек. 14, 2023
First
theorized
by
Hebb,
neuronal
ensembles
have
provided
a
framework
for
understanding
how
the
mammalian
brain
operates,
especially
regarding
learning
and
memory.
Neuronal
are
discrete,
sparsely
distributed
groups
of
neurons
that
become
activated
in
response
to
specific
stimulus
thought
provide
an
internal
representation
world.
Beyond
study
region-wide
or
projection-wide
activation,
offers
increased
specificity
resolution
identify
target
memories
associations.
Neuroscientists
interested
neurobiology
learning,
memory,
motivated
behavior
used
electrophysiological-,
calcium-,
protein-based
proxies
activity
preclinical
models
better
understand
learned
behaviors.
Although
these
three
approaches
may
be
pursue
same
general
goal
studying
ensembles,
technical
differences
lead
inconsistencies
output
interpretation
data.
This
mini-review
highlights
some
methodologies
studies
discusses
their
strengths
weaknesses.
